domingo, 21 de dezembro de 2014

Televised medical talk shows: Health education or entertainment?

 

"The research supporting any of these recommendations is frequently absent, contradictory or of poor quality," says Christina Korownyk, an associate professor in the Department of Family Medicine in the University of Alberta's Faculty of Medicine & Dentistry.

"The public may see these shows as educational," adds Mike Allan, a colleague and fellow professor in the Department of Family Medicine. "But in many ways we wonder if that's really what they're there for and perhaps they're just there for entertainment."

Korownyk and Allan are two of the authors of a new study published in the Christmas edition of the British Medical Journal, which examines the recommendations of televised medical talk shows. The researchers say they settled on the study after hearing concerns from several physicians whose patients took to heart the advice given on the shows.

"Some patients come in and say 'I heard on Dr. Oz yesterday that we should all be doing this.' And then we're left scrambling in our office to try to find answers," says Korownyk. "It got us reflecting, what's being said there? What kinds of things are being recommended and what kind of information is being provided?"

To find an answer, the team chose two internationally syndicated medical talk shows to analyze: The Dr. Oz Show and The Doctors. Each show was recorded every day from January 2013 to April 2013. From there, the researchers randomly selected 40 episodes of each show and had two team members watch every episode independently, recording topics, recommendations made and who was making the recommendations. After that, another two researchers were brought in to re-watch the episodes, focusing on the information provided in the recommendations and answering the questions: was there a benefit mentioned? Was it specific? Did the show quantify the magnitude of the benefit? Did they mention costs? Did they mention conflict of interest?

The team then randomly selected 80 of the strongest recommendations from each show for further study, giving the medical researchers an hour per question to try and find out if there was any evidence to support what was being said. Korownyk says the results were revealing.

"One out of three recommendations from The Dr. Oz Show has believable evidence and about half of the recommendations on The Doctors has believable evidence."

"Frequently you're not getting enough information and without doing the research you won't know if it's supported by evidence or not," adds Allan.

Among the other findings:

Most common topic discussed after general medical advice:

  • The Dr. Oz Show -- Dietary advice (43.2 percent)
  • The Doctors -- Dietary advice (16.8 percent)

Most common recommendations given:

  • The Dr. Oz Show -- Dietary advice (39.2 percent)
  • The Doctors -- Consult a health-care professional (17.8 percent)

Were specific benefits mentioned along with the recommendation?

  • The Dr. Oz Show -- (42.6 percent)
  • The Doctors -- (41.3 percent)

Was the magnitude of the benefit mentioned with the recommendation?

  • The Dr. Oz Show -- (16.5 percent)
  • The Doctors -- (11 percent)

Were possible harms mentioned?

  • The Dr. Oz Show -- (9.8 percent)
  • The Doctors -- (7.6 percent)

Were costs mentioned?

  • The Dr. Oz Show -- (12.5 percent)
  • The Doctors -- (3.1 percent)

Korownyk and Allan also note that out of 924 total recommendations examined, in only four instances were there accompanying mentions of potential conflict of interest by the presenter. Allan believes the sum of evidence shows viewers aren't being given enough information to make the best decisions.

"It is limited and would not allow many patients to make a clear informed choice about what they're hearing. They're really taking these recommendations based on their trust of the host rather than making an informed choice based on the information provided."

The researchers say it appears that general advice for the public is often not the best path for viewers to make their health decisions. And while televised medical talk shows may be great entertainment, listening to health-care providers who can give specific and balanced advice will leave people healthier and happier in the long run.

"Our bottom line conclusion is to be skeptical of what you hear on these shows," says Allan.

Marine conservation biologist Julia K. Parrish / ScienceLives

 

As a scuba diver and a marine conservation biologist, Julia K. Parrish frequently dives into her work with wild abandon--literally. But as the executive director of a citizen science group that organizes volunteers to monitor beach-cast seabird carcasses, Parrish even more frequently keeps both feet firmly planted on the ground--or to be more specific: on the coastline. Parrish's Seattle-based citizen science group--the Coastal Observation and Seabird Survey Team (COASST)--is devoted to advancing the science of coastal ecology and contributing to natural resources management.

Science Now–Episode 29

 

Science Now Episode 29 In this episode we discover a new genetic toolkit for achieving increased plant production. We explore what our brain is doing when we read. We discover ways of making a more reliable prosthesis--and finally we learn how researchers are working to better forecast the size of future earthquakes and tsunamis.

110 Predictions For the Next 110 Years

 

 

It's never easy to predict the future. But as PM's 110th anniversary celebration draws to a close, we've decided to try. Here are 110 ambitious ideas for the decades ahead.

2012—2022

· People will be fluent in every language. With DARPA and Google racing to perfect instant translation, it won't be long until your cellphone speaks Swahili on your behalf.
· Software will predict traffic jams before they occur. Using archived data, roadside sensors, and GPS, IBM has come up with a modeling program that anticipates bumper-to-bumper congestion a full hour before it begins. Better yet, the idea proved successful in early tests—even on the Jersey Turnpike.
· Climate-controlled jackets will protect soldiers from extreme heat and cold. The secret to all-weather clothing, according to former MIT student Kranthi Vistakula, is
Peltier plates, which can be used to warm you up or cool you down by sending an electric current across the junction between two different metals. U.S. soldiers have put the lightweight tech to the test. So have soldiers in India. Based on early reviews, it won't be long until others enlist.
· Nanoparticles will make chemotherapy far more effective. By delivering tiny doses of cisplatin and docetaxel right to cancerous cells,
the mini messengers will significantly reduce the pain and side effects of today's treatments.
· Electric cars will roam (some) highways. Who says you can't
road-trip in a Tesla? In a few years, the 1350-mile stretch of Interstate 5 spanning Washington, Oregon, and California will be lined with fast-charging stations—each no more than 60 miles apart. In some areas you will find stations to the east and west too. Don't get any bright ideas, though. If you try to cross the country, you won't get much farther than Tucson.
· Athletes will employ robotic trainers. Picture a rotor-propelled drone that tracks a pattern on your T-shirt with an onboard camera. Now imagine it flying in front of you at world-record pace. That's just the start—a simple concept developed by researchers in Australia.
· Bridges will repair themselves with self-healing concrete. Invented by University of Michigan engineer Victor Li, the new composite is laced with microfibers that bend without breaking. Hairline fractures mend themselves within days when calcium ions in the mix react with rainwater and carbon dioxide to create a calcium carbonate patch.
· Digital "ants" will protect the U.S. power grid from cyber attacks.   Programmed to wander networks in search of threats, the high-tech sleuths in this software, developed by Wake Forest University security expert Errin Fulp, leave behind a digital trail modeled after the scent streams of their real-life cousins. When a digital ant designed to perform a task spots a problem, others rush to the location to do their own analysis. If operators see a swarm, they know there's trouble.
· Scrolls will replace tablets. Researchers have already reproduced words and images on thin plastic digital displays. If they want those displays to compete with the iPad, they need to fine-tune the color and refine the screens so you can put your feet up and watch LeBron throw down on YouTube.
Your Car Will Be Truly Connected
· It will communicate with traffic lights to improve traffic flow.
· It will interact with other vehicles to prevent accidents.
· It will let you drag and drop a playlist from your home network.
· It will find the gas station with the deepest discount and handle the payment.
· It will notify you when someone dents your door and supply footage of the incident.
As we branch out as a species, it's quite reasonable to think that we'll send 3D printers to other planets to print habitats for humans prior to our arrival. — Dave Evans, Chief Technology Officer and Resident Futurist, Cisco Systems
· Your genome will be sequenced before you are born. Researchers led by Jay Shendure of the University of Washington recently reconstructed the genome of a fetus using saliva from the father and a blood sample from the mother (which yielded free-floating DNA from the child). Blood from the umbilical cord later confirmed that the sequencing was 98 percent accurate. Once the price declines, this procedure will allow us to do noninvasive prenatal testing.
· Radiation sickness will be cured by injection. Thanks to interest from the Department of Defense, several treatment options are now vying for FDA approval. In clinical trials, one of them, Ex-Rad, has not only prevented long-term cell damage but also promoted bone marrow recovery.
· That car part you need
will be sculpted inside a 3D printer. Dentists are already using this modern tech wonder to transform laser scans of your mouth into custom-fit appliances for your teeth. But that's a fraction of what the machine can do. When a 3D printer costs the same as, say, an HDTV, you will use one of your own to download all sorts of useful things, marveling as it creates each item layer by layer from plastic, rubber, titanium—you name it. Just imagine your future self printing a birthday cake, a Rolex, or a catalytic converter for the car. In time you'll even be able to download prescription medicine.
· Drugs will be tested on "organ chips" that mimic the human body. Now undergoing trials in 15 research institutions, the new silicon chips feature channels that house living kidney or lung cells, above. Simulated blood and oxygen flow allows them to mirror the actions of real organs, reducing the need for animal testing and speeding up drug development—in the midst of a pandemic, that would be crucial.
·
Passwords will be obsolete. IBM says it will happen in five years. Who are we to disagree? Apple and Google are designing face-recognition software for cellphones. DARPA is researching the dynamics of keystrokes. Others are looking into retinal scans, voiceprints, and heartbeats. The big question, it seems, is what will you do with all that time you used to spend dreaming up new ways to say JZRulz24/7!
· Car tires will be brewed by bacteria.    Isoprene—a key ingredient in rubber—is produced naturally by many plants but not at great enough volume to keep pace with the world's demand for tires. It can also be extracted from oil. But biotech firm Genencor has engineered E. coli microbes that produce gobs of the stuff as a by-product of metabolizing plant sugars. Goodyear, a partner in the study, is already testing prototypes of these bio-isoprene tires.
· Self-cleaning buildings will help us fight smog.    When sunlight strikes their aluminum skin, a titanium dioxide coating releases free radicals, which break down the grime and convert toxic nitrogen oxide molecules in the air into a harmless nitrate. Everything washes away in the rain.
· Your clothes will clean themselves too. Engineers in China have developed a titanium dioxide coating that helps cotton shed stains and eliminate odor-producing bacteria. To revive your lucky shirt after a night of poker, you need only step into the sun.
· Drones will protect endangered species.    Guarding at-risk animals from poachers with foot patrols is expensive and dangerous. This summer rangers in Nepal's Chitwan National Park previewed a savvy solution: Hand-launched drones armed with cameras and GPS provided aerial surveillance of threatened Indian rhinos.
· Data will be measured in zettabytes.   According to the International Data Corporation, the volume of digital content created on the planet in 2010 exceeded a zettabyte for the first time in history. By the end of this year, the annual figure will have reached 2.7 zettabytes. What exactly does a zettabyte look like? Well, if each byte were a grain of sand, the sum total would allow you to build 400 Hoover Dams.
· Rescuers will use electronic noses to locate disaster victims.   Some devices will use an array of sensors to rapidly detect carbon dioxide, ammonia, and acetone released into the rubble via breath, sweat, and skin. Others sniff out chemical compounds from human remains buried 3 feet underground. All keep working long after the dogs have retired to their kennels.
· Genetic testing will be used to halt epidemics.    A year ago, investigators at the National Human Genome Research Institute teamed with doctors in Maryland to track the outbreak of a deadly bacterial infection. The big breakthrough? Real-time genome sequencing, which helped them identify minute mutations in the microbe, determine how it spread, and quickly stop it.
· Vaccines will wipe out drug addiction.   The human immune system is supremely adept at detecting and neutralizing foreign substances. Why not train it to target illicit ones? That's the idea behind addiction vaccines: Persuade the body to produce antibodies that shut down drug molecules before they get to the brain. The concept works in mice. Human trials are under way.
·
Smart homes will itemize electric, water, and gas bills by fixture and appliance.    Shwetak Patel, a 30-year-old MacArthur Fellow, is working on low-cost sensors that monitor electrical variations in power lines to detect each appliance's signature. He has already used pressure changes to do the same for gas lines and water pipes. It's up to you to pinpoint where the savings lie.
· Vegetarians and carnivores will dine together on synthetic meats.    We're not talking about tofu. We're talking about nutritious, low-cost substitutes that look and taste just like the real thing. Twitter co-founder Biz Stone has already invested in Beyond Meat, which makes plant-based chicken strips so convincing they almost fooled New York Times food writer Mark Bittman.

2023—2062
· Contact lenses will grant us Terminator vision.     When miniaturization reaches its full potential, achieving superhuman eyesight will be as simple as placing a soft lens on your eye. Early prototypes feature wirelessly powered LEDs. But circuits and antennas can also be grafted onto flexible polymer, enabling zooming, night vision, and visible data fields.
· Checkups will be conducted by cellphone.    The technology is no problem. Scientists are hard at work
trying to perfect apps that can measure your heart and respiration rates, perform blood and saliva tests—even evaluate your cough. Question is how long will it take the medical industry to embrace them.
· All 130 million books on the planet will be digitized.   In 2010 Google planned to complete the job by decade's end, but as of March it still had 110 million tomes to go, so we're adding wiggle room. You might use the time to shop for storage, because given today's options and the average size of an e-book (3 MB), you'll need 124 3-terabyte drives to carry the library of humanity with you. It won't fit into a backpack, but it's small enough to schlep in a hockey bag.
· Nurse Jackie will be a robot. By 2045, when seniors (60-plus) outnumber the planet's youth (15 and under) for the first time in history, hospitals will use robots to solve chronic staffing issues. Expect to find the new Nightingales lifting patients and pushing food carts. Engineers at Purdue University are thinking even bolder—designing mechanical scrub nurses that respond to hand gestures during surgery.
· Supersonic jets will return—for good this time.      The limit on
supersonic flight is not one of engineering but of economics. Aircraft that break the speed of sound guzzle fuel, so new jet engines will have to be efficient. One solution—the pulse detonation engine, which uses a fuel—air mixture—was tested at the Mojave Air & Space Port in 2008. By 2030 a successor will power that fabled 2-hour hop from New York to London.
Your Car WIll Be Truly Connected
· The refrigerator will place your grocery order.
· The carpet will detect intruders and summon help if you fall.
· Lawn sensors will tell you which part of your yard to fertilize.
· The electric meter will monitor local power consumption and help you make full use of off-peak rates.
· The thermostat will learn your preferences and adjust the climate in each room as soon as you enter.
Within 30 years humans will begin augmenting their brains by plugging the power of tomorrow's cellphones directly into their heads. — Shawn Carlson, founder of the Society for Amateur Scientists
· Highways will handle three times as many cars.   According to researchers at Columbia University, vehicles driven by humans use at best 5 percent of a highway's road surface at any given time. If we let technology take the wheel, we could significantly increase the volume of traffic. In one example, Volvo's semiautonomous road train wirelessly connects a stream of cars to a truck driven by a professional. The self-driving cars mimic the speed and steering of the lead vehicle, safely decreasing the gaps while increasing fuel efficiency.
· Farmers will grow caffeine-free coffee beans.   Taking caffeine out of coffee is no easy chemical feat, which is why decaf lacks the rich flavor of the high-test stuff. After years of research, Brazilian scientists have discovered a mutant strain of coffee that's naturally low in caffeine. They won't rest until they learn how to remove every last drop of the sleep-retarding stimulant.
·
Supercomputers will be the size of sugar cubes.    The trick is to redesign the computer chip. Instead of the standard side-by-side model in use today, IBM researchers believe they can stack and link tomorrow's chips via droplets of nanoparticle-infused liquid. This would eliminate wires and draw away heat. What it won't do is help you remember where you left your tiny computer before you went to bed.
We will find life beyond Earth.   There's a horse race going on right now, and one of those horses is going to cross the finish line in the next two decades. — Seth Shostak, senior astronomer, SETI
· A virtual lawyer will help you plan your estate.   "I don't mean avatars," Cisco's Dave Evans says. "I mean virtual people—self-contained, thinking organisms indistinguishable from humans." Sounds crazy, right? But surely you've seen the magic of CGI. What's to say you can't attach a lifelike visage to an interface fronting the crowdsourced wisdom of the Internet? Give it a nice head of hair, teach it how to smile, and you're looking at a brilliant legal eagle with awesome people skills.
· Vertical farms will feed cities.    There will be 9 billion people on the planet in 2050, seven out of 10 of them in urban areas, and everyone's got to eat.
Future food production will depend on farmscrapers that grow pesticide-free crops year-round—making it much simpler to eat local.
· Connecticut will feed the world.   To keep up with all the hungry mouths, we may just have to rethink food. The folks at tech startup Pronutria claim to have discovered an industrious single-cell organism that converts sunlight, CO2 and water into low-cost nutrients. It works in tight quarters too. Instead of a few thousand pounds of crops per acre a year, we'd be looking at 100,000, according to the company's research. In other words, the planet's protein could be produced in an area half the size of Connecticut.
· Scientists will discover direct evidence of dark matter.   It may account for 23 percent of the mass in the universe, yet we haven't confirmed that dark matter exists. Why? "It's like a hidden magnet," says Dr. Fred Calef of the Mars Science Laboratory. "You can see what it pulls but can't see the source." Theoretical physicist Michio Kaku believes the proof we seek could arrive within 15 years, helping us to unlock the origins of our universe, and maybe even open the door to another one.
·
Navy SEALs will be able to hold their breath for 4 hours.   Advances in nanotechnology will help us overcome not only illness but also the limits of being human. For example, robotic red blood cells called respirocytes could each hold 200 times the oxygen of their natural counterparts, enabling a man on a mission to, say, hide out underwater for half a day without a scuba tank.
· Tuna will be raised on farms.    Ah, the bluefin—powerful, dangerous, graceful ... and delicious served raw. Long reproduction cycles and a migratory lifestyle make it hard to tame, though. Pioneering fish farms in Mexico are now raising the species, fattening tons of fish in massive underwater pens. Similar efforts are underway in the U.S., Japan, and the Mediterranean.

2063—2122
· Robots will rule the LV games!   China started hosting the International Humanoid Robot Olympic Games in 2010, and inventor Dean Kamen is pushing for high-tech competitors in Rio de Janeiro in the summer of 2016. "The original Olympic skill sets were javelin throws, wrestling, and fighting skills that countries needed for defense," he says. "In the 21st century, sports should require modern skills like programming and mechanical prowess." We say let's get started. By 2100 we hope to design the android version of Michael Phelps.
· The Pentagon will say goodbye to large submarines.   With the steady improvement in sonar technology, our subs are already hard-pressed to evade detection. In the future, underwater robots with laser radar or other nonacoustic sensors will make the seas virtually transparent. So how will we deploy our nukes? Hypersonic missiles launched from our own shores will reach any target in the world within 1 hour.
We're all gonna die. — MythBusters host Jamie Hyneman
· An
ion engine will reach the stars.   If you're thinking of making the trip to Alpha Centauri, pack plenty of snacks. At 25.8 trillion miles, the voyage requires more than four years of travel at light speed, and you won't be going nearly that fast. To complete the journey, you'll have to rely on a scaled-up version of the engine on the Deep Space 1 probe, launched in 1998. Instead of liquid or solid fuel, the craft was propelled by ions of xenon gas accelerated by an electric field.
Your Body Will Be Truly Connected
· Doctors will check your vital signs around the clock via tiny sensors.
· Stomach chips will monitor your diet to help you lose weight.
· Spinal cord implants will reverse paralysis.
· Brain chips will let you absorb data while you sleep.
· Brain interfaces will help you fully inhabit virtual worlds.
· Scientists will map the quadrillion connections between the brain's neurons.   Quadrillion sounds like a made-up number, but we assure you it's real. Those connections hold the answers to questions about mental illness, learning, and the whole nature versus nurture issue. If every one of them were a penny, you could stack them and build a tower 963 million miles high. It would stretch past Mars, Jupiter, and Saturn and stop roughly halfway to Uranus.
· One of us will celebrate a 150th birthday.   Our money's on Keith Richards. Given recent advances in health, technology, and medicine and the rise of genome science, it's only a matter of time until someone gets to blow out all those candles—especially if you toss in a breakthrough on the scale of antibiotics, says David Ewing Duncan, author of When I'm 164. What are your odds of living to see our predictions come true? There are more than 300,000 centenarians on the globe already—and one hearty soul has reached the age of 122.
THE PM BRAIN TRUST SAYS:
WITHIN 20 YEARS...
Self-driving cars will hit the mainstream market.
Battles will be waged without direct human participation (think robots or unmanned aerial vehicles).
The first fully functional brain-controlled bionic limb will arrive.
WITHIN 30 YEARS...
All-purpose robots
will help us with household chores.
Space travel will become as affordable as a round-the-world plane ticket.
Soldiers will use exoskeletons to enhance battlefield performance.
WITHIN 40 YEARS...
Nanobots will perform medical procedures inside our bodies.
WITHIN 50 YEARS...
We will have a colony on Mars.
Doctors will successfully transplant a lab-grown human heart.
We will fly the friendly skies without pilots onboard.
And renewable energy sources will surpass fossil fuels in electricity generation.
WITHIN 60 YEARS...
Digital data (texts, songs, etc.) will be zapped directly into our brains.
We will activate the first fusion power plant.
And we will wage the first battle in space.
WITHIN 100 YEARS...
The last gasoline-powered car will come off the assembly line.


sid_melo blogreen will reach the mark of 1 million posts

Cuba’s Internet Revolution

 

Easy access to the Internet is an important tool in economic and political development.

Cubans could be about to enjoy vastly improved access to communications technology under proposed normalization of relations with the United States, which will permit companies to import telecom infrastructure and expertise. But economic and political obstacles still need to be overcome for cheap, open Internet access to become a reality.

While the White House wants to remove trade restrictions on sending telecom gear and other technology to the country, it’s not yet clear what the regime of Raúl Castro, which strictly controls Internet access, will do.

“Castro has not committed to anything other than the prisoner swap and allowing a U.S. embassy on the island,” says Coco Fusco, visiting associate professor in the Comparative Media Studies/Writing program at MIT, who visits Cuba frequently and has done research on Cuba’s blogosphere. “No concrete promises have been made. We have to wait and see what the Cuban government actually decides to allow.”

Even basic Internet services could transform daily life in Cuba. Right now, only elites can easily get online. At government-sanctioned cyber-cafés, connecting to websites outside Cuba costs at least $5 an hour—a hefty price in a nation where the average monthly wage is $20. And in some cases users have been asked to sign agreements not to use their Web activities to do anything that might harm “public security.”

Those aren’t the only restrictions. If Cubans want to tweet, they must get around internal filters by using an international phone number—at a cost of about $1 per message, says Fusco. Plus, “the Cuban government has a monopoly on telecommunications service and can charge ridiculous rates for international and cell-phone service.”

The new policies could provide indirect technological help by making it easier for Cubans to afford things like mobile phones. The White House wants to authorize American credit card usage in Cuba, allow more tourism, and loosen policies on cash remittances, all of which could put more cash in people’s pockets.

“Common things like computers, mobile phones, and thumb drives are not easy to find in Cuba, and people want them,” says Ellery Roberts Biddle, editor of Global Voices Advocacy, who studies the politics of Internet use in Cuba (see “Cuba’s New Internet Service Is Also No Bed of Roses”). Having more money will be a huge help, she says: right now, Cubans often share information by passing around storage devices and plugging them into whatever old PCs they have access to.

Cuba’s electronic isolation can easily be seen in its fiber Internet connections. Whereas the Dominican Republic, nearby, has five fiber-optic cables landing on the coastline, Cuba has only one, financed by the Venezuelan government.

It’s an open question whether Cuba will build out public infrastructure and allow increased investment by U.S. and global technology companies and telecoms. “But if this does in fact occur, it will be interesting to see if they pursue a mobile-first model instead of investing in fiber deployment,” says David Belson, senior director of industry and data intelligence at Akamai, the Web-optimization company. Either way, such changes would require not just a relaxation of Cuban restrictions on Internet content, but also economic growth to support the new infrastructure and ensure that people have enough money to pay for service.

Even if Cuba’s dictatorship does pursue new communications technology, it might include means to help maintain control over the Internet, a strategy adopted by other repressive regimes. Several use American-made technology to filter and spy on their populations (see “Regimes Use U.S. Tech to Censor Citizens, Study Finds”).

For now, restrictions on communication technologies represent an “internal blockade,” says Ted Henken, a professor at Baruch College in New York City and author of a book about Cuban entrepreneurial policy. “Even as the external embargo crumbles, the internal embargo remains,” he says.

This Is How Music Can Change Your Brain

 

music class

Actively learning to play an instrument can help a child's academic achievement

Brain

Science has shown that when children learn to play music, their brains begin to hear and process sounds that they couldn’t otherwise hear. This helps them develop “neurophysiological distinction” between certain sounds that can aid in literacy, which can translate into improved academic results for kids.

Many parents probably read the above sentence and started mentally Google-ing child music classes in their local area. But if your kid doesn’t like learning an instrument or doesn’t actively engage in the class–opting to stare at the wall or doodle in a notebook instead of participating–he or she may not be getting all the benefits of those classes anyway.

A new study from Northwestern University revealed that in order to fully reap the cognitive benefits of a music class, kids can’t just sit there and let the sound of music wash over them. They have to be actively engaged in the music and participate in the class. “Even in a group of highly motivated students, small variations in music engagement — attendance and class participation — predicted the strength of neural processing after music training,” said Nina Kraus, director of Northwestern’s Auditory Neuroscience Laboratory  in an email to TIME. She co-authored the study with Jane Hornickel, Dana L. Strait, Jessica Slater and Elaine Thompson of Northwestern University.

Additionally, the study showed that students who played instruments in class had more improved neural processing than the children who attended the music appreciation group. “We like to say that ‘making music matters,'” said Kraus. “Because it is only through the active generation and manipulation of sound that music can rewire the brain.”

Kraus, whose research appeared today in Frontiers in Psychology, continued: “Our results support the importance of active experience and meaningful engagement with sound to stimulate changes in the brain.” Active participation and meaningful engagement translate into children being highly involved in their musical training–these are the kids who had good attendance, who paid close attention in class, “and were the most on-task during their lesson,” said Kraus.

To find these results, Kraus’s team went straight to the source, hooking up strategically placed electrode wires on the students’ heads to capture the brain’s responses.

Kraus’s team at Northwestern has teamed up with The Harmony Project, a community music program serving low-income children in Los Angeles, after Harmony’s founder approached Kraus to provide scientific evidence behind the program’s success with students.

According to The Harmony Project’s website, since 2008, 93 percent of Harmony Project seniors have gone on to college, despite a dropout rate of 50 percent or more in their neighborhoods. It’s a pretty impressive achievement and the Northwestern team designed a study to explore those striking numbers. That research, published in September in the Journal of Neuroscience, showed direct evidence that music training has a biological effect on children’s developing nervous systems.

As a follow up, the team decided to test whether the level of engagement in that music training actually matters. Turns out, it really does. Researchers found that after two years, children who not only regularly attended music classes, but also actively participated in the class, showed larger improvements in how the brain processes speech and reading scores than their less-involved peers.

“It turns out that playing a musical instrument is important,” Kraus said, differentiating her group’s findings from the now- debunked myth that just listening to certain types of music improves intelligence, the so-called “Mozart effect.” “We don’t see these kinds of biological changes in people who are just listening to music, who are not playing an instrument,” said Kraus. “I like to give the analogy that you’re not going to become physically fit just by watching sports.” It’s important to engage with the sound in order to reap the benefits and see changes in the central nervous system.

As to how to keep children interested in playing instruments, that’s up to the parents. “I think parents should follow their intuitions with respect to keeping their children engaged,” said Kraus. “Find the kind of music they love, good teachers, an instrument they’ll like. Making music should be something that children enjoy and will want to keep doing for many years!”

With that in mind, it’s not too late to trade in those Minecraft Legos, Frozen paraphernalia, XBox games, and GoldieBlox presents that you may have purchased, and swap them out for music lessons for the kids in your life.

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Atom-thick CCD could capture images

 

 

Rice University researchers fabricated a three-pixel, CIS-based optoelectronic sensor array to test the two-dimensional compound’s ability to capture image information. They started with few-layer exfoliated CIS on a silicon substrate, fabricated three pairs of titanium/gold electrodes on top of the CIS and cut the CIS into three sections with a focused ion beam.

An atomically thin material developed at Rice University may lead to the thinnest-ever imaging platform.

Synthetic two-dimensional materials based on metal chalcogenide compounds could be the basis for superthin devices, according to Rice researchers. One such material, molybdenum disulfide, is being widely studied for its light-detecting properties, but copper indium selenide (CIS) also shows extraordinary promise.

Sidong Lei, a graduate student in the Rice lab of materials scientist Pulickel Ajayan, synthesized CIS, a single-layer matrix of copper, indium and selenium atoms. Lei also built a prototype -- a three-pixel, charge-coupled device (CCD) -- to prove the material's ability to capture an image.

The details appear this month in the American Chemical Society journal Nano Letters.

Lei said the optoelectronic memory material could be an important component in two-dimensional electronics that capture images. "Traditional CCDs are thick and rigid, and it would not make sense to combine them with 2-D elements," he said. "CIS-based CCDs would be ultrathin, transparent and flexible, and are the missing piece for things like 2-D imaging devices."

The device traps electrons formed when light hits the material and holds them until released for storage, Lei said.

CIS pixels are highly sensitive to light because the trapped electrons dissipate so slowly, said Robert Vajtai, a senior faculty fellow in Rice's Department of Materials Science and NanoEngineering. "There are many two-dimensional materials that can sense light, but none are as efficient as this material," he said. "This material is 10 times more efficient than the best we've seen before."

Because the material is transparent, a CIS-based scanner might use light from one side to illuminate the image on the other for capture. For medical applications, Lei envisions CIS being combined with other 2-D electronics in tiny bio-imaging devices that monitor real-time conditions.

In the experiments for the newly reported study, Lei and colleagues grew synthetic CIS crystals, pulled single-layer sheets from the crystals and then tested the ability of the layers to capture light. He said the layer is about two nanometers thick and consists of a nine-atom-thick lattice. The material may also be grown via chemical vapor deposition to a size limited only by the size of the furnace, Lei said.

Because it's flexible, CIS could also be curved to match the focal surface of an imaging lens system. He said this would allow for the real-time correction of aberrations and significantly simplify the entire optical system.

Co-authors of the paper are Rice graduate students Fangfang Wen and Yongji Gong; postdoctoral researchers Bo Li, Pei Dong, Anthony George and Liehui Ge; undergraduates Qizhong Wang, James Bellah and Yihan Huang; complementary appointee Yongmin He of Lanzhou University, China; Jun Lou, an associate professor of materials science and nanoengineering, and Naomi Halas, the Stanley C. Moore Professor of Electrical and Computer Engineering and a professor of chemistry, biomedical engineering, physics and astronomy and of materials science and nanoengineering. Ajayan is Rice's Benjamin M. and Mary Greenwood Anderson Professor in Engineering, professor of materials science and nanoengineering and of chemistry and chair of the Department of Materials Science and NanoEngineering.

The research was supported by the Army Research Office Multidisciplinary University Research Initiative, the Function Accelerated nanoMaterial Engineering Division of the Semiconductor Technology Advanced Research Network, the Microelectronics Advanced Research Association, the Defense Advanced Research Projects Agency, the Netherlands Organization for Scientific Research, the Robert A. Welch Foundation, the National Security Science and Engineering Faculty Fellowship and the Office of Naval Research.

Story Source:

The above story is based on materials provided by Rice University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sidong Lei, Fangfang Wen, Bo Li, Qizhong Wang, Yihan Huang, Yongji Gong, Yongmin He, Pei Dong, James Bellah, Antony George, Liehui Ge, Jun Lou, Naomi J. Halas, Robert Vajtai, Pulickel M. Ajayan. Optoelectronic Memory Using Two-Dimensional Materials. Nano Letters, 2014; 141217153644008 DOI: 10.1021/nl503505f

Possible avenue to better electrolyte for lithium ion batteries

 

X-ray absorption spectra, interpreted using first-principles electronic structure calculations, provide insight into the solvation of the lithium ion in propylene carbonate.

The lithium-ion batteries that mobilize our electronic devices need to be improved if they are to power electric vehicles or store electrical energy for the grid. Berkeley Lab researchers looking for a better understanding of liquid electrolyte may have found a pathway forward. A team led by Richard Saykally, a chemist with Berkeley Lab's Chemical Sciences Division, David Prendergast, a theorist with Berkeley Lab's Molecular Foundry, and Steven Harris, a chemist with the Lab's Materials Sciences Division, found surprising results in the first X-ray absorption spectroscopy study of a model lithium electrolyte.

"A crucial process in lithium ion batteries is the transport of lithium ions between the electrodes," explains Saykally. "Commercial lithium-ion batteries contain a liquid electrolyte comprising a lithium salt dissolved in an alkyl carbonate solvent system. There's disagreement in the battery industry on the nature of the local solvation environment of lithium ions in these solutions, a critical issue because the desolvation of the ions as they move through the negative electrode is believed to limit the electrical power that can be made available."

Most previous computational simulations have predicted a tetrahedral solvation structure for the lithium ion in the electrolyte, but the new study by Saykally, Prendergast, Harris and their collaborators show this to not be the case.

"Our results indicate a solvation number of 4.5, which points to a non-tetrahedral solvation structure for the lithium ions," says lithium-battery expert Harris. "This contradicts numerous theoretical studies which indicated a primarily tetrahedral coordination structure with a solvation number near 2 or 3, depending on the prevalence of ion pairing. Based on our results, to design better performing electrolytes, future computational models will need to move beyond tetrahedral coordination structures."

Lithium-ion batteries (LIBs) make any short list of great inventions of the 20th century. Today LIBs represent a multibillion dollar industry as the power supply of cellular phones, tablets, laptops and other handheld electronic devices. However, serious shortcomings -- high costs, inadequate energy densities, long recharge times and short cycle-life times -- have hampered the use of LIBS for electric vehicles and for efficient electrical energy storage systems that can be used in conjunction with wind and solar energy sources.

Although it has become increasingly clear to the battery industry that improvements in the liquid electrolyte are essential if LIBs are to be effective for electric vehicles and large-scale energy storage, most LIB research has focused on the electrodes and solid electrolyte interphase. The problem has been a lack of capabilities for the requisite experiments, particularly X-ray spectroscopy.

This deficiency was addressed by Saykally and his group with their development of a unique liquid microjet technology in which two aqueous samples rapidly mix and flow through a finely tipped silica nozzle only a few micrometers in diameter. The resulting liquid beam travels a few centimeters in a vacuum chamber before it is intersected by an X-ray beam then collected and condensed out. This liquid microjet system has been set up at Beamline 8.0.1 of Berkeley Lab's Advanced Light Source (ALS). Beamline 8.0.1 is a high flux undulator beamline that produces X-ray beams optimized for X-ray spectroscopy.

"Working at the ALS with our liquid microjet system, we used X-ray absorption spectroscopy to study lithium tetrafluoroborate in propylene carbonate," Saykally says. "X-ray absorption spectroscopy is an atom-specific core-level spectroscopic probe of unoccupied electronic states. It is highly sensitive to both the intra- and intermolecular environment of the target atom."

The XAS experimental spectra were interpreted through molecular dynamics and density functional theory spectral simulations carried out on the supercomputers at the National Energy Research Scientific Computing Center (NERSC) by Prendergast and Jacob Smith, a graduate student in Saykally's research group. The ALS, the Molecular Foundry and NERSC are all DOE Office of Science national user facilities hosted at Berkeley Lab.

A paper describing this research has been published in the journal Physical Chemistry Chemical Physics. The paper is titled "X-Ray absorption spectroscopy of LiBF4 in propylene carbonate: a model lithium ion battery electrolyte." Saykally is the corresponding author, Smith the lead author. Other co-authors in addition to Harris and Prendergast were Royce Lam, Alex Sheardy, Orion Shih, Anthony Rizzuto and Oleg Borodin.

This research was supported by the DOE Office of Science.


Story Source:

The above story is based on materials provided by DOE/Lawrence Berkeley National Laboratory. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jacob W. Smith, Royce K. Lam, Alex T. Sheardy, Orion Shih, Anthony M. Rizzuto, Oleg Borodin, Stephen J. Harris, David Prendergast, Richard J. Saykally. X-Ray absorption spectroscopy of LiBF4in propylene carbonate: a model lithium ion battery electrolyte. Phys. Chem. Chem. Phys., 2014; 16 (43): 23568 DOI: 10.1039/c4cp03240c

 

Yellowstone's thermal springs: Their colors unveiled

 

This is a photograph of Morning Glory Pool from Aug. 23, 2012.

Researchers at Montana State University and Brandenburg University of Applied Sciences in Germany have created a simple mathematical model based on optical measurements that explains the stunning colors of Yellowstone National Park's hot springs and can visually recreate how they appeared years ago, before decades of tourists contaminated the pools with make-a-wish coins and other detritus.

The model, and stunning pictures of the springs, appear today in the journal Applied Optics, which is published by The Optical Society (OSA).

If Yellowstone National Park is a geothermal wonderland, Grand Prismatic Spring and its neighbors are the ebullient envoys, steaming in front of the camera and gracing the Internet with their ethereal beauty. While the basic physical phenomena that render these colorful delights have long been scientifically understood -- they arise because of a complicated interplay of underwater vents and lawns of bacteria -- no mathematical model existed that showed empirically how the physical and chemical variables of a pool relate to their optical factors and coalesce in the unique, stunning fashion that they do.

"What we were able to show is that you really don't have to get terribly complex -- you can explain some very beautiful things with relatively simple models," said Joseph Shaw, a professor at Montana State University and director of the university's Optical Technology Center. Shaw, along with his Ph.D. student Paul Nugent and German colleague Michael Vollmer, co-authored the new paper.

Using a relatively simple one-dimensional model for light propagation, the group was able to reproduce the brilliant colors and optical characteristics of Yellowstone National Park's hot springs by accounting for each pool's spectral reflection due to microbial mats, their optical absorption and scattering of water and the incident solar and diffuse skylight conditions present when measurements were taken.

"When we started the study, it was clear we were just doing it for fun," Vollmer said. But they quickly discovered there was very little in the scientific literature on the subject. That's when things got interesting.

Montana State University, in Bozeman, Mont., is a short drive away from Yellowstone National Park. In the summer of 2012, Vollmer, on sabbatical from the Brandenburg University of Applied Sciences, travelled with Shaw and Nugent to the park. Using handheld spectrometers, digital SLR cameras for visible images and long wave infrared thermal imaging cameras for non-contact measurement of the water temperatures, the group took measurements at a number of pools in Yellowstone, including Morning Glory Pool, Sapphire Pool and Grand Prismatic Spring. Using these data, along with previously available information about the physical dimensions of the pools, they were able to create a simple model whose renderings of the pools were strikingly similar to actual photographs.

In the case of Morning Glory Pool, they were even able to simulate what the pool once looked like between the 1880s and 1940s, when its temperatures were significantly higher. During this time, its waters appeared a uniform deep blue. An accumulation of coins, trash and rocks over the intervening decades has partially obscured the underwater vent, lowering the pool's overall temperature and shifting its appearance to a terrace of orange-yellow-green. This change from blue was demonstrated to result from the change in composition of the microbial mats, as a result of the lower water temperature.

A general relationship between shallow water temperature (hence microbial mat composition) and observed colors was confirmed in this study. However, color patterns observed in deeper segments of the pool are caused more by absorption and scattering of light in the water. These characteristics -- mats having greater effect on color in shallow water, and absorption and scattering winning out in the deeper areas -- are consistent across all the measured pools.

"Our paper describes a very simple, one-dimensional model, that gives the first clue if you really want to do more," Vollmer said.

"We didn't start this project as experts on thermal pools," Shaw said. "We started this project as experts on optical phenomena and imaging, and so we had a lot to learn."

"There are people at my university who are world experts in the biological side of what's going on in the pools," Shaw said. "They're looking for ways to monitor changes in the biology -- when the biology changes, that causes color changes -- so we're actually looking at possibilities of collaborating in the future."

Future work for Nugent, Vollmer and Shaw includes delving further into infrared imaging at Yellowstone National Park.

Story Source:

The above story is based on materials provided by American Institute of Physics (AIP). Note: Materials may be edited for content and length.


Journal Reference:

  1. Paul W. Nugent, Joseph A. Shaw, Michael Vollmer. Colors of thermal pools at Yellowstone National Park. Applied Optics, 2014; 54 (4): B128 DOI: 10.1364/AO.54.00B128

Breakthrough in optical fiber communications

 

December 19, 2014

University of Southampton

Researchers from the University of Southampton have revealed a breakthrough in optical fiber communications. They developed an approach that enables direct modulation of laser currents to be used to generate highly advanced modulation format signals. The research explores a radically new approach to the generation of spectrally-efficient advanced modulation format signals as required in modern optical communication systems.


This is a constellation diagram of one of the mainstream modulation formats of the future system: Sixteen Quadrature-Amplitude modulation.

Researchers from the University of Southampton have revealed a breakthrough in optical fibre communications. Academics from the University's Optoelectronics Research Centre (ORC) have collaborated with colleagues at Eblana Photonics Inc, in Ireland, to develop an approach that enables direct modulation of laser currents to be used to generate highly advanced modulation format signals.

The research, published in the journal Nature Communications, explores a radically new approach to the generation of spectrally-efficient advanced modulation format signals as required in modern optical communication systems.

This new technology, patented by the University of Southampton and licensed to Eblana Photonics Inc, avoids the need for costly and power-inefficient external modulator schemes that are currently used to generate such signals..

Dr Radan Slavik, Principal Research Fellow at the ORC, said: "Our paper highlights the exquisite control that we have achieved over the optical field generated directly from a current-modulated semiconductor laser."

Direct current modulated lasers are of huge commercial relevance and are already widely used in optical communications, telecommunications and sensor and high power fibre laser systems. However, the inability to accurately control the full optical field emitted directly from such lasers has been a fundamental problem limiting applications.

Dr Slavik explains: "The new capability we have demonstrated will be of relevance and could be of significant impact within many scientific and engineering communities that are directly concerned with or exploit laser radiation.

"We have previously presented some of the results included in this paper at conferences, including a post-deadline presentation at Optical Fibre Communications (OFC), and at an international symposium and this has already generated a lot of interest from senior academics in our community, as well as from leading industrial players."

Dr Rob Lennox, Director of Sales at Eblana Photonics Ltd., Dublin, said: "We are very pleased to have collaborated on this innovative development work performed by the ORC team and are looking towards making this new approach a commercial reality."


Story Source:

The above story is based on materials provided by University of Southampton. Note: Materials may be edited for content and length.


Journal Reference:

  1. Zhixin Liu, Joseph Kakande, Brian Kelly, John O’Carroll, Richard Phelan, David J. Richardson, Radan Slavík. Modulator-free quadrature amplitude modulation signal synthesis. Nature Communications, 2014; 5: 5911 DOI: 10.1038/ncomms6911

 

Helping parents understand infant sleep patterns

 

December 19, 2014

Penn State

Most parents are not surprised by the irregularity of a newborn infant's sleep patterns, but by six months or so many parents wonder if something is wrong with their baby or their sleeping arrangements if the baby is not sleeping through the night. Health-care providers, specifically nurse practitioners, can help parents understand what 'normal' sleep patterns are for their child, according to researchers.


Most parents are not surprised by the irregularity of a newborn infant's sleep patterns, but by six months or so many parents wonder if something is wrong with their baby or their sleeping arrangements if the baby is not sleeping through the night. Healthcare providers, specifically nurse practitioners, can help parents understand what "normal" sleep patterns are for their child, according to researchers.

"Nurse practitioners are at the frontline of healthcare," said Robin Yaure, senior instructor of human development and family studies, Penn State Mont Alto. "They are in an ideal position to help parents understand infant sleep pattern norms. Thus, nurse practitioners can help parents understand that 'sleeping through the night' is not entirely likely in young infants and that infants' sleep patterns change during the first few years of life."

According to the researchers, there are four common areas of concern for both parents and practitioners: what constitutes "normal" infant sleep and waking patterns, whether nightwakings are a problem or not, is a parent's presence disruptive when an infant is falling asleep, and whether sleep training is safe and healthy for infants. Sleep training is one way to establish a sleep routine for a child, although the methods used may not be appealing to parents or in the best interests of the child, the researchers said.

Yaure and colleagues reviewed current research on infant sleep, focusing on the above four areas of concern, and specifically infant safety and the well being of both infant and mother during nighttime care. The researchers suggest how to best integrate parents' preferences for care and best practice information, and include conversation points for nurse practitioners recently online in the Journal of the American Association of Nurse Practitioners.

Infants' sleep patterns vary for at least the first three years of life. There are many reasons for this, including changes in infant health and mobility and the development of separation anxiety.

"Sharing this basic information with parents is one way of assuring parents that infants' waking does not necessarily mean that the parents are doing something wrong," the researchers wrote.

Parent presence at bedtime, sleep training and infant self-settling are frequently debated topics about which parents might look to healthcare professionals for advice. Yaure and colleagues again point to sharing information with parents -- for example, recent research suggests that the presence of parents at bedtime, specifically during the transition to sleep, may not trigger nightwakings as previously thought.

The researchers also point out that recent research on the nonresponsiveness of mothers during nighttime care can raise stress for both mom and baby. Elevated stress increases cortisol in the body, which may hurt the baby in the long run. Increased cortisol levels are associated with depression, aggression and attention problems, among other issues, in children and adults.

"I worry about parents who feel like they can't trust their own instincts," said Yaure. "Different parents have different goals and ideas for parenting, and we want parents to figure out how to incorporate best practices into their belief system. We have to be culturally aware and sensitive to different families and beliefs."

By encouraging nurse practitioners to talk about current knowledge on infant nightwakings and parental presence, among other things, Yaure hopes that parents will become more comfortable and confident with their nighttime care choices.

Further research will include how doctors can also help translate research-based knowledge of infant sleep into practice.


Story Source:

The above story is based on materials provided by Penn State. The original article was written by Victoria M. Indivero. Note: Materials may be edited for content and length.


Journal Reference:

  1. Wendy Middlemiss, Robin Yaure, Erron L. Huey. Translating research-based knowledge about infant sleep into practice. Journal of the American Association of Nurse Practitioners, 2014; DOI: 10.1002/2327-6924.12159

 

Gene critical for proper brain development discovered

 

Scientists at A*STAR's Institute of Medical Biology (IMB) and Institute of Molecular and Cellular Biology (IMCB) have identified a genetic pathway that accounts for the extraordinary size of the human brain. The team led by Dr Bruno Reversade[1] from A*STAR in Singapore, together with collaborators from Harvard Medical School, have identified a gene, KATNB1, as an essential component in a genetic pathway responsible for central nervous system development in humans and other animals.

By sequencing the genome of individuals of normal height but with a very small head size, the international team revealed that these individuals had mutations in the KATNB1 gene, indicating that this gene is important for proper human brain development. Microcephaly (literally meaning "small head" in Latin) is a condition often associated with neurodevelopmental disorders. Measured at birth by calculating the baby's head circumference, a diagnosis of microcephaly is given if it is smaller than average.

Microcephaly may stem from a variety of conditions that cause abnormal growth of the brain during gestation or degenerative processes after birth, all resulting in a small head circumference. In general, individuals with microcephaly have a reduced life expectancy due to reduced brain function which is often associated with mental retardation.

The team also carried out further experiments to determine the function of KATNB1, whose exact mode of action was previously unknown in humans. Using organisms specifically designed to lack this gene, they realised that KATNB1 is crucial for the brain to reach its correct size. Zebrafish and mice embryos without this gene could not live past a certain stage and showed dramatic reduction in brain and head size, similar to the human patients. Their results were published in the 17 December 2014 online issue of Neuron.

Sequencing and screening for this particular gene before birth or at birth might also help to detect future neurocognitive problems in the general population. Dr Reversade said, "We will continue to search for other genes important for brain development as they may unlock some of the secrets explaining how we, humans, have evolved such cognitive abilities."

Prof Birgit Lane, Executive Director of IMB, said, "This is one of a small number of genes that scientists have found to be vital for brain development. The work is therefore an important advance in understanding the human brain. The team's findings provide a new platform from which to look further into whether -- and how -- this gene can be used for targeted therapeutic applications."

Prof Hong Wanjin, Executive Director of IMCB, said, "This coordinated effort shows the increasingly collaborative nature of science. As the complexity and interdisciplinary nature of research evolves, so do the networks of collaborations between research institutes at A*STAR and across continents."


Story Source:

The above story is based on materials provided by A*Star Agency for Science, Technology and Research. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ketu Mishra-Gorur, Ahmet Okay Çağlayan, Ashleigh E. Schaffer, Chiswili Chabu, Octavian Henegariu, Fernando Vonhoff, Gözde Tuğce Akgümüş, Sayoko Nishimura, Wenqi Han, Shu Tu, Burçin Baran, Hakan Gümüş, Cengiz Dilber, Maha S. Zaki, Heba A.A. Hossni, Jean-Baptiste Rivière, Hülya Kayserili, Emily G. Spencer, Rasim Ö. Rosti, Jana Schroth, Hüseyin Per, Caner Çağlar, Çağri Çağlar, Duygu Dölen, Jacob F. Baranoski, Sefer Kumandaş, Frank J. Minja, E. Zeynep Erson-Omay, Shrikant M. Mane, Richard P. Lifton, Tian Xu, Haig Keshishian, William B. Dobyns, Neil C. Chi, Nenad Šestan, Angeliki Louvi, Kaya Bilgüvar, Katsuhito Yasuno, Joseph G. Gleeson, Murat Günel. Mutations in KATNB1 Cause Complex Cerebral Malformations by Disrupting Asymmetrically Dividing Neural Progenitors. Neuron, 2014; 84 (6): 1226 DOI: 10.1016/j.neuron.2014.12.014