quinta-feira, 16 de outubro de 2014

iPad Air 2 is thinner, starts at $500, £400, AU$620; has Touch ID (hands-on)

 

October 16, 2014 10:42 AM PDT

The Apple iPad Air 2 starts at $499 (£399, AU$620), finally includes Apple's TouchID fingerprint sensor and at 6.1 millimeters thick, is -- according to Apple -- currently the world's thinnest tablet. The tablet weighs in at 0.96-pound or 437g -- 0.98-pound/444g for cellular -- which is about 0.07-pound/32g lighter than the original iPad Air.

iPad Air 2 hands-on (pictures) See full gallery

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Pre-orders start Friday, October 17, and the tablet starts shipping the following Friday, October 24. Wi-Fi model pricing looks like this: $499 for 16GB; $599 for 64GB; $699 for 128GB. Cellular models are more expensive, as we'd expect: $629 for 16GB; $729 for 64GB; $829 for 128GB. (UK pricing for these options will be added as soon as it's made available.)

The Air 2 gets a huge upgrade in potential graphics performance, thanks to the new A8X CPU, custom-made for the tablet. According to Apple, the new chip has a second-generation 64-bit architecture, houses 3 billion transistors and compared to the iPhone 6's A8 chip, has a 40 percent faster CPU while its GPU is 2.5 times faster. As a gamer finding himself gaming more and more on a tablet, those details excite me the most.

Here's a hands-on look at the new Air 2 from CNET Section Editor Dan Ackerman. He notes -- although it's difficult to tell in the video -- that the tablet is in fact ever-so-much thinner than last year's Air.

The tablet includes the new M8 motion coprocessor, last seen in the iPhone 6 and 6 Plus. The chip tracks motion, calibrates sensors, and acts as a barometer.

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Tim Stevens/CNET

Don't expect people to stop using their iPads to take pictures anytime soon. The iSight camera is now an 8-megapixel shooter -- up from 5-megapixel on the Air -- with a burst mode for taking a bunch of photos in succession. The rear camera also support time-lapse, slow motion, and 1080p video recording.

The new FaceTime camera hasn't been left out of the upgrade goodies. It now does burst selfies and has improved face detection.

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Tim Stevens/CNET

Wi-Fi is purportedly faster with Apple claiming a 2.8X speed increase and 802.11ac support.

The new tablet ships with .1 and includes support for Apple Pay, Apple's new payment system. However since there's no NFC chip inside, you (thankfully?) won't be seeing it used at retail. It will be used for in-app purchases instead.

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Less space equals less light bouncing around, which ultimately leads to less glare. James Martin/CNET

Apple addresses glare on the new tablet by making some changes to the way it's manufactured. It's gone to some lengths to make the space between the different components smaller, thereby reducing the amount of space for light to move through. The result is a tablet that should significantly reduce the amount of glare seen when using the tablet in sunlight. There's also an anti-reflective coating on the screen.

Apple appears to have checked most of the expected upgrade boxes. The A8X chip is by far the most exciting upgrade, but will likely only lead to better graphics in games and faster overall performance. If the iPad has never appealed to you as a product, the Air 2 probably won't change your mind. However, if you know what you're getting into, the Air 2's upgrades look to deliver palpable advantages over any tablet before it. Look for a full review soon.

Snap 2014-10-16 at 20.41.02

Um bate-papo ao cair da noite.


Eu me propus de quando em quando postar algumas idéias próprias à respeito de qualquer tema que me aflore à mente. Há pouco li na Internet um artigo sobre notáveis diferenças de idade entre casais famosos. Não é muito comum que isso aconteça, porém nada garante que uma união entre casais cujas idades tenham uma diferença desejável de uns 10 anos, será duradoura, ou sem conflitos.

Como já comentei acima que grandes diferenças de idade não seja um fato corriqueiro, existe sempre uma conveniência nas uniões desse tipo. Vamos imaginar um casal em que o homem tenha 65 anos e a mulher, 35. São 30 anos de diferença. Mas estávamos comentando no início que nota-se isso entre “casais famosos”. Por que? Isso quer dizer que entre casais comuns, e não ricos como os famosos, isso não seria problema?

Trata-se de uma questão moral, e não de famosidade e dinheiro, que via de regra sempre acompanha a fama. De uma maneira geral, sem considerarmos fama ou dinheiro, o que interessa é que ambos gozem de uma boa saúde, que não tenham vícios, que sigam um estilo de vida saudável.  Resumindo, essa questão social como tantas outras  é algo que irá sendo corrigida à medida em que a sociedade seja melhor amparada por medidas governamentais na área da sáude e educação, e que os governos destinem verbas mais generosas para isso.

O mundo tem hoje questões muito mais importantes para serem discutidas e resolvidas na medida em que a Ciencia avance. Não se pode pretender que entre casais famosos e casais comuns ocorra uma união absolutamente dentro de normas éticas. Pelo menos não nos tempos atuais. É desejável que isso e tudo o mais referente à sociedade seja publicada e discutida, visando tornar os costumes mais uniformes e salutares dentro dos valores morais e religiosos, porém levando-se em conta a realidade contemporânea.

José S. de Melo.  


Precision printing: Unique capabilities of 3-D printing revealed

 


ORNL researchers have demonstrated the ability to precisely control the structure and properties of 3-D printed metal parts during formation. The electron backscatter diffraction image shows variations in crystallographic orientation in a nickel-based component, achieved by controlling the 3-D printing process at the microscale.

Researchers at the Department of Energy's Oak Ridge National Laboratory have demonstrated an additive manufacturing method to control the structure and properties of metal components with precision unmatched by conventional manufacturing processes.

Ryan Dehoff, staff scientist and metal additive manufacturing lead at the Department of Energy's Manufacturing Demonstration Facility at ORNL, presented the research this week in an invited presentation at the Materials Science & Technology 2014 conference in Pittsburgh.

"We can now control local material properties, which will change the future of how we engineer metallic components," Dehoff said. "This new manufacturing method takes us from reactive design to proactive design. It will help us make parts that are stronger, lighter and function better for more energy-efficient transportation and energy production applications such as cars and wind turbines."

The researchers demonstrated the method using an ARCAM electron beam melting system (EBM), in which successive layers of a metal powder are fused together by an electron beam into a three-dimensional product. By manipulating the process to precisely manage the solidification on a microscopic scale, the researchers demonstrated 3-dimensional control of the microstructure, or crystallographic texture, of a nickel-based part during formation.

Crystallographic texture plays an important role in determining a material's physical and mechanical properties. Applications from microelectronics to high-temperature jet engine components rely on tailoring of crystallographic texture to achieve desired performance characteristics.

"We're using well established metallurgical phenomena, but we've never been able to control the processes well enough to take advantage of them at this scale and at this level of detail," said Suresh Babu, the University of Tennessee-ORNL Governor's Chair for Advanced Manufacturing. "As a result of our work, designers can now specify location specific crystal structure orientations in a part."

Other contributors to the research are ORNL's Mike Kirka and Hassina Bilheux, University of California Berkeley's Anton Tremsin, and Texas A&M University's William Sames.

The research was supported by the Advanced Manufacturing Office in DOE's Office of Energy Efficiency and Renewable Energy.


Story Source:

The above story is based on materials provided by Oak Ridge National Laboratory. Note: Materials may be edited for content and length.


Oak Ridge National Laboratory. "Precision printing: Unique capabilities of 3-D printing revealed." ScienceDaily. ScienceDaily, 15 October 2014. <www.sciencedaily.com/releases/2014/10/141015130641.htm

 

O PC que eu montei na parede

 

Eu prometi postar as imagens do computador montado na parede, já com quase tudo concluido, faltando ainda ajustar o pequeno ventilador à direita, que está um pouco fora da posição ideal para refrigerar tanto a CPU quanto os discos rígidos.

Placa mãe ASUS com memória DDR3, USB 2.0 e 3.0, HDD SATA III (6GB/s) CPU i3, e monitor-TV Philco 24”

 

 

Pc_onthewall - B (14)

 

Pc_onthewall - B (15)

 

Pc_onthewall - B (16)

 

 

Notice : Patent Pending -  (J.Kidd…)

Surgical robot takes a cheeky approach to brain surgery

 

Patient mockup of surgical robot designed to treat epilepsy by entering the brain through ...

Patient mockup of surgical robot designed to treat epilepsy by entering the brain through the cheek (Photo: Laboratory for the Design and Control of Energetic Systems / Vanderbilt)

Conventional open surgery on the brain involves drilling openings in the skull through which to access the gray matter. But what if the part of the brain needing to be accessed is located at the bottom of the brain as is the case with treating severe epileptic seizures? Generally it means more drilling. Now engineers at Vanderbilt University have developed a surgical robot that uses an alternative point of entry – the cheek.

Treating those seeking relief from severe epileptic seizures involves drilling through the top of the head and deep into the brain to destroy a small area in the hippocampus where the seizures originate. Inspired by the through-the-cheek technique neuroscientists currently use to implant electrodes in the brain to track brain activity and locate the source of epileptic fits, a team headed by Associate Professor of Mechanical Engineering Eric Barth developed a robotic device that enters through the patient's cheek. This provides a less invasive way to access the desired area, avoiding drilling through the skull altogether.

Robotic platform designed to operate in the intense magnetic field of an MRI scanner (Phot...

The working prototype developed by the team features a 1.14 mm needle made from nickel-titanium, which is one of the few common metals compatible with MRIs. The needle works in a similar way to a mechanical pencil, with compressed air used to advance the needle segments a millimeter at a time. Concentric tubes, some of which are curved, allow the robotic platform to steer the needle and follow a curved path into the brain, with surgeons able to track its position by taking successive MRI scans.

"The systems we have now that let us introduce probes into the brain – they deal with straight lines and are only manually guided," says Associate Professor of Neurological Surgery Joseph Neimat. "To have a system with a curved needle and unlimited access would make surgeries minimally invasive. We could do a dramatic surgery with nothing more than a needle stick to the cheek."

Mechanical engineering graduate student David Comber, who is responsible for much of the design, says the accuracy of the system measured in the lab is better than 1.18 mm, which is considered accurate enough for such surgery. To keep costs down, the team also designed it so much of the system can be 3D printed.

Cut-away view of the robotic platform reveals how much of the device can be made by 3D pri...

The team will now move onto testing the robotic platform on cadavers, with Barth estimating the technology could make its way into operating rooms within the next decade.

Comber recently unveiled the working prototype in a live demonstration at the Fluid Power Innovation and Research Conference in Nashville.

Source: Vanderbilt University

 

Getting to know super-Earths: Using Hubble to study mysterious exoplanet

 

For as long as astronomers have been looking to the skies, we have had just one planetary system -- our own -- to study in depth. That means we have only gotten to know a handful of possible outcomes of the planet formation process, and we cannot say much about whether the features observed in our solar system are common or rare when compared to planetary systems orbiting other stars.

That is beginning to change. NASA's Kepler spacecraft, which launched on a planet-hunting mission in 2009, searched one small patch of the sky and identified more than 4,000 candidate exoplanets -- worlds orbiting stars other than our own sun. It was the first survey to provide a definitive look at the relative frequency of planets as a function of size. That is, to ask, 'How common are gas giant planets, like Jupiter, compared to planets that look a lot more like Earth?'

Kepler's results suggest that small planets are much more common than big ones. Interestingly, the most common planets are those that are just a bit larger than Earth but smaller than Neptune -- the so-called super-Earths.

However, despite being common in our local corner of the galaxy, there are no examples of super-Earths in our own solar system. Our current observations tell us something about the sizes and orbits of these newly discovered worlds, but we have very little insight into their compositions.

"We are left with this situation where super-Earths appear to be the most common kind of exoplanet in the galaxy, but we don't know what they're made of," says Knutson.

There are a number of possibilities. A super-Earth could be just that: a bigger version of Earth -- mostly rocky, with an atmosphere. Then again, it could be a mini-Neptune, with a large rock-ice core encapsulated in a thick envelope of hydrogen and helium. Or it could be a water world -- a rocky core enveloped in a blanket of water and perhaps an atmosphere composed of steam (depending on the temperature of the planet).

"It's really interesting to think about these planets because they could have so many different compositions, and knowing their composition will tell us a lot about how planets form," Knutson says. For example, because planets in this size range acquire most of their mass by pulling in and incorporating solid material, water worlds initially must have formed far away from their parent stars, where temperatures were cold enough for water to freeze. Most of the super-Earths known today orbit very close to their host stars. If water-dominated super-Earths turn out to be common, it would indicate that most of these worlds did not form in their present locations but instead migrated in from more distant orbits.

In addition to thinking about exoplanets, Knutson and her students use space-based observatories like the Hubble and Spitzer Space Telescopes to learn more about the distant worlds. For example, the researchers analyze the starlight that filters through a planet's atmosphere as it passes in front of its star to learn about the composition of the atmosphere. Molecular species present in the planet's atmosphere absorb light at particular wavelengths. Therefore, by using Hubble and Spitzer to view the planet and its atmosphere at a number of different wavelengths, the researchers can determine which chemical compounds are present.

To date, nearly two dozen planets have been characterized with this technique. These observations have shown that the enormous gas giant exoplanets known as hot-Jupiters have water, carbon monoxide, hydrogen, helium -- and potentially carbon dioxide and methane -- in their atmospheres.

However, right now super-Earths are the hot topic. Unfortunately, although hundreds of super-Earths have been found, only a few are close enough and orbiting bright enough stars for astronomers to study in this way using currently available telescopes.

The first super-Earth that the astronomical community targeted for atmospheric studies was GJ 1214b, in the constellation Ophiuchus. Based on its average density (determined from its mass and radius), it was clear from the start that the planet was not entirely rocky. However, its density could be equally well matched by either a primarily water composition or a Neptune-like composition with a rocky core surrounded by a thick gas envelope. Information about the atmosphere could help astronomers determine which one it was: a mini-Neptune's atmosphere should contain lots of molecular hydrogen, while a water world's atmosphere should be water dominated.

GJ 1214b has been a popular target for the Hubble Space Telescope since its discovery in 2009. Disappointingly, after a first Hubble campaign led by researchers at the Harvard-Smithsonian Center for Astrophysics, the spectrum came back featureless -- there were no chemical signatures in the atmosphere. After a second set of more sensitive observations led by researchers at the University of Chicago returned the same result, it became clear that a high cloud deck must be masking the signature of absorption from the planet's atmosphere.

"It's exciting to know that there are clouds on the planet, but the clouds are getting in the way of what we actually wanted to know, which is what is this super-Earth made of?" explains Knutson.

Now Knutson's team has studied a second super-Earth: HD 97658b, in the constellation Leo. They report their findings in the current issue of The Astrophysical Journal. The researchers used Hubble to measure the decrease in light when the planet passed in front of its parent star over a range of infrared wavelengths in order to detect small changes caused by water vapor in the planet's atmosphere.

However, again the data came back featureless. One explanation is that HD 97658b is also enveloped in clouds. However, Knutson says, it is also possible that the planet has an atmosphere that is lacking hydrogen. Because such an atmosphere could be very compact, it would make the telltale fingerprints of water vapor and other molecules very small and hard to detect. "Our data are not precise enough to tell whether it's clouds or the absence of hydrogen in the atmosphere that's causing the spectrum to be flat," she says. "This was just a quick first look to give us a rough idea of what the atmosphere looked like. Over the next year, we will use Hubble to observe this planet again in more detail. We hope those observations will provide a clear answer to the current mystery."

It appears that clouds are going to continue to pose a real challenge in studies of super-Earths, so Knutson and other researchers are working to understand the composition of the clouds around these planets and the conditions under which they form. The hope is that they will get to the point where they can predict which worlds will be shrouded in clouds. "If we can then target planets that we think should be cloud-free, that will help us make optimal use of Hubble's time," she says.

Looking to the future, Knutson says there is only one more known super-Earth that can be targeted for atmospheric studies with current telescopes. But new surveys, such as NASA's extended Kepler K2 mission and the Transiting Exoplanet Survey Satellite (TESS), slated for launch in 2017, should identify a large sample of new targets.

Of course, she says, astronomers would love to study exoplanets the size of Earth, but these worlds are just a bit too small and too difficult to observe with Hubble and Spitzer. NASA's James Webb Space Telescope, which is scheduled for launch in 2018, will provide the first opportunity to study more Earth-like worlds. "Super-Earths are at the edge of what we can study right now," Knutson says. "But super-Earths are a good consolation prize -- they're interesting in their own right, and they give us a chance to explore new kinds of worlds with no analog in our own solar system."

 

Story Source:

The above story is based on materials provided by California Institute of Technology. The original article was written by Kimm Fesenmaier. Note: Materials may be edited for content and length.


Journal Reference:

  1. Heather A. Knutson, Diana Dragomir, Laura Kreidberg, Eliza M.-R. Kempton, P. R. McCullough, Jonathan J. Fortney, Jacob L. Bean, Michael Gillon, Derek Homeier, Andrew W. Howard. HUBBLE SPACE TELESCOPENEAR-IR TRANSMISSION SPECTROSCOPY OF THE SUPER-EARTH HD 97658B. The Astrophysical Journal, 2014; 794 (2): 155 DOI: 10.1088/0004-637X/794/2/155

 

California Institute of Technology. "Getting to know super-Earths: Using Hubble to study mysterious exoplanet." ScienceDaily. ScienceDaily, 15 October 2014. <www.sciencedaily.com/releases/2014/10/141015152554.htm>.

New target for personalized brain cancer treatment: PTPRZ-MET fusion protein

 


Researchers at the University of California, San Diego School of Medicine have identified a new fusion protein found in approximately 15 percent of secondary glioblastomas or brain tumors. The finding offers new insights into the cause of this cancer and provides a therapeutic target for personalized oncologic care. The findings were published this month in the online edition of Genome Research.

Glioblastoma is the most common and deadliest form of brain cancer. The majority of these tumors – known as primary glioblastomas – occur in the elderly without evidence of a less malignant precursor. Secondary glioblastomas occur mostly in younger patients and progress from low-grade, less aggressive precursor tumors to glioblastoma, the most aggressive form of the disease.

“While genomic profiling is yielding improved understanding of primary glioblastoma, our understanding of secondary glioblastoma remains rudimentary,” said Clark Chen, MD, PhD, vice-chairman of Research and Academic Development, Division of Neurosurgery, UC San Diego School of Medicine and a principle investigator of the study. “In this study, we used a technology called RNA-Seq to study the RNA sequences derived from 272 clinical tumor specimens from patients afflicted with secondary glioblastoma or precursor forms of this tumor.”

The study revealed that the RNA sequences of brain cancers become progressively more abnormal as the tumor become more malignant. Specifically, the frequency of aberrant RNAs fusing gene sequences not normally found next to one another increased with tumor grade. Most of these fusion junctions occur in seemingly random locations. However, transcripts involving fusions of the PTPRZ and MET gene were found repeatedly in clinical specimens derived from different patients. The study estimates that 15 percent of the secondary glioblastoma harbor this fusion.

“The recurrent nature of this fusion transcript suggests that the fusion did not arise by chance. Instead, it’s likely that the fusion actively contributes to the biologic behavior of the tumor,” said Chen, who collaborates with a multidisciplinary team at UC San Diego Moores Cancer Center. “Supporting this hypothesis, we demonstrated that glioblastoma cells expressing the PTPRZ-MET fusion are more invasive and patients afflicted with these tumors showed particularly poor survival relative to other secondary glioblastoma patients.”

“One of the most important implications of the work is that inhibitors against the MET oncoprotein are available for clinical use,” said Bob S. Carter, MD, PhD, study co-author and professor of surgery and chief of Neurosurgery, UC San Diego School of Medicine. “Secondary glioblastomas harboring the PTPRZ-MET fusion may be exquisitely sensitive to these inhibitors. Matching MET inhibitors to genotype of the glioblastoma affords us a unique opportunity to personalize oncologic care.”


Story Source:

The above story is based on materials provided by University of California, San Diego Health Sciences. Note: Materials may be edited for content and length.


Journal Reference:

  1. Z.-S. Bao, H.-M. Chen, M.-Y. Yang, C.-B. Zhang, K. Yu, W.-L. Ye, B.-Q. Hu, W. Yan, W. Zhang, J. Akers, V. Ramakrishnan, J. Li, B. Carter, Y.-W. Liu, H.-M. Hu, Z. Wang, M.-Y. Li, K. Yao, X.-G. Qiu, C.-S. Kang, Y.-P. You, X.-L. Fan, W. S. Song, R.-Q. Li, X.-D. Su, C. C. Chen, T. Jiang. RNA-seq of 272 gliomas revealed a novel, recurrent PTPRZ1-MET fusion transcript in secondary glioblastomas. Genome Research, 2014; DOI: 10.1101/gr.165126.113

University of California, San Diego Health Sciences. "New target for personalized brain cancer treatment: PTPRZ-MET fusion protein." ScienceDaily. ScienceDaily, 13 October 2014. <www.sciencedaily.com/releases/2014/10/141013152652.htm>.

Immune cells in liver drive fatty liver disease, liver cancer

 

October 14, 2014

Helmholtz Zentrum München - German Research Center for Environmental Health

Immune cells that migrate to the liver and interact there with liver tissue cells get activated by metabolic stress (e.g. through lipids of a high fat diet) and drive the development of fatty liver disease, non-alcoholic steatohepatitis and liver cancer. Scientists made this discovery and thus identified the previously unknown mechanism underlying these serious and widespread diseases.


Human hepatozytes filled with lipids representing macro-vesicular steatosis in hepatocytes (arrows) and inflamed cells (arrow head) caused by chronic fat diet.

Fatty liver disease -- alongside fatty liver due to massive alcohol consumption -- is mainly caused by excessive consumption of fat and sugar combined with a lack of exercise or a sedentary life style. This is referred to as non-alcoholic fatty liver disease (NAFLD). If NAFLD becomes chronic -- e.g. through the constant uptake of high lipids and high sugar combined with lack of excercise a chronic inflammatory response is triggered in the liver tissue in addition. This can lead to non-alcoholic steatohepatitis (NASH) -- a liver disease with clear detectable pathologic alteratons of the tissue.

These liver diseases (NAFLD and NASH), along with chronic viral infections, are the most common causes of liver cancer, or hepatocellular carcinoma (HCC). In the United States, about 90 million people suffer from NAFLD. In Europe, the figure is more than 40 million, and even in threshold countries like India and China, the number of people affected is rising due to increasingly unhealthy lifestyles. More worrying, in all of the above mentioned states the numbers of NAFLD and NASH patients is constantly increasing. Consequently, the incidence of HCC resulting from NASH and NAFLD is also rising worldwide. In the United States, HCC is the fastest-growing form of cancer at the moment. No efficient causal therapy exists for HCC patients of which approximately 800,000 die every year.

T cells involved in the development of fatty liver disease, NASH and HCC

The mechanisms that cause diseases such as fatty liver disease, steatohepatitis and HCC are still not widely understood. However, immune cells, particularly CD8+ T cells and NK T cells seem to play an important role. This finding was made by a team of scientists led by Prof. Mathias Heikenwälder, Prof. Matthias Tschöp, Dr. Kerstin Stemmer, Dr. Kristian Unger, Prof. Ulrike Protzer and the working group of Dr. Hans Zischka from the Helmholtz Zentrum München together with a team headed by Prof. Percy Knolle of the Technische Universität München (TUM), Prof. Achim Weber from Zurich University Hospital and Dr. Monika Wolf, Institute of Surgical Pathology, University Hospital Zurich. The animal model which was used to examine the long-term effects of metabolic syndrome* enabled the scientists to elucidate new mechanisms that cause fatty liver disease and also show how it can develop into liver cancer.

Inflammatory events offer starting point for prevention and treatment

The scientists assume that an existing metabolic imbalance results in the activation and migration of immune cells to the liver. There, the immune cells interact with liver cells and trigger an inflammatory response that damages the liver tissue and also destabilizes the metabolic activity of the liver cells. "Initially it immune cells promote fatty liver degeneration. The inflammation, which is triggered by specific immune cells, encourages the progression of fatty liver pathology and causes NASH to develop. These processes are the basis for liver cell degeneration, which can cause HCC," explains Prof. Heikenwälder, who led the study. "Our results provide completely new insights into the development of these serious liver diseases. Building on this knowledge, we now want to develop new, preventive and therapeutic strategies to combat these diseases." The initial studies are already under way in the preclinical model.

*Metabolic syndrome: a combination of obesity / abdominal adiposity, insulin resistance, raise levels of lipids in the blood and raised blood pressure.


Story Source:

The above story is based on materials provided by Helmholtz Zentrum München - German Research Center for Environmental Health. Note: Materials may be edited for content and length.


Journal Reference:

  1. Monika Julia Wolf, Arlind Adili, Kira Piotrowitz, Zeinab Abdullah, Yannick Boege, Kerstin Stemmer, Marc Ringelhan, Nicole Simonavicius, Michèle Egger, Dirk Wohlleber, Anna Lorentzen, Claudia Einer, Sabine Schulz, Thomas Clavel, Ulrike Protzer, Christoph Thiele, Hans Zischka, Holger Moch, Matthias Tschöp, Alexei V. Tumanov, Dirk Haller, Kristian Unger, Michael Karin, Manfred Kopf, Percy Knolle, Achim Weber, Mathias Heikenwalder. Metabolic Activation of Intrahepatic CD8 T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes. Cancer Cell, 2014; 26 (4): 549 DOI: 10.1016/j.ccell.2014.09.003

 
 

Helmholtz Zentrum München - German Research Center for Environmental Health. "Immune cells in liver drive fatty liver disease, liver cancer." ScienceDaily. ScienceDaily, 14 October 2014. <www.sciencedaily.com/releases/2014/10/141014152536.htm>.

Potential drug could ease impact of bacterial lung infections in cystic fibrosis patients, tests suggest

 

October 14, 2014

 

By screening over 2,000 approved drugs and natural products, scientists have shown that tannic acid may help ease the impact of bacterial lung infections in cystic fibrosis patients. Tests completed using experimentally modified frog oocytes show that tannic acid counteracts the harmful effect of an enzyme produced by the bacterium Staphylococcus aureus (S. aureus). However, more research is needed to find out if tannic acid can help treat S. aureus infections in humans.


By screening over 2,000 approved drugs and natural products, scientists have shown that tannic acid may help ease the impact of bacterial lung infections in cystic fibrosis patients. Tests completed using experimentally modified frog oocytes show that tannic acid counteracts the harmful effect of an enzyme produced by the bacterium Staphylococcus aureus (S. aureus). However, more research is needed to find out if tannic acid can help treat S. aureus infections in humans.

From an early age, the lungs of individuals with cystic fibrosis (CF) are colonised and infected by bacteria, a common example being S. aureus. These bacterial infections cause the lungs to become inflamed, infected, and can eventually lead to permanent lung damage. Researchers from the University of Pennsylvania and the Howard Hughes Medical Institute previously showed that an enzyme called Sphingomyelin phosphodiesterase C (SMaseC) produced by the S. aureus bacterium may harm the health of CF patients. Now, they have discovered an inhibitor for this pathogenic bacterial enzyme.

In patients suffering from CF, the cystic fibrosis "transmembrane conductance regulator" (CFTR) channels are faulty, causing a thick mucus to build up in their lungs. In these experiments, the authors used oocytes from the Xenopus type of frog -- that had been genetically modified to express CFTR channels on their cell surface -- to measure the effect that SMaseC has on CFTR channels. They saw that the SMaseC enzyme suppresses CFTR channel activity in these experimentally modified frog oocytes, and also in a human lung cell line.

These results suggest that the SMaseC enzyme, produced by the S. aureas bacterium, may reduce any residual channel activity in CF patients. The problems originating from genetic defects in CFTR channels are likely made greater if the enzyme reduces the function of the CFTR channel even further.

SMaseC also suppresses a type of voltage-gated potassium channel, known as the Kv1.3 channel, in immune cells. Suppression of these potassium channels is known to weaken host immunity, which would make it more difficult for the CF patients to recover from lung infections.

To try and counteract the effects of the enzyme, the researchers went on to test a collection of approved drugs and natural products in a chemical library. They found that tannic acid -- a readily available and inexpensive natural product that has been used to treat disease as far back as 1850 -- stopped SMaseC from having a negative effect on both the CFTR and the Kv1.3 channels. "We hope to test whether the application of the SMaseC inhibitor tannic acid, in conjunction with effective antibiotic treatment and supportive measures, will provide a significant therapeutic improvement over current treatments for cystic fibrosis," Dr. Zhe Lu, the senior author, says. His team is also working hard to understand the exact mechanism by which tannic acid counters the negative actions of SMaseC.


Story Source:

The above story is based on materials provided by eLife. Note: Materials may be edited for content and length.


Journal Reference:

  1. Yajamana Ramu, Yanping Xu, Hyeon-Gyu Shin, Zhe Lu. Counteracting suppression of CFTR and voltage-gated K channels by a bacterial pathogenic factor with the natural product tannic acid. eLife, 2014; 3 DOI: 10.7554/eLife.03683

eLife. "Potential drug could ease impact of bacterial lung infections in cystic fibrosis patients, tests suggest." ScienceDaily. ScienceDaily, 14 October 2014. <www.sciencedaily.com/releases/2014/10/141014152538.htm>.

 

New information about how neurons act could lead to brain disorder advancements

 

October 14, 2014

University of Missouri-Columbia

Neurons are electrically charged cells, located in the nervous system, that interpret and transmit information using electrical and chemical signals. Now, researchers have determined that individual neurons can react differently to electrical signals at the molecular level and in different ways -- even among neurons of the same type. This variability may be important in discovering underlying problems associated with brain disorders and neural diseases such as epilepsy.


Schulz’ study was conducted on clusters of neurons found in Jonah crabs.

Neurons are electrically charged cells, located in the nervous system, that interpret and transmit information using electrical and chemical signals. Now, researchers at the University of Missouri have determined that individual neurons can react differently to electrical signals at the molecular level and in different ways -- even among neurons of the same type. This variability may be important in discovering underlying problems associated with brain disorders and neural diseases such as epilepsy.

"Genetic mutations found in neurological disorders create imbalances in the inward and outward flow of electrical current through cells," said David Schulz, associate professor in the Division of Biological Sciences in the College of Arts and Science and a researcher in the Interdisciplinary Neuroscience Program at MU. "Often, neurons react to electrical signals, or voltage, and compensate by altering their own electrical outputs. The variability in these imbalances, even among multiple cells of the same kind within the brain, is one of the major problems scientists face when trying to design therapeutics for disorders like epilepsy. Seizures in individuals can be caused by different imbalances -- therefore getting to the root of how neurons act individually makes our studies important."

Schulz and his team previously proved that two identical neurons can reach the same electrical activity in different ways. In his new study, Schulz hypothesized that neurons might use the cell's genetic code, or its messenger RNA (mRNA), to "fine tune" the production of proteins, helping individual cells react accordingly.

Using clusters of neurons obtained from Jonah crabs, Schulz and his team experimentally altered electrical input and output in the neurons and measured the messenger RNA (mRNA) levels found within the cells. Invertebrates like crabs are useful in neuroscience research because their neurons are simple enough to observe and study, but advanced enough that they can be "scaled up" to apply to higher organisms, Schulz said.

They found that when normal patterns of stimulation were maintained, cells engaged the correct ratios of mRNA to produce the proteins needed to help keep electrical impulses in order; however, when normal patterns of activity were not maintained, this fundamentally changed the cells at the molecular level.

"We were the first to show that the correct ratios of mRNAs are actively maintained by the actual activity or voltage of the cell, and not chemical feedback," Schulz said. "These results represent a novel aspect of regulation that might be useful for developing therapeutics for neuronal disorders later."

Schulz' study, "Activity-dependent feedback regulates correlated ion channel mRNA levels in single identified motor neurons," was published in the August 18th edition of Current Biology.


Story Source:

The above story is based on materials provided by University of Missouri-Columbia. Note: Materials may be edited for content and length.


Journal Reference:

  1. Simone Temporal, Kawasi M. Lett, David J. Schulz. Activity-Dependent Feedback Regulates Correlated Ion Channel mRNA Levels in Single Identified Motor Neurons. Current Biology, 2014; 24 (16): 1899 DOI: 10.1016/j.cub.2014.06.067

University of Missouri-Columbia. "New information about how neurons act could lead to brain disorder advancements." ScienceDaily. ScienceDaily, 14 October 2014. <www.sciencedaily.com/releases/2014/10/141014152645.htm>.