segunda-feira, 27 de outubro de 2014

Coping with water scarcity: Effectiveness of water policies aimed at reducing consumption evaluated

 


As California enters its fourth year of severe drought, Southern California water agencies have turned to new pricing structures, expanded rebate programs and implemented other means to encourage their customers to reduce consumption.

Some of those policies have greatly reduced per capita consumption, while others have produced mixed results, according to a report published in the UC Riverside School of Public Policy journal Policy Matters. The journal is published quarterly by the School of Public Policy, and provides timely research and guidance on issues that are of concern to policymakers at the local, state, and national levels.

Water policy experts Kurt Schwabe, Ken Baerenklau and Ariel Dinar reviewed some of their recent research that was presented at a UCR workshop on urban water management in June 2014. Schwabe and Baerenklau are associate professors and Dinar is professor of environmental economics and policy. The workshop highlighted efforts by Southern California water agencies to promote water conservation, relevant research findings by UC faculty, and challenges that remain to further reduce water demand.

"California is a water-scarce state and needs to have policy tools to deal with scarcity whether in drought years or otherwise," Dinar said. Water policy research in the School of Public Policy focuses on strategies that agencies and California can take to help reduce vulnerability to drought.

Water utilities throughout California are working to satisfy a 2010 state mandate to reduce per capita urban water demand 20 percent by 2020. Reducing residential water demand is an appealing response to water scarcity as approaches such as building more storage and conveyance systems have become increasingly expensive, the authors wrote in "Coping with Water Scarcity: The Effectiveness of Allocation-Based Pricing and Conservation Rebate Programs in California's Urban Sector."

"Reducing residential water demand is also attractive given it is a local solution to relieving water stress with seemingly much recent success," they wrote.

Efforts to reduce water demand by changing behavior fall into two categories: price and non-price, the researchers said. Price-based approaches focus on adjusting the price of water while non-price approaches include other demand-management strategies such as the use of water-conserving technologies and conversion of lawns to drought-tolerant landscape, often promoted with rebates, and mandatory restrictions.

"Price-based instruments for water management … have proven to be very effective when compared to non-price instruments," the researchers found.

One such instrument is the "water budget," which has been adopted by more than 25 Southern California water agencies in recent years. Water budgets typically are defined as an indoor allocation based on the number of people in the house and an outdoor allocation based on the amount of irrigable land, special needs, and local weather conditions, according to the report. The sum of the indoor and outdoor allocations is a household's water budget. Staying within that budget is deemed efficient use. Water use that exceeds a household's budget is considered inefficient, and is priced at a higher rate to encourage conservation.

"Recent empirical evidence within southern California suggests that this sort of pricing structure can be very effective for reducing residential water demand while securing the financial cash-flow of the water utility," the researchers reported.

Non-price efforts to reduce water consumption have not been as effective, however. For example, the researchers refer to a study of 13 groundwater-dependent California cities in which modest water price increases were more effective and more cost-effective than promoting technology standards to curb water consumption.

Some studies have found that rebate programs, in particular, have shown smaller-than-expected water savings, the researchers said in the report. For example, studies show that low-flow showerheads tend to result in longer showers and frontloading washing machines result in more cycles.

"This does not mean that such measures should be abandoned, but rather suggests that achieving real water savings in a cost-effective manner requires more research and partnerships between agencies and the research community to find an optimal mix between these two approaches," the researchers said.


Story Source:

The above story is based on materials provided by University of California, Riverside. The original article was written by Bettye Miller. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kurt Schwabe, Ben Baerenklau, and Ariel Dinar. Coping With Water Scarcity: The Effectiveness of Allocation-Based Pricing and Conservation Rebate Program in California’s Urban Sector.. Policy Matters, Volume 6, Issue 1, 2014 [link]

 

Introspection.

 

Snap 2014-10-27 at 23.32.12

Eu uso o Page Plus Starter Edition, um freeware desenvolvido pela Serif, para produzir as imagens como essa acima. É um excelente software, fácil de utilizar e que produz belos efeitos visuais.

Subwavelength optical fibers to diffuse light

 


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A laser beam (emitting at a wavelength of 600 nanometers) is guided into an optical microfiber.

Researchers at the Femto-ST Institute (CNRS/UFC/UTBM/ENSMM)(1), working in collaboration with colleagues from the Charles Fabry Laboratory (CNRS/Institut d'Optique Graduate School), have just discovered a new type of light diffusion in tiny optical fibers 50 times thinner than a strand of hair! This phenomenon, which varies according to the fiber's environment, could be used to develop sensors that are innovative and highly sensitive. The work is published in the journal Nature Communications on October 24, 2014.

Optical microfibres are silica fibres tapered down to a size 50 times smaller than a strand of hair, with an approximate diameter of one micrometer (a thousandth of a millimeter) or even less. To produce these tiny objects, researchers at the Charles Fabry Laboratory heated and stretched optical fibres used in telecommunications, measuring 125 micrometers in diameter. The remainder of the study was carried out at the Femto-ST Institute in Besançon. By injecting a laser beam in these silica microwires, the CNRS researchers observed a new type of Brillouin light scattering (2) for the first time, involving surface acoustic waves. This discovery was subsequently confirmed by a numerical simulation, which helped verify the physical mechanism at play. (3)

Since the diameter of the fibers is smaller than the wavelength of the light used (1.5 micrometers, in the infrared), the light is extremely confined inside. As it travels, it infinitesimally shakes the wire, displacing it by a few nanometers (one millionth of a millimetre). This distortion gives rise to an acoustic wave that travels along the fiber surface at a velocity of 3,400 meters per second, according to the results of the researchers. The wave in turn affects the propagation of the light, as part of the light radiation returns with a different wavelength in the opposite direction.

This phenomenon had never been observed previously, for it only occurs when light is confined in a subwavelength-diameter fiber. In standard optical fibers, light travels essentially in the core of the fiber (with a 10-micrometrer diameter), and consequently does not generate surface waves.

Since the waves generated by the confinement of the light travel along the surface of the microfibers, they are sensitive to environmental factors such as temperature, pressure and ambient gas. This makes it possible to design highly sensitive and compact optical sensors for industry(4). These results also help improve our knowledge of the fundamental interaction between light and sound on an infinitesimally small scale.

  1. Femto-ST: Franche-Comté électronique mécanique thermique et optique -- sciences et technologies (CNRS/Université de Franche-Comté/Université de technologie de Belfort-Montbéliard/Ecole nationale supérieure de mécanique et des microtechniques de Besançon).
  2. "Inelastic" scattering of light by acoustic waves of a medium. In other words, the properties of the medium modify the path of light waves as well as their wavelength.
  3. Waves of the same nature as the sound waves perceived by our ears, but with a much higher frequency, and therefore inaudible.
  4. As opposed to electrical sensors, optical sensors are passive sensors (that do not need electricity), and which use the properties of light.

Apresentando o wallpaper no monitor do meu PC.

 

k5a8nqw

Também coloco, de vez em quando, temas sólidos, com textura, ou editado com o Gimp. Difícil é conservar um só. É preciso ir trocando-os de quando em quando. Pode-se esconder os ícones da área de trabalho abrindo-se um menu e posicionando o mouse em “Exibir” e selecionando ou não “Mostrar ícones na área de trabalho”. é muito prático. Pelo menos no W8 ou 8.1 existe essa possibilidade.

Um bate-papo ao frigir dos ovos

 

1) Criei alguns títulos de bate-papos para intercalá-los com postagens importantes à respeito de saúde, artigos recentes sobre doenças, pesquisas, tecnologias em medicina, e por aí vai… É claro, não se pode martelar numa tecla só, senão os leitores do meu blog pensarão que só existe doenças pelo mundo afora. Além dos bate-papos, ( ao romper da aurora, ao cair da noite, ao estalar do chicote, e este último, ao frigir dos ovos) publico também imagens de cidades pelo mundo afora, e é claro, do meu querido Brasil, que ontem re-elegeu Dilma Roussef para mais um período de 4 anos.  Vamos esperar que desta vez o Brasil dê uma melhorada na cotação internacional, que anda meio combalida.

2) Para se construir uma redação, eu acredito que existem 3 elementos : Tema, Contextualidade, e Gramática. O tema é fácil, você os tem às centenas. Mas é preciso ter um certo cuidado ao escolhê-los. Contextualidade diz respeito à uma estrutura lógica e coerente do tema. E finalmente a gramática, (é preciso ficar de olho nas vírgulas, na ortografia….)…

3) A Internet é alimentada com informações, como não poderia deixar de ser, e os internautas alimentam-se das informações também, (sob a forma de pesquisas, notícias, conselhos úteis, imagens de todos os tipos às centenas de milhões,) cada um deles procurando uma forma de ficar “por dentro” das mais recentes novidades, ou até mesmo de recordar antigos assuntos, que também estão estocados nos websites.   Publicam seus comentários (que nem sempre são sensatos), mas que democráticamente seus pares aceitam, numa boa. Afinal, a Internet ou a web como queiram, é como se fosse uma imensa família.

E eu, como não sou um literato nato, aqui me despeço depois deste curtíssimo texto, espero que melhore e os alongue aos pouco, e espero também melhorar seu contexto. O que se pode fazer com uma ideia, um tema, é desenvolvê-lo o melhor possível. Aí entra experiência, uma mente tranquila, uma conta bancária com saldo positivo, etc.

Mas quem não se comunica, se trumbica. Assim dizia um famoso animador de programas de auditório na TV, o saudoso Abelardo Barbosa, (Chacrinha).  Então, coerente ou não, vamos arriscar que nossas opiniões sejam compreendidas, porque “Verba volant, scripta manent”…

José S de Melo

 

 

 

Um bate-papo ao estalar do chicote.

 


L endo um artigo sobre testes de QI em um importante website verifiquei que hoje em dia tais testes não são tão simples como eram tempos atrás.
São divididos em etapas, e os resultados identificam  desde um besta quadrado até um super-gênio.  Considerando-se os mentalmente normais, (os que tem um QI mediano,) que compreende a grande maioria, e chegando até os gênios, (mas não aqueles que sofrem de uma síndrome que os torna incrivelmente inteligentes), cheguei a conclusão que ser muito inteligente só tem sentido se essa pessoa tiver um objetivo, digamos assim, saudável em sua vida. Como por exemplo, fundar e manter uma entidade beneficiente, formar jovens com talento para atletismo ou música, algo que valha a pena fazer sendo essa pessoa muito inteligente.
Um exemplo disso são aqueles que desenvolvem softwares de muita utilidade para os internautas, os inventores em geral, mas especialmente os que inventam produtos de muita utilidade. Sendo assim, vale a pena ser inteligente. De outro modo, não tem sentido. Ser inteligente significa em primeiro lugar o ser para si próprio e depois para os seus semelhantes.
Entre as pessoas que tem um QI entre médio e alto, que compreende uns 10% da humanidade, há uma imensa diversidade de valores no que se refere as aplicações dessas inteligências.  Em primeiro lugar, uma pessoa inteligente, de qualquer nível, terá que o ser visando em primeiro lugar ele próprio. Não faz sentido se tal indivíduo descuidar de si mesmo para ostentar suas habilidades.
Um exemplo de uma falsa inteligência, notadamente entre grandes empresários :  Ao primeiro sinal de dificuldade financeira em suas empresas, repassam o preço dos seus produtos para os atacadistas, em lugar de fazer uma análise do que está causando tais problemas internos e repará-los fazendo economia, modificando estratégias , etc.   Infelizmente isso é quase uma regra geral.  Os grandes empresários deveriam se agrupar em associações de acordo com seu tipo de negócio, e convocar reuniões cada vez que houver questões econômicas negativas no país. Existe um sem-número de alternativas para cortar gastos, e assim não repassar o preço dos produtos para os retalhistas que fatalmente irá gerar inflação e desemprego.

(Qualquer semelhança com análises de grandes economistas é mera coincidência.Alegre.)

 

José S de Melo

American Cycle: Modern Gear for Biking

 

Dwell’s roundup of tech-savvy biking gear and stylish new cycles will give you more reasons to ride. In a poor paraphrase of George Orwell, two wheels good, four wheels bad.

View Slideshow

 

Double-O Light by Paul Cocksedge Studio

Double-O Light by Paul Cocksedge Studio

Any biker who’s struggled with wraparound lights, or felt like a geeky raver due to inadvertently blinking battery packs, should appreciate this elegant solution to illuminated riding. Two magnetized rings of LEDs that attach to the front or rear of your ride, the Double-O offers a simple way to stay safe at night, and even fits inside a U-Lock. The satisfying snap of the neodymium-grade magnets lets you know they're working, and temporarily makes you feel like Magneto.

Visit the Double-0 site to be notified when the Kickstarted-funded lights are available for pre-order for the general public.

Photo by Mark Cocksedge

 

Radical new motorcycle designs to be unveiled in Tokyo

 

Radical Concepts:<br /> The Yamaha FC06

Radical Concepts: The Yamaha FC06

Image Gallery (3 images)

Thursday October 23, 2003

Three radical new bike designs from Yamaha, Honda and Suzuki respectively, plus two fuel-cell bikes from Yamaha are among the gems in-store when the 37th Tokyo Motor Show kicks-off on Friday.

Suzuki's will unveil the G-STRIDER, a next-generation motorcycle concept with an unconventionally low and long design; Yamaha's line-up includes the MABRIS hybrid model designed for tandem riding; the FC06, which uses a direct methanol type fuel cell (DMFC) unit with an output of 500W on a 50cc size bike to create a fuel cell commuter; a lightweight aluminum and carbon design known as the Tricker Pro, and an entirely new type of electric vehicle (EV) called the Dolsa wind that looks more like a bicycle than a motorbike.

Honda innovations on show in Tokyo include the GRIFFON and the PS250 city commuter and Kawasaki will present the ZZR-X - a high-speed touring machine that uses shape-changing mechanisms to allow the rider to select the riding position and functionality to suit conditions.

The "37th Tokyo Motor Show - Passenger Cars and Motorcycles 2003" will be a 13-day event running from Friday, October 24 to Wednesday, November 5at the Makuhari Messe in Chiba.

The show will open to the public on Saturday, October 25.

Wasp's 3D printers produce low-cost houses made from mud

 

Wasp hopes to bring affordable housing to poverty stricken areas with its mud-extruding 3D...

Wasp hopes to bring affordable housing to poverty stricken areas with its mud-extruding 3D printer

Image Gallery (7 images)

A need to address a lack of housing for the globe's growing population has turned up some eye-catching efforts, blending creative architecture with new, sustainable technologies. And it is increasingly looking like 3D printing could have a role to play. Italian firm Wasp is the latest to explore the potential of additive manufacturing in this area, developing a super-sized 3D printer capable of producing low-cost housing made from mud.

Mud brick homes aren't new, and have a certain appeal for the environmentally conscious due to their low carbon footprint and sustainable nature. Wasp is looking to bring these benefits to a bigger stage by providing a means to quickly create shelter in developing regions where traditional forms of construction might not be possible.

The company's mud-extruding dream builder stands around 20 ft tall (6 m) and is capable of printing structures 10 ft (3 m) in height. This puts it at around the same size as the printer used by a Chinese company earlier this year to construct 10 houses in less than 24 hours.

The idea behind Wasp's approach is the housing can be built on location, using materials found on site at zero cost. The printer can reportedly be built by two people in as little as two hours and can extrude materials ranging from mud to clay and other natural fibers. The company demonstrated the printer earlier this month at Rome's Maker Faire. While not a full scale model, at 4 m (13 ft) it was able to produce smaller versions of its mud brick dwellings and serve as a proof-of-concept.

"We will print a mixture made of clay and sand," CEO Massimo Moretti said leading up to the event. "It takes weeks to print a real house, so we will print a smaller building because we only have two days. But the print, the mixture and materials have been already tested and they’re working.”

The design for these structures is inspired by the mud dauber wasp, which build their nests using mud. As it turns out, the company's name doubles as an acronym for "World's Advanced Saving Project."

While it has exhibited the potential of its approach, Wasp is yet to detail exactly when it plans to begin deploying its 3D printers.

Source: Wasp

 

About the Author

Nick was born outside of Melbourne, Australia, with a general curiosity that has drawn him to some distant (and very cold) places. Somewhere between enduring a winter in the Canadian Rockies and trekking through Chilean Patagonia, he graduated from university and pursued a career in journalism. He now writes for Gizmag, excited by tech and all forms of innovation, Melbourne's bizarre weather and curried egg sandwiches.   All articles by Nick Lavars

Ouro Preto-MG-Brazil

 

Ouro Preto ( Black Gold) is a city in the state of Minas Gerais, Brazil, a former colonial mining town located in the Serra do Espinhaço mountains and designated a World Heritage Site by UNESCO because of its outstanding Baroque architecture.

Founded at the end of the 17th century, Ouro Preto (meaning Black Gold) was originally called Vila Rica, or "rich village", the focal point of the gold rush and Brazil's golden age in the 18th century under Portuguese rule.

The city centre contains well-preserved Portuguese colonial architecture, with few signs of modern urban development. Any new constructions are required to be in keeping with the city's historical aesthetic. 18th- and 19th-century churches decorated with gold and the sculptured works of Aleijadinho make Ouro Preto a prime tourist destination.

The tremendous wealth from gold mining in the 18th century created a city which attracted the intelligentsia of Europe. Philosophy and art flourished, and evidence of a baroque revival called the "Barroco Mineiro" is illustrated in architecture as well as by sculptors such as Aleijadinho, painters such as Mestre Athayde, composers such as Lobo de Mesquita, and poets such as Tomás António Gonzaga. At that time, Vila Rica was the largest city in Brazil, with 100,000 inhabitants.

In 1789, Ouro Preto became the birthplace of the Inconfidência Mineira, a failed attempt to gain independence from Portugal. The leading figure, Tiradentes, was hanged as a threat to any future revolutionaries.

In 1876, the Escola de Minas (Mines School) was created. This school established the technological foundation for several of the mineral discoveries in Brazil.

Ouro Preto was capital of Minas Gerais from 1720 until 1897, when the needs of government outgrew this town in the valley. The state government was moved to the new, planned city of Belo Horizonte.

Ouro_preto - edit

1280px-OuroPretoView - edit

Ouro_Preto_November_2009-13 edit - B

 

Ouro_Preto_November_2009-7 edit


Ouro Preto é um município do estado de Minas Gerais, no Brasil. É famoso por sua arquitetura colonial. Localiza-se na latitude 20º23'08" sul, longitude 43º30'29" oeste e altitude média de 1 179 metros. Sua população de 70 227 habitantes, conforme o censo de 2010 (Instituto Brasileiro de Geografia e Estatística), está distribuída em 34 272 homens e 35 955 mulheres.

Foi a primeira cidade brasileira a ser declarada, pela Organização das Nações Unidas para a Educação, a Ciência e a Cultura, Patrimônio Histórico e Cultural da Humanidade, no ano de 1980.

No município, há treze distritos, cujas informações constam no Anexo:Lista de distritos de Ouro Preto: Amarantina, Antônio Pereira, Cachoeira do Campo, Engenheiro Correia, Glaura, Lavras Novas, Miguel Burnier, Santa Rita de Ouro Preto, Santo Antônio do Leite, Santo Antônio do Salto, São Bartolomeu e Rodrigo Silva, além da sede.

Finally: Missing link between vitamin D, prostate cancer

 


A University of Colorado Cancer Center study recently published in the journal Prostate offers compelling evidence that inflammation may be the link between Vitamin D and prostate cancer. Specifically, the study shows that the gene GDF-15, known to be upregulated by Vitamin D, is notably absent in samples of human prostate cancer driven by inflammation.

"When you take Vitamin D and put it on prostate cancer cells, it inhibits their growth. But it hasn't been proven as an anti-cancer agent. We wanted to understand what genes Vitamin D is turning on or off in prostate cancer to offer new targets," says James R. Lambert, PhD, investigator at the CU Cancer Center and associate research professor in the CU School of Medicine Department of Pathology.

Since demonstrating that Vitamin D upregulates the expression of GDF-15, Lambert and colleagues, including Scott Lucia, MD, wondered if this gene might be a mechanism through which Vitamin D works in prostate cancer. Initially it seemed as if the answer was no.

"We thought there might be high levels of GDF-15 in normal tissue and low levels in prostate cancer, but we found that in a large cohort of human prostate tissue samples, expression of GDF-15 did not track with either normal or cancerous prostate tissue," Lambert says.

But then the team noticed an interesting pattern: GDF-15 was uniformly low in samples of prostate tissue that contained inflammation.

"Inflammation is thought to drive many cancers including prostate, gastric and colon. Therefore, GDF-15 may be a good thing in keeping prostate tissue healthy -- it suppresses inflammation, which is a bad actor potentially driving prostate cancer," Lambert says.

The study used a sophisticated computer algorithm to analyze immunohistochemical (IHC) data, a task that in previous studies had been done somewhat subjectively by pathologists. With this new technique, Lambert, Lucia and colleagues were able to quantify the expression of the GDF-15 protein and inflammatory cells by IHC staining on slides taken from these human prostate samples.

Additionally encouraging is that the gene GDF-15 was shown to suppress inflammation by inhibiting another target, NFkB. This target, NFkB, has been the focus of many previous studies in which it has been shown to promote inflammation and contribute to tumor formation and growth; however, researchers have previously been unable to drug NFkB to decrease its tumor-promoting behavior.

"There's been a lot of work on inhibiting NFkB," says Lambert. "Now from this starting point of Vitamin D in prostate cancer, we've come a long way toward understanding how we might use GDF-15 to target NFkB, which may have implications in cancer types far beyond prostate."


Story Source:

The above story is based on materials provided by University of Colorado Denver. The original article was written by Garth Sundem. Note: Materials may be edited for content and length.


Journal Reference:

  1. James R. Lambert, Ramon J. Whitson, Kenneth A. Iczkowski, Francisco G. La Rosa, Maxwell L. Smith, R. Storey Wilson, Elizabeth E. Smith, Kathleen C. Torkko, Hamid H. Gari, M. Scott Lucia. Reduced expression of GDF-15 is associated with atrophic inflammatory lesions of the prostate. The Prostate, 2014; DOI: 10.1002/pros.22911

 

The right to privacy in a big data world: When properly understood, privacy rules essential, experts say

 

October 25, 2014

Washington University in St. Louis

In the digital age in which we live, monitoring, security breaches and hacks of sensitive data are all too common. It has been argued that privacy has no place in this big data environment and anything we put online can, and probably will, be seen by prying eyes. In a new article privacy law expert makes the case that when properly understood, privacy rules will be an essential and valuable part of our digital future.


In the digital age in which we live, monitoring, security breaches and hacks of sensitive data are all too common. It has been argued that privacy has no place in this big data environment and anything we put online can, and probably will, be seen by prying eyes.

In a new paper, a noted Washington University in St. Louis privacy law expert makes the case that when properly understood, privacy rules will be an essential and valuable part of our digital future.

"If, as a society, we are going to retain the human values on which our political, social and economic institutions have been built, we must be able to feel secure in our digital lives," said Neil M. Richards, JD, professor of law.

Richards is an internationally recognized authority on privacy and information law.

He is co-author of a new paper "Big Data and the Future for Privacy," with Jonathan H. King, a 2013 graduate of the Washington University Intellectual Property & Technology Law LLM program and an executive at CenturyLink, a global network and cloud services provider.

In the paper, Richards and King makes three basic points about the future of privacy.

"First, we need to think differently about privacy," Richards said.

"Privacy is not merely about keeping secrets, but about the rules we use to regulate information, which is, and always has been, in intermediate states between totally secret and known to all," he said. "Privacy rules are information rules, and in an information society, information rules are inevitable."

Second, the scholars suggest that privacy protections are a means to safeguard other values. They examine several such values that privacy rules should protect, including identity, equality, security and trust.

Third, mindful of the complexity of our digital society, Richards and King suggest how meaningful privacy protection can be achieved in a big data future, through a combination of traditional regulation, "soft" regulation and the development of big data ethics.

"Our claim is that the shiny future asserted as inevitable by the pro-innovation, anti-privacy rhetoric turns out to be both shallow and unappealing on closer analysis," Richards said. "We believe there is an alternative future, where we can have the benefits of data science while at the same time preserving meaningful legal and ethical protections for data subjects."


Story Source:

The above story is based on materials provided by Washington University in St. Louis. The original article was written by Neil Schoenherr. Note: Materials may be edited for content and length.


Journal Reference:

  1. Neil M. Richards, Jonathan H. King. Big Data and the Future for Privacy. SSRN Electronic Journal, 2014; DOI: 10.2139/ssrn.2512069

 

Roman-Britons had less gum disease than modern Britons

 


 

Theya Molleson, co-author of the study from the Natural History Museum said: “This study shows a major deterioration in oral health between Roman times and modern England. By underlining the probable role of smoking, especially in determining the susceptibility to progressive periodontitis in modern populations, there is a real sign that the disease can be avoided. As smoking declines in the population we should see a decline in the prevalence of the disease.”

The Roman-British population from c. 200-400 AD appears to have had far less gum disease than we have today, according to a study of skulls at the Natural History Museum led by a King's College London periodontist. The surprise findings provide further evidence that modern habits like smoking can be damaging to oral health.

Gum disease, also known as periodontitis, is the result of a chronic inflammatory response to the build-up of dental plaque. Whilst much of the population lives with mild gum disease, factors such as tobacco smoking or medical conditions like diabetes can trigger more severe chronic periodontitis, which can lead to the loss of teeth.

The study, published in the British Dental Journal, examined 303 skulls from a Romano-British burial ground in Poundbury, Dorset for evidence of dental disease. Only 5% of the skulls showed signs of moderate to severe gum disease, compared to today's population of which around 15-30% of adults have chronic progressive periodontitis.

However many of the Roman skulls, which form part of the collections in the Palaeontology department of the Natural History Museum, showed signs of infections and abscesses, and half had caries (tooth decay). The Poundbury population also showed extensive tooth wear from a young age, as would be expected from a diet rich in coarse grains and cereals at the time.

The Poundbury cemetery community, genetically similar to modern European populations, was made up of countryside dwellers as well as a Romanised urban population. This was a non-smoking population and likely to have had very low levels of diabetes mellitus, two factors that are known to greatly increase the risk of gum disease in modern populations. Among the people who survived infancy, childhood illnesses and malnutrition into adulthood, the peak age at death appears to have been in their 40s. Infectious diseases are thought to have been a common cause of death at that time.

Professor Francis Hughes from the Dental Institute at King's College London and lead author of the study said: "We were very struck by the finding that severe gum disease appeared to be much less common in the Roman British population than in modern humans, despite the fact that they did not use toothbrushes or visit dentists as we do today. Gum disease has been found in our ancestors, including in mummified remains in Egypt, and was alluded to in writings by the Babylonians, Assyrians and Sumerians as well as the early Chinese."

Theya Molleson, co-author of the study from the Natural History Museum said: "This study shows a major deterioration in oral health between Roman times and modern England. By underlining the probable role of smoking, especially in determining the susceptibility to progressive periodontitis in modern populations, there is a real sign that the disease can be avoided. As smoking declines in the population we should see a decline in the prevalence of the disease."


Story Source:

The above story is based on materials provided by King's College London. Note: Materials may be edited for content and length.


Journal Reference:

  1. T. Raitapuro-Murray, T. I. Molleson, F. J. Hughes. The prevalence of periodontal disease in a Romano-British population c. 200-400 AD. BDJ, 2014; 217 (8): 459 DOI: 10.1038/sj.bdj.2014.908

 

High-dose vitamin D not effective for helping women with repeat reproductive tract infections

 

October 24, 2014

Ohio State University Center for Clinical and Translational Science

Vitamin D appears not to be effective for treating repeat occurrences of bacterial vaginosis (BV), the most common reproductive infection among women worldwide. While earlier studies have shown a correlation between low vitamin D levels and BV, new research shows the difficult-to-treat and frequently symptom-free reproductive infection isn’t altered by high dose vitamin D supplements.


Women with the reproductive infection bacterial vaginosis (BV) do not benefit from high-dose vitamin-D supplementation, according to new research. The findings add to a body of conflicting data about a possible link between vitamin D -- a powerful immune system regulator -- and BV, which is the most common vaginal infection among women ages 15-44 around the world.

"Earlier studies observed that women with low vitamin D levels were more likely to have bacterial vaginosis, and we hypothesized that vitamin D supplementation might reduce BV," said the trial's lead author Abigail Norris Turner, PhD, an infectious disease expert at The Ohio State University Wexner Medical Center. "However, our study found that high-dose vitamin D supplementation wasn't helpful in preventing recurrence of BV."

BV is caused by an imbalance in the bacteria that normally populate the reproductive tract, and is not sexually transmitted. Initial antimicrobial treatment is usually successful, but many women go on to have repeat episodes of BV. Some women don't have symptoms, while others have symptoms that sufferers say are embarrassing and detrimental to their sexual relationships.

Beyond embarrassment, BV has much more serious health implications: in pregnant women, it can cause spontaneous abortions, and women who have BV are more susceptible to acquiring and transmitting HIV. In the United States, 21 million women are diagnosed with BV each year, and black women are almost twice as likely to have the condition as white women.

"BV is a very real health issue for millions of women, many of whom have limited access to medical care," said Turner, who was originally an HIV epidemiologist before turning her focus to women's reproductive health more generally. "Finding a low cost, simple way to help women with recurrent BV would be a major global public health win."

The Silver Lining

For the randomized, double-blinded study, published in the American Journal of Obstetrics and Gynecology, Turner enrolled 118 women with BV from a local health department sexual health clinic. At enrollment, the women had their baseline vitamin D level measured via a blood sample, and were provided with the standard, CDC-recommended 7-day antimicrobial treatment for BV.

The women were randomized into two equal-sized groups, with one group receiving 9 doses of 50,000 IU of cholecalciferol (vitamin D3), and the other group receiving a placebo. Both groups were instructed to take either the vitamin D tablets or placebo at regular intervals during the 24-week study. Study participants' BV status and vitamin D serum levels were checked at several points across the study. None of the participants, investigators nor data analysts knew which women were receiving vitamin D and which were receiving placebo.

Turner found that while women randomized to the vitamin D arm had significant increases in their serum vitamin D levels compared to women in the placebo arm -- validating their compliance with the protocol -this did not translate into a decrease in BV recurrence. Despite not finding the evidence that she was looking for, Turner said that her research yielded other important findings for future studies.

"We learned that this high-risk population knew a lot about bacterial vaginosis, and that many women have an active interest in learning more about treating it," said Turner, who was supported by a KL2 career development grant from Ohio State's Center for Clinical and Translational Science (CCTS). "This study also gave us proof that we can effectively recruit for a large-scale clinical trial at a local health clinic."

Moving beyond vitamin D

Turner and her research mentor, Rebecca Jackson, MD, emphasize that while vitamin D may not be useful for treating women with recurrent BV, the jury is still out on the vitamin's ability to prevent BV from initially developing.

"Vitamin D is critical to a healthy immune system, so there may still be a role for it from a prevention standpoint," said Jackson, a women's health expert and Director of the CCTS. "And certainly, women of all ages should make sure they are getting adequate amounts of vitamin D through diet, daily exposure to sunlight or supplementation."

Turner says that while she is able to rule out vitamin D as a solution for recurrent BV, the disappointing results have pushed her to pursue a different track.

"I think we need to go back to why people studied vitamin D as a BV risk factor initially -- and that's the immune system and immune response," said Turner. "Most women have continually fluctuating concentrations of 'good' and 'bad' bacteria in the genital tract. What immune factors lead some women to develop BV, and others to more effectively regulate the balance of bacteria in the vagina?"

Turner is in the process of developing a grant proposal to explore her hypothesis further.


Story Source:

The above story is based on materials provided by Ohio State University Center for Clinical and Translational Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Abigail Norris Turner, Patricia Carr Reese, Karen S. Fields, Julie Anderson, Melissa Ervin, John A. Davis, Raina N. Fichorova, Mysheika Williams Roberts, Mark A. Klebanoff, Rebecca D. Jackson. A blinded, randomized controlled trial of high-dose vitamin D supplementation to reduce recurrence of bacterial vaginosis. American Journal of Obstetrics and Gynecology, 2014; 211 (5): 479.e1 DOI: 10.1016/j.ajog.2014.06.023

 

Shutting off blood supply to extremity to protect heart

 

October 24, 2014

The Norwegian University of Science and Technology (NTNU)

Shutting off the blood supply to an arm or leg before cardiac surgery protects the heart during the operation, a study shows. "The heart muscle of the patients who had restricted blood flow to their arm before surgery were able to maintain the same level of energy production during the whole operation, while heart muscle from the other patients' hearts was not. This may be important because heart tissue is dependent on energy to survive, as well as to repair injuries the cells may have endured during surgery," an investigator says.


In a study just published in the International Journal of Cardiology, researchers from the K.G. Jebsen Center for Exercise in Medicine -- Cardiac Exercise Research Group (CERG) at the Norwegian University of Science and Technology (NTNU) and the Department of Cardiothoracic Surgery at the St. Olavs Hospital in Trondheim, Norway have shown that shutting off the blood supply to an arm or leg before cardiac surgery protects the heart during the operation.

The research group wanted to see how the muscle of the left chamber of the heart was affected by a technique, called RIPC (remote ischemic preconditioning), during cardiac surgery.

RIPC works by shutting off the blood supply to an arm or a leg before heart surgery. The goal is to reduce risk during cardiac surgery in the future. The technique is not new, but its effects have never before been tested directly on the left chamber of the heart.

"During heart surgery we have to stop the blood supply to the heart to be able to operate on it. After some time without fresh blood, the heart will reduce its ability to produce energy because it doesn't get oxygen. When we shut off the bloodflow to another large muscle, such as an arm or a leg, the body prepares for an upcoming challenge by mobilizing its defense system," says the first author of the study, Katrine Hordnes Slagsvold, a PhD candidate at NTNU and medical doctor at St. Olavs Hospital.

The researchers investigated cardiac tissue from 60 patients who had coronary bypass surgery at St. Olavs Hospital in Trondheim. The patients were randomized to either undergo RIPC, or to a control group. Patients who were treated with RIPC underwent brief periods without blood supply to the arm before surgery, by inflating a blood pressure cuff for five minutes three times.

"The heart muscle of the patients who had restricted blood flow to their arm before surgery were able to maintain the same level of energy production during the whole operation, while heart muscle from the other patients' hearts was not. This may be important because heart tissue is dependent on energy to survive, as well as to repair injuries the cells may have endured during surgery," Slagsvold says.

The researchers also found that a protein called Akt was activated after RIPC, and believe that activation of this protein may be key in inducing the protective effect on the heart.


Story Source:

The above story is based on materials provided by The Norwegian University of Science and Technology (NTNU). Note: Materials may be edited for content and length.


Journal Reference:

  1. Katrine H. Slagsvold, Jose B.N. Moreira, Øivind Rognmo, Morten Høydal, Anja Bye, Ulrik Wisløff, Alexander Wahba. Remote ischemic preconditioning preserves mitochondrial function and activates pro-survival protein kinase Akt in the left ventricle during cardiac surgery: A randomized trial. International Journal of Cardiology, 2014; DOI: 10.1016/j.ijcard.2014.09.206

 

Intervention program helps prevent high-school dropouts

 


New research findings from a team of prevention scientists at Arizona State University demonstrates that a family-focused intervention program for middle-school Mexican American children leads to fewer drop-out rates and lower rates of alcohol and illegal drug use.

"This is the first randomized prevention trial that we're aware of to show effects on school dropout for this population," said Nancy Gonzales, Foundation Professor in the REACH Institute and Psychology Department, College of Liberal Arts and Sciences at Arizona State University.

High-school aged youth that participated in the Bridges to High School program when they were in seventh grade were more likely to value school and believe it was important for their future. They reported lower rates of substance use, internalizing symptoms such as depression, and school drop-out rates compared to adolescents in a control group, according to the study, "School Engagement Mediates Long-Term Prevention Effects for Mexican American Adolescents," published in Prevention Science.

This research is especially significant since Mexican American youth face significant barriers that lead them to have one of the highest high-school drop-out rates in the nation. The program engages families in seventh grade to stay on an academic track and plan for their future so they are prepared for high school and young adulthood. The new findings show that adolescents who are at high risk for problems such as early drinking were most likely to benefit from the program and show positive effects.

Effects of the intervention program that included 516 students and their parents in four Maricopa County (Ariz.) middle-schools were found during the high-school years for participants who completed the program.

"The program has something to offer for all students, but our research shows those who need the program the most benefit the most," Gonzales said.

Key elements consist of students working with peers and facilitators to explore the value of education, identify and affirm personal goals and values, and learn strategies to cope with adolescent problems and difficult life challenges.

Parents also work with facilitators to keep communication with their children positive by providing support, monitoring and limit-setting that adolescents need.

Ema Jauregui realized many benefits in her students when the program was implemented in her classroom when she was a middle-school teacher at Estrella Middle School in Phoenix.

"The program brought in parents and students to work side by side. It really reinforces education for the students and the program is very easy to implement," she said. "It moves the focus from just discipline to educational needs and problem solving. When kids see that their parent cares about education, they see more value in it."

Jauregui saw parents and children develop positive communication skills, even witnessing the first time a child and parent had hugged during the youth's teenage years.

Among the program's aims are to strengthen core competencies that allow youth to thrive, even when they are faced with adversity.

"Research findings support an assumption of the Bridges program that middle school is an opportune time to strengthen competencies and to motivate parents to provide the guidance and support that youth need to stay on a good path through adolescence," said Gonzales, the principal investigator for the study. Contributors include Associate Professor Larry Dumka, of the ASU T. Denny Sanford School of Social and Family Dynamics; Professor Roger Millsap, ASU Assistant Research Professor Anne Mauricio, and graduate student Jessie Wong of the ASU Psychology Department and REACH Institute (formerly the Prevention Research Center) in the College of Liberal Arts and Sciences; and Postdoctoral Fellow Russell Toomey, assistant professor at Kent State University.

The Bridges to High School research team has recently been awarded a new grant from the National Institute of Drug Abuse to focus on long term sustainability of the program in Title 1 schools.

"Now that we understand the core components that account for long-term effects of the program, we can redesign a next generation program that fits the needs of families and schools that have limited resources," Gonzales said. "We want to ensure that more families have this opportunity."


Story Source:

The above story is based on materials provided by Arizona State University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Nancy A. Gonzales, Jessie J. Wong, Russell B. Toomey, Roger Millsap, Larry E. Dumka, Anne M. Mauricio. School Engagement Mediates Long-Term Prevention Effects for Mexican American Adolescents. Prevention Science, 2014; DOI: 10.1007/s11121-013-0454-y

 

Endurance athletes at risk of swimming-induced pulmonary oedema

Endurance athletes at risk of swimming-induced pulmonary oedema


Endurance athletes taking part in triathlons are at risk of the potentially life-threatening condition of swimming-induced pulmonary oedema. Cardiologists from Musgrove Park Hospital, Taunton, writing in the Journal of the Royal Society of Medicine, say the condition, which causes an excess collection of watery fluid in the lungs, is likely to become more common with the increase in participation in endurance sports. Increasing numbers of cases are being reported in community triathletes and army trainees. Episodes are more likely to occur in highly fit individuals undertaking strenuous or competitive swims, particularly in cold water.

Dr David MacIver, lead author, said: "Swimming-induced pulmonary oedema is a well-documented but relatively rare condition that may be misdiagnosed. If an accurate diagnosis and appropriate advice are not given individuals are at increased risk of future life threatening episodes and drowning."

Dr MacIver and colleagues suggest that the unique combination of strenuous swimming, cold water and a highly trained individual can lead to a mismatch in the ventricles' stroke volume as the heart beats, resulting in the accumulation of fluid in the lungs.

"If the athlete is in open water and unable or unwilling to rest while there is ongoing stroke volume difference, pulmonary oedema can take place with potentially fatal consequences," said Dr MacIver. "An increased awareness of the risk of swimming-induced pulmonary oedema among participants, organisers and medical personnel is important, especially as many may have swum before in the same conditions without experiencing symptoms."


Story Source:

The above story is based on materials provided by SAGE Publications. Note: Materials may be edited for content and length.


Journal Reference:

  1. H. Casey, A. G. Dastidar, D. MacIver. Swimming-induced pulmonary oedema in two triathletes: a novel pathophysiological explanation. Journal of the Royal Society of Medicine, 2014; DOI: 10.1177/0141076814543214

 

New dent in HIV-1's armor: promising target for HIV/AIDS treatment

 


From left: Katherine Jones, Salk professor, and first authors Yupeng Chen and Lirong Zhang

Like a slumbering dragon, HIV can lay dormant in a person's cells for years, evading medical treatments only to wake up and strike at a later time, quickly replicating itself and destroying the immune system.

Scientists at the Salk Institute have uncovered a new protein that participates in active HIV replication, as detailed in the latest issue of Genes & Development. The new protein, called Ssu72, is part of a switch used to awaken HIV-1 (the most common type of HIV) from its slumber.

More than 35 million people worldwide are living with HIV and about a million people die a year due to the disease, according to the World Health Organization. There is no cure, and while regular medication makes the disease manageable, treatment can have severe side effects, is not readily available to everyone and requires a regiment that can be challenging for patients to adhere to.

The team began by identifying a list of 50 or so proteins that interact with a well-known protein HIV creates called Tat.

"The virus cannot live without Tat," says Katherine Jones, Salk professor in the Regulatory Biology Laboratory and senior author of the study.

Tat acts as a lookout in the cell for the virus, telling the virus when the cellular environment is favorable for its replication. When the environment is right, Tat kicks off the virus' transcription, the process by which HIV reads and replicates its building blocks (RNA) to spread throughout the body.

One of the proteins on the list that caught Jones' eye was Ssu72 (a phosphatase). This enzyme had been shown in yeast to affect the transcription machinery. Sure enough, her team found that Ssu72 binds directly to Tat and not only begins the transcription process, but also creates a feedback loop to ramp up the process.

"Tat is like an engine for HIV replication and Ssu72 revs up the engine," says Lirong Zhang, one of the first authors and a Salk researcher. "If we target this interaction between Ssu72 and Tat, we may be able to stop the replication of HIV."

The findings were surprising to the team because Tat, a relatively small protein, was previously thought to have a simpler role. Jones' lab previously discovered the CycT1 protein, another critical protein that Tat uses to begin the steps of replicating the virus. "After all these years, we thought that Tat only had this one partner (CycT1), but when we looked at it a bit harder, we found that it also binds and stimulates the Ssu72 phosphatase, which controls an immediately preceding step to switch on HIV," she said.

CycT1 is needed for normal cell function, so it may not be an ideal anti-viral target. However, the team found that Ssu72 is not required for making RNA for most host cell genes in the way it is used by HIV, making it a potentially promising target for drug therapy.

"Many proteins that Tat interacts with are essential for normal cellular transcription so those can't be targeted unless you want to kill normal cells," says co-first author Yupeng Chen, a Salk researcher. "Ssu72 seems to be different -- at least in the way it is used by HIV."

Now that the team knows the protein is specifically required for HIV transcription, they next plan to investigate how they can target the protein, for example by inhibiting Ssu72's ability kick off the transcription process. They are also examining whether latent HIV infections result from low levels of Ssu72 in resting T cells. And stay tuned: the lab is excited about checking other new host cell partners of Tat that were identified in this study.

Wireless Yardarm Sensor monitors firearm use in real time

 

The Yardarm Sensor fits into the grip of a firearm to monitor use in real time

The Yardarm Sensor fits into the grip of a firearm to monitor use in real time

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Anytime a police officer draws their weapon, it's likely to be a tense, confusing situation where split second decisions can be the difference between life and death. In an attempt to reduce some of the confusion, Yardarm has developed a wireless sensor that allows firearms to be tracked and monitored in real time thanks to a small electronics package that fits into the weapon's grip.

Developed by Capitola, California-based Yardarm Technologies, the Yardarm Sensor is billed as the "world’s first wireless sensor for firearms,” and is designed not just for the law enforcement market, but also private security firms and the military. The company says the device’s purpose is to not only improve the safety of officers on duty, but also build public confidence that weapons are being used responsibly.

The induction-charged sensor sits in the bulge in the weapon’s handgrip behind the magazine. The streamlined unit contains a programmable microcontroller, a magnetometer, accelerometer, and gyroscope. These feed into a Bluetooth transmitter that pairs the device with the user's smartphone, which is turn connects to the device to the Yardarm Cloud where it is encrypted before being sent on to the user's superior or the organization's command center.

Diagram of the Yardarm system

According to Yardarm, the Sensor integrates with existing systems and connects to computer aided dispatch (CAD) centers, real-time crime centers (RTCC), smartphones, tablets, or laptops.

The purpose of the Yardarm Sensor is to send real-time alerts whenever an incident involving an officer’s firearm occurs; even if the officer is incapacitated. The device lets the command center know when the firearm leaves its holster, where it is, when it is fired, and when the firearm leaves the officer's person. It can even record the direction of the weapon’s fire and provide evidence for crime scene investigations.

The Yardarm Sensor is actually an evolution – or devolution – of the company's Yardarm Safety First system unveiled in prototype form at the 2013 CTIA Conference in Las Vegas in May of last year. This technology allowed gun owners to remotely engage or disengage the trigger safety on their firearms from anywhere in the world. Like the Yardarm sensor, it also provided the current location of the weapon and sent an alert if it was handled or moved.

However, with "smart gun" technology falling foul of the National Rifle Association (NRA), which argued that they could infringe second amendment rights and eventually lead to a government ban of all guns that didn't posses smart gun technology, Yardarm was forced to rethink its strategy. This is why the company is targeting the law enforcement, private security and military markets rather than private gun owners.

The company says its Yardarm Sensor will complete field testing this year and will undergo final market trials early next year, with the first deliveries to follow shortly after. The price of the system has not yet been released.

 

Source: Yardarm