terça-feira, 14 de outubro de 2014

A long-touted health-care revolution may at last be about to arrive

 

Oct 11th 2014 | | From the print edition

THE idea of telemedicine—health care provided using telecommunications equipment—has a lengthy history. Radio News, an American magazine, devoted its cover to a patient at home consulting a doctor in his surgery via a television link as long ago as 1924. When NASA began monitoring astronauts in space in the 1960s, fantasy became reality. It has been touted as health care’s future ever since.

But even smartphones and tablets have failed to usher in the telemedicine revolution: most health care still happens face to face. Now, enthusiasts think the wait is nearly over. Governments have been slow to embrace an approach that could improve coverage and outcomes, as well as saving money. But they are under increasing pressure from ageing populations and a surge in chronic diseases, just as public budgets are being squeezed.

At an industry conference in Rome on October 7-8th, participants discussed the problems that must be solved if telemedicine’s day is to come. They include redesigning laws and payment systems set up for face-to-face care, and finding ways to keep patients’ data secure and private.

In America, the world’s largest health-care market, states license doctors. Jurisdiction depends on the patient’s location, not the doctor’s—so doctors must be licensed in all states where they have patients, and meet care standards that René Quashie, a health-care lawyer, says are “complicated, incoherent and sometimes contradictory”.

The situation in the European Union is simpler: countries may not pass laws that would stop doctors practising telemedicine, and doctors need only be licensed in one country to practise in all. But member states do not agree on whether to pay for care that is administered remotely; some, including Germany, rarely pay for it at all.

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In America only 21 states mandate that telemedicine be compensated at the same rate as face-to-face care. At the federal level, the Veterans Administration has embraced telemedicine whereas Medicare, the public-health programme for the elderly, largely ignores it. But private employers and insurers are increasingly paying for telemedicine, encouraged by a shift to paying doctors for packages of care rather than per service. This has “opened the door” to remote care, says Jonathan Linkous of the American Telemedicine Association.

Telemedicine is more than a Skype chat between doctor and patient, says Michael Young, who works on remote care for the University of North Carolina. The technology can look similar but the need for security and privacy is greater. Earlier this year the FBI warned American health-care providers that their cyber-security systems were not up to snuff. Electronic versions of sensitive documents such as X-rays or doctors’ notes must be as secure as paper ones. That is hard when they are flying through the ether. In August one of America’s biggest hospital groups said Chinese hackers had stolen data on 4.5m patients.

Some small countries are in the vanguard. Israel’s health-care system is fully digitised: all doctors use electronic medical records, and patients have access to their data. Doctors can write repeat prescriptions and refer patients to specialists over the internet. The health ministry noticed an uptick in telemedicine in 2010 and introduced relatively lax guidelines in 2012.

China is spending billions on health-care reform, with a focus on telemedicine. But keen interest is no guarantee of success in any country. “If you have a chaotic system and add technology, you get a chaotic system with technology,” says Peteris Zilgalvis, a health official at the European Commission. Telemedicine may even increase costs if it is added to old routines rather than replacing them. There is little evidence of its cost-effectiveness, says Marc Lange of the European Health Telematics Association, because studies simply lump it on top of standard care.

Lights, camera, interaction

Some doctors have been reluctant to embrace telemedicine, says Nils Kolstrup, a Norwegian doctor, fearing it may lessen their authority by making it easier for patients to seek advice elsewhere. Patients, too, may feel they are being fobbed off with second-best, and governments worry that it could stimulate frivolous demand.

So countries where provision is currently limited or non-existent may be quickest to move. Rwanda, for example, is short of oncologists, so American specialists consult on difficult cases. Doctors at the Cleveland Clinic look at tumours from several African countries. But if telemedicine is to take off, big, rich countries must embrace it—not least because that is where the money is.

From the print edition: International

Snap 2014-10-14 at 08.54.13

Revving up fluorescence for superfast LEDs

 


This is an artist's representation of light trapped between a silver nanocube and a thin sheet of gold. When fluorescent molecules -- shown in red -- are trapped between the two, they emit photons up to 1,000 times faster than normal.

Duke University researchers have made fluorescent molecules emit photons of light 1,000 times faster than normal -- setting a speed record and making an important step toward realizing superfast light emitting diodes (LEDs) and quantum cryptography.

This year's Nobel Prize in physics was awarded for the discovery of how to make blue LEDs, allowing everything from more efficient light bulbs to video screens. While the discovery has had an enormous impact on lighting and displays, the slow speed with which LEDs can be turned on and off has limited their use as a light source in light-based telecommunications.

In an LED, atoms can be forced to emit roughly 10 million photons in the blink of an eye. Modern telecommunications systems, however, operate nearly a thousand times faster. To make future light-based communications using LEDs practical, researchers must get photon-emitting materials up to speed.

In a new study, engineers from Duke increased the photon emission rate of fluorescent molecules to record levels by sandwiching them between metal nanocubes and a gold film.

The results appear online October 12 in Nature Photonics.

"One of the applications we're targeting with this research is ultrafast LEDs," said Maiken Mikkelsen, an assistant professor of electrical and computer engineering and physics at Duke. "While future devices might not use this exact approach, the underlying physics will be crucial."

Mikkelsen specializes in plasmonics, which studies the interaction between electromagnetic fields and free electrons in metal. In the experiment, her group manufactured 75-nanometer silver nanocubes and trapped light between them, greatly increasing the light's intensity.

When fluorescent molecules are placed near intensified light, the molecules emit photons at a faster rate through an effect called Purcell enhancement. The researchers found they could achieve a significant speed improvement by placing fluorescent molecules in a gap between the nanocubes and a thin film of gold.

To attain the greatest effect, Mikkelsen's team needed to tune the gap's resonant frequency to match the color of light that the molecules respond to. With the help of co-author David R. Smith, the James B. Duke Professor and Chair of Electrical and Computer Engineering at Duke, they used computer simulations to determine the exact size of the gap needed between the nanocubes and gold film to optimize the setup.

That gap turned out to be just 20 atoms wide. But that wasn't a problem for the researchers.

"We can select cubes with just the right size and make the gaps literally with nanometer precision," said Gleb Akselrod, a postdoc in Mikkelsen's lab and first author on the study. "When we have the cube size and gap perfectly calibrated to the molecule, that's when we see the record 1,000-fold increase in fluorescence speed."

Because the experiment used many randomly aligned molecules, the researchers believe they can do even better. They plan to design a system with individual fluorescent molecule placed precisely underneath a single nanocube. According to Akselrod, they can achieve even higher fluorescence rates by standing the molecules up on edge at the corners of the cube.

"If we can precisely place molecules like this, it could be used in many more applications than just fast LEDs," said Akselrod. "We could also make fast sources of single photons that could be used for quantum cryptography. This technology would allow secure communication that could not be hacked -- at least not without breaking the laws of physics."

This work was supported by the Lord Foundation of North Carolina and the Air Force Office of Scientific Research (Contract No. FA9550-12-1-0491).


Story Source:

The above story is based on materials provided by Duke University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Gleb M. Akselrod, Christos Argyropoulos, Thang B. Hoang, Cristian Ciracì, Chao Fang, Jiani Huang, David R. Smith, Maiken H. Mikkelsen. Probing the mechanisms of large Purcell enhancement in plasmonic nanoantennas. Nature Photonics, 2014; DOI: 10.1038/nphoton.2014.228

 

Duke University. "Revving up fluorescence for superfast LEDs." ScienceDaily. ScienceDaily, 12 October 2014. <www.sciencedaily.com/releases/2014/10/141012134843.htm>.

Hands-on: Is Samsung's bold Gear S ahead of the smartwatch curve?

 

Gizmag goes hands-on with Samsung's boldest smartwatch to date, the Gear S

Gizmag goes hands-on with Samsung's boldest smartwatch to date, the Gear S

Image Gallery (59 images)

Last week we told you about Samsung's latest smartwatch, the Gear S. With a curved display and built-in 3G wireless, it's certainly a bold step forward. But what's it like to actually use? Read on, as Gizmag goes wrists-on with the Samsung Gear S.

The Gear S is unmistakably bold, but it's also walking a fine line. On one hand, it has a gorgeous and spacious 2-in curved screen. The Super AMOLED display looks terrific and the curved aesthetic is a pleasure to swipe and tap. It gives you much more real estate than any mainstream smartwatch to date – and that alone could open some interesting doors.

On the other hand, this sucker takes the tech producty look that has been so common in smartwatches, and pushes it to a new extreme. Wear this thing in public, and you're sure to get some looks. I personally think it looks pretty cool, but it's also a huge departure from classic timekeeping watches. Dick Tracy? More like George Jetson.

Samsung Gear S (Photo: Will Shanklin/Gizmag.com)

It's quite possible that most customers aren't ready for a watch that looks like this. Or, on the other hand, maybe customers just need to know that it packs in enough cool features to justify its sci-fi appearance. That's where the Gear S has more potential than previous smartwatches.

Nike+ app on the Samsung Gear S (Photo: Will Shanklin/Gizmag.com)

Though it runs a newer version of the same Tizen software, using the Gear S is very different from using any of the older Samsung watches. And it all goes back to that display. It's going to raise the bar for what's possible on a smartwatch.

Samsung Gear S (Photo: Will Shanklin/Gizmag.com)

From where I stand now, I'd say the Gear S' killer feature is its virtual keyboard. It's a bit strange rapping out texts or emails on a curved 2-in screen, but Samsung's auto-correct seems to be quite good. In my testing during the hands-on session, it almost always corrected my gibberish into exactly what I was trying to type.

A Samsung rep also tells me that the watch will support third-party keyboards. So, though the stock Samsung one doesn't have a Swype-like trace feature, we'll surely see alternatives that will (perhaps from companies like SwiftKey or Swype itself).

Samsung Gear S with the Gear 2 Neo (Photo: Will Shanklin/Gizmag.com)

Back to that curved screen. Yes, it's huge for a watch. And yes, this design is going to be way too radical for some people. But it's also a joy to use. It's a lot like the Gear Fit's screen, only much bigger, more curved and attached to a more powerful device.

We'll need to spend more time with the Gear S before jumping to conclusions. But, from where I stand now, I think Samsung has hit a pretty nice balance of packing in smartphone-like space and power – but without going too ridiculously crazy with the design (though opinions will undoubtedly vary on that point).

Samsung Gear S (Photo: Will Shanklin/Gizmag.com)

The Tizen UI is similar to what we've seen on older Gear watches, but it's more mature on the Gear S. From the main clock face, you'll find widgets lined up to your right. Notifications live permanently on the left. Below the main screen is an app drawer. This latest version of the Tizen software is inching closer to being like a smartphone OS.

Samsung Gear S (Photo: Will Shanklin/Gizmag.com)

So what about the 3G wireless and that SIM card slot that you see above? Well, I couldn't get a cut-and-dry answer from Samsung about what features will be available without a paired smartphone, and which will require the phone. The impression I get is that, right now, there is no answer. Apparently the point hasn't yet been decided (I suspect carrier demands and politics are at play). But we do know that at least some key features will work without having your phone around.

The gist that I got from Samsung's reps is that, despite its 3G radio, the Gear S isn't designed to replace your phone. It's still a companion device. But, in a pinch, it can work without one ... at least partially.

A lot is still fuzzy there, so we should consider the standalone wireless factor a question mark at this point. We'll be keeping an eye on this when the watch launches.

Samsung Gear S (Photo: Will Shanklin/Gizmag.com)

In poking through the watch's settings, I noticed that there were options for calling or sending texts from either your paired phone's number or from the Gear's own number (above). There were also options for forwarding calls from your phone to the Gear. When I asked a Samsung rep about this, I was told that the software isn't final, so these options may or may not be in the final shipping version. Perhaps it will also vary from carrier to carrier.

Samsung also hasn't revealed anything about pricing, but a company rep hinted to me that it may cost more than previous Gear watches. With 3G, built-in GPS and that large curved screen, I guess that shouldn't be too surprising. My guess is that the Gear S will land in the US$350-550 range. In the US, maybe we'll even see carriers sell it subsidized with a contract or installment plan (that's completely speculation on my part, by the way).

Samsung Gear S (Photo: Will Shanklin/Gizmag.com)

As for that built-in GPS, we could only test it so much in an indoor hands-on area. But it looks like exactly what you'd expect out of any navigation app. It's Nokia's Here, it's on the Gear and it's designed for pedestrian travel. Until we get our hands on a review unit, that's the long and short of it.

Samsung Gear S (Photo: Will Shanklin/Gizmag.com)

Of the four products Samsung revealed today, the Gear S was the one I gravitated towards the most. It's going to make a very interesting alternative to Android Wear (and perhaps the iWatch). And while I still think most people will prefer watches that look a bit less ... futuristic, I've always appreciated Samsung's full-throttle approach to this space. Once we get a review unit in house, this is going to be, at the very least, one hell of a fun device to play with.

For more on today's announcements, you can hit up our hands-ons with the Galaxy Note 4 and Galaxy Note Edge. And for more on the Gear S, you can see how it compares to Samsung's five previous smartwatches.

Snap 2014-09-11 at 19.35.16

 

Green tea nanocarrier delivers cancer-killing drugs more effectively

 

Green tea has been used for the first time to deliver cancer-killing drugs (Photo: Shutter...

Green tea has been used for the first time to deliver cancer-killing drugs (Photo: Shutterstock)

Many of us drink green tea for its wonderful health benefits, including proven antioxidant, antimicrobial, anti-aging and anti-cancer properties. Now, researchers in Singapore have taken its cancer-fighting properties to the next level, developing a green tea-based nanocarrier that encapsulates cancer-killing drugs. It is the first time green tea has been used to deliver drugs to cancer cells, with promising results. Animal studies show far more effective tumor reduction than use of the drug alone while significantly reducing the accumulation of drugs in other organs.

The new drug delivery system, developed at the Institute of Bioengineering and Nanotechnology (IBN) of A*STAR, uses epigallocatechin gallate (EGCG), a powerful antioxidant and catechin found in green tea and used therapeutically to treat cancer and other disorders.

"We have developed a green tea-based carrier in which the carrier itself displayed anti-cancer effect and can boost cancer treatment when used together with the protein drug," says Dr Motoichi Kurisawa, IBN Principal Research Scientist and Team Leader.

One of the main drawbacks of chemotherapy is that it also kills healthy cells in surrounding tissues and organs. Carriers allow more accurate treatment, acting like homing missiles that target diseased cells and release cancer-destroying drugs. However, the amount of the drug they can deliver is limited so more carriers need to be administered for treatment to be effective. Current carriers are made of materials that at best offer no therapeutic value and at worst may have adverse effects when used in large quantities, so the green tea-based carrier is an exciting development.

Green tea nanocarrier delivers cancer-killing drugs more effectively

The carrier uses a core made of an oligomer of EGCG to enclose cancer-destroying drugs. The shell of the carrier is made of PEG, a molecule which camouflages the carrier and prevents the immune system from destroying it before it reaches its target.

Animal studies using the green tea-based nanocarrier loaded with Herceptin, a drug used to treat breast cancer, delivered promising results. Twice as much Herceptin accumulated in cancer cells than if the drug had been used alone, enabling more effective tumor targeting and reduced tumor growth. On the other hand, the level of Herceptin in surrounding organs was significantly lower, with a 70 percent reduction in the liver and kidneys and a 40 percent reduction in the lungs.

The IBN team is developing the technology for clinical applications.

The research has been published in nature nanotechnology.

Source: IBN (PDF)

 

9 Awesome Infographics for Graphic Designers

 

We just released our biggest post so far. Read all about Mattia's 'No flying for a year' experience in this post!

Published by Brian Morris on January 28, 2013 in Infographic 10 images

As a graphic designer, you’ve probably designed at least a few infographics for your clients – or even for fun.  You can create (and sell) infographics for any topic or industry, which means infographics can be a lucrative source of income.  Some designers make a full-time living designing infographics alone.  And while infographics always require the talents of a graphic designer, how many infographics have you seen that feature graphic designers?  The following 10 awesome infographics were made by graphic designers, for graphic designers.  Follow the links to view the full infographics.  Enjoy!

1. Psychology of Color

Learn what different colors represent and what emotions they stir, and when and how to use them in your own designs.

Psychology of Color

2. Elements of Design

This infographic serves as a quick reference for the basic elements of design, complete with tips for how and why each should be considered when creating any design.

Elements of Design

 

3. Graphic Designer’s Roadmap

Want to be a better, more successful, more inspired graphic designer?  This infographic serves as a roadmap to all of these things.

Graphic Designer’s Roadmap

4. What Your Web Design Says About You

Your favorite fonts, colors, and other design elements reveal a lot about your personality, goals and dreams. 

5. Freelance to Freedom.

How do you get out from under your bosses’ thumb, grow your freelance business and eventually life on a good income with minimal effort? 

6. Facts About Graphic Design Careers

How much do other graphic designers make?  Where are the best jobs located?  Learn the answers to these questions and more from this graphic design infographic.

Facts About Graphic Design Careers

7. State of Graphic Design

This infographic reveals the results of polling the world’s most successful graphic designers to determine what, in fact, is necessary to be a truly successful graphic designer

State of Graphic Design

8. Creative Salaries

What to know what graphic designers make?  How about creative directors?  Learn more about income differences and gaps revealed in a 2012 survey among creative professionals with this infographic.

Creative Salaries

9. Anatomy of a Graphic Designer

A humorous look at what makes a graphic designer, a graphic designer.

Anatomy of a Graphic Designer

by Glantz Design

 

Snap 2014-10-14 at 05.00.33

Construction of Royal Navy's new River class OPVs gets underway

 

Artist's concept of HMS Forth, which is now under construction

Artist's concept of HMS Forth, which is now under construction

Image Gallery (9 images)

BAE Systems has begun construction of the first of the Royal Navy’s three new River class Batch 3 Offshore Patrol Vessels (OPV). During a ceremony at BAE Systems Surface Ships’ Govan facility in Glasgow, Bernard Gray, the Ministry of Defence’s (MoD) Chief of Defence Material, activated a plasma cutting machine, which sliced through first plate of steel for HMS Forth. The ship will be the first in the Royal Navy to incorporate the state-of-the-art Shared Infrastructure operating system in its construction.

HMS Forth and her two sister ships are based on a design already used in ships built by BAE for the Brazilian Navy and the Royal Thai Navy, but which has now been upgraded and adapted for Britain’s requirements. One key element to the new River class is the Shared Infrastructure system, which is already being retrofitted to the helicopter carrier HMS Ocean. It’s designed to integrate the hardware of the ship’s combat and management systems, so they can all be accessed from a single console instead of from a series of dedicated consoles.

According the BAE, Shared Infrastructure is scheduled to be deployed across the Royal Navy’s entire surface fleet over the next decade. It is expected to significantly reduce operating costs while freeing up more space below decks and in the stores thanks to fewer spare parts being needed at sea to repair multiple console types.

Artist's concept of the Royal Navy's new OPVs

When construction is completed, HMS Forth and the other two planned OPVs will join the previous five River class ships that will replace the Island and Castle-class patrol vessels. Larger and longer than previous ships in their class, the Batch 3s and the rest of the River class will be used mainly for Fishery Protection Squadron and Economic Exclusion Zone (EEZ) patrol, though they are designed for global deployment, with one in the class having been assigned to protect the Falkland Islands.

The new River class ships displace 2,000 tonnes (2,204 tons), are 90.5 m (297 ft) long and have a draft of 3.8 m (12.4 ft). They’re powered by two Ruston 12RK 270 diesel engines that give them a cruising speed of 24 knots (27 mph, 44 km/h), a range of 5,500 nmi (6,300 mi, 10,200 km), and an endurance of 35 days at sea. In addition to their complement of 36, they can also carry 20 troops, and their longer length allows them to accommodate a Merlin helicopter on the flight deck, as well as a 30mm DS30B gun forward.

"We've kept many of the engineering qualities that have made the [previous batch] River class OPVs so successful and reliable, and enhanced them with a design that is larger, more efficient, and more capable,” says Iain Stevenson, Head of the Offshore Patrol Vessel Programme BAE Systems Naval Ships. “This design is tried and tested and already in service with the Brazilian Navy and Royal Thai Navy, who are operating similar versions of these ships. For the Royal Navy, our engineering teams have modified this proven design, ensuring that it meets the demanding UK requirements, demonstrating just how flexible the design of the ship is.”

HMS Forth is scheduled for delivery to the Royal Navy in 2017.

 

Source: BAE Systems