sexta-feira, 27 de junho de 2014

Delírio gauchesco

 

Um grupo de sulistas quer se separar do Brasil. Esse desejo embutido no coração de parte dos moradores da região nunca foi uma novidade. Mas, nos últimos anos, a mobilização pra viver livre do resto do país vem tomando corpo nas redes sociais.

O grupo "O Sul é o Meu País" reúne sulistas que desejam se separar do Brasil e viver sua vida em paz, sem a presença incômoda dos estados menos nobres da nação. Essa é a imagem de um país que dá certo:

Essa gente bonita faz questão de afirmar que faz um separatismo do bem, sem qualquer tipo de preconceito. Não tem nada contra o Brasil, nem com seu povo. Eles só querem viver em paz com seus bons modos forjados nos floridos campos europeus e se livrar "desse país atrasado", onde predomina o funk, o pagode, o axé e a pouca vergonha.

Veja como nossos "compatriotas" enxergam o país e o continente:

Assim como alguns paulistas chamam todos os nordestinos de "baiano", nossos separatistas do Sul chamam todo o nordeste de "Bahia", mostrando todo o seu respeito pela região. O norte e grande parte do centro-oeste são classificados como "Mato". No resto do continente, o único país que merece respeito é a Argentina, onde aparentemente as características europeias estão mais preservadas. Bolívia é tratada como "índios ladrões de gás", Paraguai é "muamba", Venezuela é "índios petroleiros" e o resto do continente é classificado genericamente como "índios".

Mas, claro, não se trata de preconceito com os povos não-brancos do continente. Nossos amigos apenas querem agregar valor ao seu bom gosto. Em enquete feita pra saber de quem será a torcida dos separatistas na Copa, uma massacrante maioria confessou estar torcendo contra o Brasil. A preferência dos membros do grupo varia entre Argentina, Uruguai, Holanda e Alemanha.

 Observação complementar:  O estado do Rio Grande do Sul faz parte intrínseca do território brasileiro desde o início.  Admiramos e respeitamos a tradição gaúcha, seu progresso, assim como admiramos e respeitamos as tradições culturais de outros estados como Minas Gerais, Bahia, Rio de Janeiro, e demais.  Mas eles tem que entender que não estamos mais na década de 30, onde São Paulo lutou práticamente sózinho. Hoje, somente a Grande São Paulo, capital, tem um PIB que é maior que dezenas de países, representa 70% do PIB da Argentina, é 4 vezes maior que o PIB da Coréia do Norte, é maior que o PIB de vários ESTADOS dos Estados Unidos, tomados isoladamente, representa 80% do PIB do seu estado (RS),  e por aí vai. (dados de 2011)  MAS NÃO NOS CONSIDERAMOS MAIS IMPORTANTES DO QUE OS OUTROS ESTADOS DA FEDERAÇÃO. QUALQUER UM DELES. 

Amigos gaúchos, gostamos muito de suas músicas, de suas danças, do seu sotaque, mas vocês são BRASILEIROS, e vão continuar sendo.  não se esqueçam disso. Se querem separar-se culturalmente, socialmente, e de outras formas, do restante do país, é um direito de vocês.  Mas não poderão separar-se políticamente, geográficamente. O “mato” a que vocês se referem na região Norte, é considerado o pulmão do mundo…..e dentro de algumas décadas será também economicamente muito importante, bem como a região Nordeste e Centro-Oeste.

Estão em 4º lugar em relação ao PIB dos estados brasileiros. Isso é muito importante, estão à frente de estados geográficamente bem maiores e políticamente importantes como Bahia, Goiás. Esqueçam esse patriotismo regional fora do contexto nacional, pátrio.

A História do Rio Grande do Sul é impressionante, mas estamos hoje em pleno século XXI e a realidade é bem outra.  Um abraço meus irmãos BRASILEIROS do Rio Grande do Sul.

 

 

As 100 melhores leis de Murphy

1.. Se alguma coisa pode dar errado, dará. E mais, dará errado da pior maneira, no pior momento e de modo que cause o maior dano possível.
2. Um atalho é sempre a distância mais longa entre dois pontos.
3. Nada é tão fácil quanto parece, nem tão difícil quanto a explicação do manual.
4. Tudo leva mais tempo do que todo o tempo que você tem disponível.
5. Se há possibilidade de várias coisas darem errado, todas darão - ou a que causar mais prejuízo.
6. Se você perceber que uma coisa pode dar errada de 4 maneiras e conseguir driblá-las, uma quinta surgirá do nada.
7. Seja qual for o resultado, haverá sempre alguém para:
a) interpretá-lo mal. b) falsificá-lo. c) dizer que já o tinha previsto em seu último relatório.
8. Quando um trabalho é mal feito, qualquer tentativa de melhorá-lo piora.
9. Acontecimentos infelizes sempre ocorrem em série.
10. Toda vez que se menciona alguma coisa: se é bom, acaba; se é ruim, acontece.
11. Em qualquer fórmula, as constantes (especialmente as registradas nos manuais de engenharia) deverão ser consideradas variáveis.
12. As peças que exigem maior manutenção ficarão no local mais inacessível do aparelho.
13. Se você tem alguma coisa há muito tempo, pode
jogar fora. Se você jogar fora alguma coisa que tem há muito tempo, vai precisar dela logo, logo.
14. Você sempre encontra aquilo que não está procurando.
15. Quando te ligam:
a) se você tem caneta, não tem papel.
b) se tem papel não tem caneta.
c) se tem ambos ninguém liga.
16. A Natureza está sempre à favor da falha.
17. Entre dois acontecimentos prováveis, sempre acontece um improvável.
18. Quase tudo é mais fácil de enfiar do que de tirar.
19. Mesmo o objeto mais inanimado tem movimento suficiente para ficar na sua frente e provocar uma canelada.
20. Qualquer esforço para se agarrar um objeto em queda provocará mais destruição do que se deixássemos o objeto cair naturalmente.
21. A única falta que o juiz de futebol apita com absoluta certeza é aquela em que ele está absolutamente errado.
22. Por mais bem feito que seja o seu trabalho, o patrão sempre achará onde criticá-lo.
23. Nenhum patrão mantém um
empregado que está certo o tempo todo.
24. Toda solução cria novos problemas.
25. Quando político fala em corrupção, os verbos são sempre usados no passado.
26. Você nunca vai pegar engarrafamento ou sinal fechado se saiu cedo demais para algum lugar.
27. Os assuntos mais simples são aqueles dos quais você não entende nada.
28. Dois monólogos não fazem um diálogo.
29. Se você é capaz de distinguir entre o bom e o mal conselho, então você não precisa de conselho.
30. Ninguém ficará batendo na sua porta, ou telefonando para você, se não houver trabalho algum a ser feito.
31. O trabalho mais chato é também o que menos paga.
32. Errar é humano. Perdoar não é a política da
empresa.
33. Toda a idéia revolucionária provoca três
estágios: 1º. é impossível - não perca meu tempo. 2º. é possível, mas não vale o esforço 3º. eu sempre disse que era uma boa idéia.
34. A informação que obriga a uma mudança radical no projeto sempre chega ao projetista depois do trabalho terminado, executado e funcionando maravilhosamente (também conhecida como síndrome do: "Porra! Mas só agora!!!").
35. Um homem com um relógio sabe a hora certa. Um homem com dois relógios sabe apenas a média.
36. Inteligência tem limite. Burrice não.
37. Seis fases de um projeto: Entusiasmo; Desilusão; Pânico; Busca dos culpados; Punição dos inocentes; Glória aos não participantes.
38. Conversas sérias, que são necessárias, só acontecem quando você está com pressa.
39. Não se dorme até que os filhos façam cinco anos.
40. Não se dorme depois que eles fazem quinze.
41. O orçamento
necessário é sempre o dobro do previsto. O tempo necessário é o triplo.
42. As variáveis variam menos que as constantes.
43. Pais que te amam não te deixam fazer nada. Pais liberais, não estão nem ai para você.
44. Entregas de caminhão que normalmente levam um dia levarão cinco quando você depender da entrega.
45. O único filho que ronca é o que quer dormir com você.
46. Assim que tiver esgotado todas as suas possibilidades e confessado seu fracasso, haverá uma solução simples e óbvia, claramente visível a qualquer outro idiota.
47. Qualquer programa quando começa a funcionar já está obsoleto.
48. Nenhuma bola vai parar em um vaso que você odeia.
49. Só quando um programa já está sendo usado há seis meses, é que se descobre um erro fundamental.
50. Crianças nunca ficam quietas para tirar fotos, e ficam absolutamente imóveis diante de uma câmera filmadora.
51. Nenhuma criança limpa quer colo.
52. A ferramenta quando cai no chão sempre rola para o canto mais inacessível do aposento. A caminho do canto, a ferramenta acerta primeiro o seu dedão.
53. Guia prático para a ciência moderna:
a) Se se mexe, pertence à biologia.
b) Se fede, pertence à química.
c) Se não funciona, pertence à física.
d) Se ninguém entende, é matemática.
e) Se não faz sentido, é psicologia.
54. O vírus que seu computador pegou, só ataca os arquivos que não tem cópia.
55. O número de exceções sempre ultrapassa o numero de regras. E há sempre exceções às exceções já estabelecidas.
56. Seja qual for o defeito do seu computador, ele vai desaparecer na frente de um técnico, retornando assim que ele se retirar.
57. Se ela está te dando mole, é feia. Se é bonita, está acompanhada. Se está sozinha, você está acompanhado.
58. Se o curso que você desejava fazer só tem n vagas, pode ter certeza de que você será o candidato n + 1 a tentar se matricular.
59. Oitenta por cento do exame final que você prestará, será baseado na única aula que você perdeu, baseada no único livro que você não leu.
60. Cada professor parte do pressuposto de que você não tem mais o que fazer, senão estudar a matéria dele.
61. A citação mais valiosa para a sua redação será aquela em que você não consegue lembrar o nome do autor.
62. Caras legais são feios. Caras bonitos não são legais. Caras bonitos e legais são gays.
63. A maioria dos trabalhos manuais exigem três mãos para serem executados.
64. As porcas que sobraram de um trabalho nunca se encaixam nos parafusos que também sobraram.
65. Quanto mais cuidadosamente você planejar um trabalho, maior será sua confusão mental quando algo der errado.
66. Tudo é possível. Apenas não muito provável.
67. Em qualquer circuito eletrônico, o componente de vida mais curta será instalado no lugar de mais difícil acesso.
68. Qualquer desenho de circuito eletrônico irá conter: uma peça obsoleta, duas impossíveis de encontrar, e três ainda sendo testadas.
69. O dia de hoje foi realmente necessário?
70. A luz no fim do túnel, é o trem vindo na sua direção.
71. A vida é uma droga. E você ainda reencarna.
72. Se está escrito "Tamanho Único", é porque não serve em ninguém.
73. Se o sapato serve, é feio!
74. Nunca há horas suficientes em um dia, mas sempre há muitos dias antes do sábado.
75. Todo corpo mergulhado numa banheira faz tocar o telefone.
76. A beleza está à flor da pele, mas a feiúra vai até o osso!
77. A informação mais necessária é sempre a menos disponível.
78. A probabilidade do pão cair com o lado da manteiga virado para baixo é proporcional ao valor do carpete.
79. Confiança é aquele sentimento que você tem antes de compreender a situação.
80. A fila do lado sempre anda mais rápido.
81. Nada é tão ruim que não possa piorar.
82. O material é danificado segundo a proporção direta do seu valor.
83. Se você está se sentindo bem, não se preocupe. Isso passa.
84. No ciclismo, não importa para onde você vai; é sempre morro acima e contra o vento.
85. Por mais tomadas que se tenham em casa, os móveis estão sempre na frente.
86. Existem dois tipos de esparadrapo: o que não gruda, e o que não sai.
87. Uma pessoa saudável é aquela que não foi suficientemente examinada.
88. Você sabe que é um dia ruim quando: O sol nasce no oeste; você pula da cama e erra o chão; o passarinho cantando lá fora é um urubu; seu bichinho de cerâmica te morde.
89. Por que será que números errados nunca estão ocupados?
90. Mas você nunca vai usar todo esse espaço de Winchester!
91. Se você não está confuso, não está prestando atenção.
92. Na guerra, o inimigo ataca em duas ocasiões: quando ele está preparado, e quando você não está.
93. Tudo que começa bem, termina mal. Tudo que começa mal, termina pior.
94. Amigos vêm e se vão, inimigos se acumulam.
95. "Pilhas não incluídas"
96. Você só precisará de um documento quando, espontaneamente, ele se mover do lugar que você o deixou para o lugar onde você não irá encontrá-lo.
97. As crianças são incríveis. Em geral, elas repetem palavra por palavra aquilo que você não deveria ter dito.
98. Uma maneira de se parar um cavalo de corrida é apostar nele.
99. Toda partícula que voa sempre encontra um olho.
100. Um morro nunca desce.

Ticiane

 

amar é admirar com  o coração

Ela é uma apresentadora (âncora) de um jornal de notícias da TV Bandeirantes.

Cada vez que ligo a TV e ela está apresentando as mais recentes notícias do Brasil e do mundo, eu não presto atenção às notícias.  Fico simplesmente vidrado nela, nas suas expressões, no seu maravilhoso sotaque nordestino, nos meneios de sua face, e principalmente na doçura de sua voz.

Ela é simplesmente maravilhosa. Não sei e nem quero saber como ela é em outras ocasiões, no seu lar, na sua vida cotidiana. Não deve ser muito diferente.  Se alguém me perguntasse qual seria meu ideal de uma figura feminina certamente Ticiane seria escolhida sem pestanejar.

Como eu gosto muito da música que transcrevo abaixo, dedico à Ticiane, com carinho.

SHE ( best performed by Engelbert Humperdinck)

She may be the face I can't forget
A trace of pleasure or regret
May be the treasure
Or the price I have to pay

She may be the song that summer sings
May be the chill that autumn brings
May be a hundred different things
Within the measure of a day

She may be the beauty or the beast
May be the famine or the feast
May turn each day into a heaven or a hell

She may be the mirror of my dreams
The smile reflected in the stream
She may not be what she may seem
Inside her shell

She who always seems so happy in a crowd,
Whose eyes can be so private and so proud
No ones allowed to see them when they cry

She may be the love that cannot hope to last
May come to me from shadows of the past
That I'd remember till the day I die

She may be the reason I survive
The why and wherefore I'm alive
The one I'll care for
Through the rough and ready years
Me, I'll take her laughter and her tears
And make them all my souvenirs
For where she goes I've got to be
The meaning of my life is She

She may be the love that cannot hope to last
May come to me from shadows of the past
That I'll remember till the day I die

She may be the reason I survive
The why and wherefore I'm alive
The one I'll care for
Through the rough and ready years
Me, I'll take her laughter and her tears
And make them all my souvenirs
For where she goes I've got to be
The meaning of my life is Ticiane…

 

 

                                                      Video >   https://www.youtube.com/watch?v=HeIs-yV5WNE

The social psychology of nerve cells


Cholinergic amacrine cells are distributed nonrandomly in the mouse retina.

The functional organization of the central nervous system depends upon a precise architecture and connectivity of distinct types of neurons. Multiple cell types are present within any brain structure, but the rules governing their positioning, and the molecular mechanisms mediating those rules, have been relatively unexplored.

A new study by UC Santa Barbara researchers demonstrates that a particular neuron, the cholinergic amacrine cell, creates a "personal space" in much the same way that people distance themselves from one another in an elevator. In addition, the study, published in the Proceedings of the National Academy of Sciences, shows that this feature is heritable and identifies a genetic contributor to it, pituitary tumor-transforming gene 1 (Pttg1).

Patrick Keeley, a postdoctoral scholar in Benjamin Reese's laboratory at UCSB's Neuroscience Research Institute, has been using the retina as a model system for exploring such principles of developmental neurobiology. The retina is ideal because this portion of the central nervous system lends itself to such spatial analysis.

"Populations of neurons in the retina are laid out in single strata within this layered structure, lending themselves to accurate quantitation and statistical analysis," explained Keeley. "Rather than being distributed as regular lattices of nerve cells, populations in the retina appear to abide by a simple rule, that of minimizing proximity to other cells of the same type. We would like to understand how such populations create and maintain such spacing behavior."

To address this, Keeley and colleagues quantified the regularity in the population of a particular type of amacrine cell in the mouse retina. They did so in 26 genetically distinct strains of mice and found that every strain exhibited this same self-spacing behavior but that some strains did so more efficiently than others. Amacrine cells are retinal interneurons that form connections between other neurons and regulate bipolar cell output.

"The regularity in the patterning of these amacrine cells showed little variation within each strain, while showing conspicuous variation between the strains, indicating a heritable component to this trait," said Keeley.

"This itself was something of a surprise, given that the patterning in such populations has an apparently stochastic quality to it," said Reese, a professor in the Department of Psychological and Brain Sciences. Stochastic systems are random and are analyzed, at least in part, using probability theory.

This strain variation in the regularity of this cellular patterning showed a significant linkage to a location in the genome on chromosome 11, where the researchers identified Pttg1, previously unknown to play any role in the retina.

Working in collaboration with colleagues at the University of Tennessee Health Science Center in Memphis, Keeley's team demonstrated that the expression of this gene varies across the 26 strains of mice and that there was a positive correlation between gene expression and regularity. They then identified a mutation in this gene that itself correlated with expression levels and with regularity. Working with colleagues at Cedars-Sinai Medical Center in Los Angeles, the team also demonstrated directly that this mutation controlled gene expression.

"Pttg1 has diverse functions, being an oncogene for pituitary tumors, and is known to have regulatory functions orchestrating gene expression elsewhere in the body," explained Keeley. "Within this class of retinal neurons, it should be regulating the way in which cells integrate signals from their immediate neighbors, translating that information to position the cell farthest from those neighbors." Future studies should decipher the genetic network controlled by Pttg1 that mediates such nerve-cell spacing.

Little progress made in reducing health disparities for people with disabilities

 

June 26, 2014

Health Behavior News Service

Mental distress in people with disabilities is associated with increased prevalence of chronic illness and reduced access to health care and preventive care services, finds a new study. "It's important to find out why there has been so little progress, since the prevention, detection, and treatment of secondary illnesses is critical for health maintenance, halting progression of disability, and helping people with disabilities to participate in life activities," says the lead author.


Psychological distress in people with disabilities is associated with increased prevalence of other chronic conditions and reduced access to health care and preventive care services, finds a new study in the Journal of Health Care for the Poor and Underserved.

The U.S. Department of Health and Human Services' Healthy People series established goals to reduce disparities among people with disabilities, but there has been very little progress toward reaching these goals, says lead author Catherine Okoro, Ph.D., of the Centers for Disease Control and Prevention (CDC) in Atlanta, Georgia.

"It's important to find out why there has been so little progress, since the prevention, detection, and treatment of secondary illnesses is critical for health maintenance, halting progression of disability, and helping people with disabilities to participate in life activities," she says.

The study analyzed data from the Behavioral Risk Factor Surveillance System, a telephone survey conducted in 2007 by most state health departments in conjunction with the CDC. Approximately 30 percent of adults with disabilities reported having moderate to serious psychological distress, with over 12 percent reporting serious psychological distress.

Adults who reported having a disability and serious psychological distress had a higher prevalence of seven chronic diseases and conditions -- arthritis, asthma, coronary heart disease, diabetes, hypertension, high cholesterol, and stroke -- when compared to adults with no psychological distress. Disabled adults with moderate psychological distress also had higher rates of these conditions, with the exception of diabetes.

"We found a strong association between increasing numbers of physical chronic conditions and prevalence of serious psychological distress," Okoro says. "For example, the prevalence of serious psychological distress was about two times as high among those with five to seven chronic conditions compared to those with no conditions."

Adults ages 18 to 64 with disabilities and moderate-to-serious psychological distress were also found to have several barriers to accessing health care. They were more likely to be uninsured and unable to afford care than those with no distress. Researchers found that the use of mental health services increased with the severity of psychological distress, but a larger proportion of older adults with serious psychological distress reported not receiving mental health care when compared to their younger counterparts. "It's possible this may be due to competing health conditions, stigma, or avoidance," Okoro comments.

The study illustrates that a relatively small but highly vulnerable population bears the majority of burden of poor physical and psychological health, says Benjamin Druss, M.D., a psychiatrist at Emory University. "These problems tend to be tangled up with one another so a person who has physical problems tends to be more stressed about their problems -- particularly if they can't get health care," he comments. "It's not easy to untangle all these issues, but these individuals should be treated in a holistic way, looking at their mental problems, their physical health, and their psychosocial issues," he adds.

Vegetarian diets produce fewer greenhouse gases and increase longevity, say new studies

 

June 25, 2014

Loma Linda University Medical Center

Consuming a plant-based diet results in a more sustainable environment and reduces greenhouse gas emissions, while improving longevity, according to new research. Based on findings that identified food systems as a significant contributor to global warming, the study focuses on the dietary patterns of vegetarians, semi-vegetarians and non-vegetarians to quantify and compare greenhouse gas emissions, as well as assess total mortality.


New research finds that consuming a plant-based diet results in a more sustainable environment and reduces greenhouse gas emissions, while improving longevity.

Consuming a plant-based diet results in a more sustainable environment and reduces greenhouse gas emissions, while improving longevity, according to new research from Loma Linda University Health.

A study and an article, produced by researchers at Loma Linda University School of Public Health, will be published in full in the July issue of the American Journal of Clinical Nutrition, and were first presented at the 6th International Congress on Vegetarian Nutrition in 2013.

Based on findings that identified food systems as a significant contributor to global warming, the study focuses on the dietary patterns of vegetarians, semi-vegetarians and non-vegetarians to quantify and compare greenhouse gas emissions, as well as assess total mortality.

The mortality rate for non-vegetarians was almost 20 percent higher than that for vegetarians and semi-vegetarians. On top of lower mortality rates, switching from non-vegetarian diets to vegetarian diets or even semi-vegetarian diets also helps reduce greenhouse gas emissions. The vegetarian diets resulted in almost a third less emissions compared to the non-vegetarian diets. Modifying the consumption of animal-based foods can therefore be a feasible and effective tool for climate change mitigation and public health improvements, the study concluded.

"The takeaway message is that relatively small reductions in the consumption of animal products result in non-trivial environmental benefits and health benefits," said Sam Soret, Ph.D., MPH, associate dean at Loma Linda University School of Public Health and co-author of the studies.

The study drew data from the Adventist Health Study, which is a large-scale study of the nutritional habits and practices of more than 96,000 Seventh-day Adventists throughout the United States and Canada. The study population is multi-ethnic and geographically diverse.

"The study sample is heterogeneous and our data is rich. We analyzed more than 73,000 participants. The level of detail we have on food consumption and health outcomes at the individual level makes these findings unprecedented," Soret said.

The analysis is the first of its kind to use a large, living population, since previous studies relating dietary patterns to greenhouse gas emissions and health effects relied on simulated data or relatively small populations to find similar conclusions.

"To our knowledge no studies have yet used a single non-simulated data set to independently assess the climate change mitigation potential and actual health outcomes for the same dietary patterns," said Joan Sabate, MD, DrPH, nutrition professor at Loma Linda University School of Public Health and co-author of the studies.

The accompanying article makes the case for returning to a large-scale practice of plant-based diets, in light of the substantial and detrimental environmental impacts caused by the current trend of eating diets rich in animal products. Making a switch to plant-based foods will increase food security and sustainability, thereby avoiding otherwise disastrous consequences.

Both papers demonstrate that the production of food for human consumption causes significant emissions of greenhouse gases and compare the environmental impacts of producing foods consumed by vegetarians and non-vegetarians.

Sabate noted that the results emphasize the need to reassess people's nutritional practices, in light of environmental challenges and worldwide population growth.

"Throughout history, forced either by necessity or choice, large segments of the world's population have thrived on plant-based diets," Sabate said.

The School of Public Health at Loma Linda University has a keen interest in studying environmental nutrition and has had a dedicated postdoctoral program for the last six years and a clearly defined research program, funded by the McLean Endowment.

Scientists unearth what may be secret weapon against antibiotic resistance

 

June 25, 2014

McMaster University

A fungus living in the soils of Nova Scotia could offer new hope in the pressing battle against drug-resistant germs that kill tens of thousands of people every year, including one considered a serious global threat. Seeking an answer to the riddle of resistance in the natural environment is a far more promising approach than trying to discover new antibiotics, a challenge which has perplexed scientists for decades. No new classes of antibiotics have been discovered since the late 1980s, leaving physicians with very few tools to fight life-threatening infections.


Andrew King, a chemical biology graduate student at McMaster University examines a chemical used in drug discovery research.

A fungus living in the soils of Nova Scotia could offer new hope in the pressing battle against drug-resistant germs that kill tens of thousands of people every year, including one considered a serious global threat.

A team of researchers led by McMaster University has discovered a fungus-derived molecule, known as AMA, which is able to disarm one of the most dangerous antibiotic-resistance genes: NDM-1 or New Delhi Metallo-beta-Lactamase-1, identified by the World Health Organization as a global public health threat.

"This is public enemy number one," explains Gerry Wright, director of the Michael G. DeGroote Institute for Infectious Disease Research at McMaster University.

"It came out of nowhere, it has spread everywhere and has basically killed our last resource of antibiotics, the last pill on the shelf, used to treat serious infections," he says.

Discovering the properties of the fungus-derived molecule is critical because it can provide a means to target and rapidly block the drug-resistant pathogens that render carbapenem antibiotics -- a class of drugs similar to penicillin -- ineffective.

"Simply put, the molecule knocks out NDM-1 so the antibiotics can do their job," says Wright.

Seeking an answer to the riddle of resistance in the natural environment is a far more promising approach than trying to discover new antibiotics, a challenge which has perplexed scientists for decades. No new classes of antibiotics have been discovered since the late 1980s, leaving physicians with very few tools to fight life-threatening infections.

"Not only do we have the emergence of an antibiotic resistance gene that is targeting the last drug resource we have left, but it is carried by organisms that cause all sorts of challenging diseases and are multi-drug-resistant already. It has been found not only in clinics but in the environment -- in contaminated water in South Asia -- which has contributed to its spread over the globe," explains Wright. "Our thinking was that if we could find a molecule that blocks NDM-1 then these antibiotics would be useful again."

Wright and his team from McMaster, University of British Columbia and Cardiff University in Wales created a sophisticated screening method to take the NDM-1 gene, combine it with harmless E. coli bacteria and then isolate a molecule capable of stopping NDM-1 in its tracks.

NMD-1 requires zinc to thrive but finding a way to remove zinc from it without causing a toxic effect in humans was a daunting task, until the discovery of the fungal molecule, which appears to perform the job naturally and harmlessly.

Scientists then tested the theory on mice infected with an NDM-1 expressing superbug. The mice that received a combination of the AMA molecule and a carbapenem antibiotic survived, while those that received either an antibiotic or AMA alone to fight the infection did not survive.

"This will solve one aspect of a daunting problem. AMA rescues the activity of carbapenem antibiotics, so instead of having no antibiotics, there will be some," says Wright. "This is a made-in-Canada solution for a global problem."

"Antibiotic resistance may be the most urgent and perplexing challenge facing health-care researchers today," says Dr. John Kelton, dean of the Michael G. DeGroote School of Medicine and vice-president of the Faculty of Health Sciences at McMaster. "This research provides new hope by showing us a completely new way to approach this problem, and none too soon, given the growing risk that superbugs pose to all of us. "

The findings are published online in the current edition of the journal Nature.

"Antibiotic resistance is one of the top public health concerns in Canada and internationally and it represents a research priority for the Canadian Institutes of Health Research (CIHR). It is exciting to see Canadian researchers finding innovative strategies to overcome antimicrobial resistance," says Dr. Marc Ouellette, scientific director of the CIHR Institute of Infection and Immunity.


Story Source:

The above story is based on materials provided by McMaster University. The original article was written by Michelle Donovan. Note: Materials may be edited for content and length.

Collaborative learning -- for robots: New algorithm

 

June 25, 2014

Massachusetts Institute of Technology

Machine learning, in which computers learn new skills by looking for patterns in training data, is the basis of most recent advances in artificial intelligence, from voice-recognition systems to self-parking cars. It's also the technique that autonomous robots typically use to build models of their environments. A new algorithm lets independent agents collectively produce a machine-learning model without aggregating data.


Scientists have presented an algorithm in which distributed agents -- such as robots exploring a building -- collect data and analyze it independently. Pairs of agents, such as robots passing each other in the hall, then exchange analyses. (stock image)

Machine learning, in which computers learn new skills by looking for patterns in training data, is the basis of most recent advances in artificial intelligence, from voice-recognition systems to self-parking cars. It's also the technique that autonomous robots typically use to build models of their environments.

That type of model-building gets complicated, however, in cases in which clusters of robots work as teams. The robots may have gathered information that, collectively, would produce a good model but which, individually, is almost useless. If constraints on power, communication, or computation mean that the robots can't pool their data at one location, how can they collectively build a model?

At the Uncertainty in Artificial Intelligence conference in July, researchers from MIT's Laboratory for Information and Decision Systems will answer that question. They present an algorithm in which distributed agents -- such as robots exploring a building -- collect data and analyze it independently. Pairs of agents, such as robots passing each other in the hall, then exchange analyses.

In experiments involving several different data sets, the researchers' distributed algorithm actually outperformed a standard algorithm that works on data aggregated at a single location.

"A single computer has a very difficult optimization problem to solve in order to learn a model from a single giant batch of data, and it can get stuck at bad solutions," says Trevor Campbell, a graduate student in aeronautics and astronautics at MIT, who wrote the new paper with his advisor, Jonathan How, the Richard Cockburn Maclaurin Professor of Aeronautics and Astronautics. "If smaller chunks of data are first processed by individual robots and then combined, the final model is less likely to get stuck at a bad solution."

Campbell says that the work was motivated by questions about robot collaboration. But it could also have implications for big data, since it would allow distributed servers to combine the results of their data analyses without aggregating the data at a central location.

"This procedure is completely robust to pretty much any network you can think of," Campbell says. "It's very much a flexible learning algorithm for decentralized networks."

Matching problem

To get a sense of the problem Campbell and How solved, imagine a team of robots exploring an unfamiliar office building. If their learning algorithm is general enough, they won't have any prior notion of what a chair is, or a table, let alone a conference room or an office. But they could determine, for instance, that some rooms contain a small number of chair-shaped objects together with roughly the same number of table-shaped objects, while other rooms contain a large number of chair-shaped objects together with a single table-shaped object.

Over time, each robot will build up its own catalogue of types of rooms and their contents. But inaccuracies are likely to creep in: One robot, for instance, might happen to encounter a conference room in which some traveler has left a suitcase and conclude that suitcases are regular features of conference rooms. Another might enter a kitchen while the coffeemaker is obscured by the open refrigerator door and leave coffeemakers off its inventory of kitchen items.

Ideally, when two robots encountered each other, they would compare their catalogues, reinforcing mutual observations and correcting omissions or overgeneralizations. The problem is that they don't know how to match categories. Neither knows the label "kitchen" or "conference room"; they just have labels like "room 1" and "room 3," each associated with different lists of distinguishing features. But one robot's room 1 could be another robot's room 3.

With Campbell and How's algorithm, the robots try to match categories on the basis of shared list items. This is bound to lead to errors: One robot, for instance, may have inferred that sinks and pedal-operated trashcans are distinguishing features of bathrooms, another that they're distinguishing features of kitchens. But they do their best, combining the lists that they think correspond.

When either of those robots meets another robot, it performs the same procedure, matching lists as best it can. But here's the crucial step: It then pulls out each of the source lists independently and rematches it to the others, repeating this process until no reordering results. It does this again with every new robot it encounters, gradually building more and more accurate models.

Imposing order

This relatively straightforward procedure results from some pretty sophisticated mathematical analysis, which the researchers present in their paper. "The way that computer systems learn these complex models these days is that you postulate a simpler model and then use it to approximate what you would get if you were able to deal with all the crazy nuances and complexities," Campbell says. "What our algorithm does is sort of artificially reintroduce structure, after you've solved that easier problem, and then use that artificial structure to combine the models properly."

In a real application, the robots probably wouldn't just be classifying rooms according to the objects they contain: They'd also be classifying the objects themselves, and probably their uses. But Campbell and How's procedure generalizes to other learning problems just as well.

The example of classifying rooms according to content, moreover, is similar in structure to a classic problem in natural language processing called topic modeling, in which a computer attempts to use the relative frequency of words to classify documents according to topic. It would be wildly impractical to store all the documents on the Web in a single location, so that a traditional machine-learning algorithm could provide a consistent classification scheme for all of them. But Campbell and How's algorithm means that scattered servers could churn away on the documents in their own corners of the Web and still produce a collective topic model.

"Distributed computing will play a critical role in the deployment of multiple autonomous agents, such as multiple autonomous land and airborne vehicles," says Lawrence Carin, a professor of electrical and computer engineering and vice provost for research at Duke University. "The distributed variational method proposed in this paper is computationally efficient and practical. One of the keys to it is a technique for handling the breaking of symmetries manifested in Bayesian inference. The solution to this problem is very novel and is likely to be leveraged in the future by other researchers."


Story Source:

The above story is based on materials provided by Massachusetts Institute of Technology. The original article was written by Larry Hardesty. Note: Materials may be edited for content and length.

A farewell to arms? Scientists developing a novel technique that could facilitate nuclear disarmament

 

Scientists at Princeton University and the U.S. Department of Energy's (DOE) Princeton Plasma Physics Laboratory (PPPL) are developing the prototype for such a system, as reported this week in Nature magazine. Their novel approach, called a "zero-knowledge protocol," would verify the presence of warheads without collecting any classified information at all.

"The goal is to prove with as high confidence as required that an object is a true nuclear warhead while learning nothing about the materials and design of the warhead itself," said physicist Robert Goldston, coauthor of the paper, a fusion researcher and former director of PPPL, and a professor of astrophysical sciences at Princeton.

While numerous efforts have been made over the years to develop systems for verifying the actual content of warheads covered by disarmament treaties, no such methods are currently in use for treaty verification.

Counting warheads

Traditional nuclear arms negotiations focus instead on the reduction of strategic -- or long-range -- delivery systems, such as bombers, submarines and ballistic missiles, without verifying their warheads. But this approach could prove insufficient when future talks turn to tactical and nondeployed nuclear weapons that are not on long-range systems. "What we really want to do is count warheads," said physicist Alexander Glaser, first author of the paper and an assistant professor in Princeton's Woodrow Wilson School of Public and International Affairs and the Department of Mechanical and Aerospace Engineering.

The system Glaser and Goldston are mapping out would compare a warhead to be inspected with a known true warhead to see if the weapons matched. This would be done by beaming high-energy neutrons into each warhead and recording how many neutrons passed through to detectors positioned on the other side. Neutrons that passed through would be added to those already "preloaded" into the detectors by the warheads' owner -- and if the total number of neutrons were the same for each warhead, the weapons would be found to match. But different totals would show that the putative warhead was really a spoof. Prior to the test, the inspector would decide which preloaded detector would go with which warhead.

No classified data would be measured in this process, and no electronic components that might be vulnerable to tampering and snooping would be used. "This approach really is very interesting and elegant," said Steve Fetter, a professor in the School of Public Policy at the University of Maryland and a former White House official. "The main question is whether it can be implemented in practice."

PPPL project

A project to test this approach is under construction at PPPL. The project calls for firing high-energy neutrons at a non-nuclear target, called a British Test Object, that will serve as a proxy for warheads. Researchers will compare results of the tests by noting how many neutrons pass through the target to bubble detectors that Yale University is designing for the project. The gel-filled detectors will add the neutrons that pass through to those already preloaded to produce a total for each test.

The project was launched with a seed grant from the Simons Foundation of Vancouver, Canada, that came to Princeton through Global Zero, a nonprofit organization. Support also was provided by the U.S. Department of State, the DOE (via PPPL pre-proposal development funding), and most recently, a total of $3.5 million over five years from the National Nuclear Security Administration.

Glaser hit upon the idea for a zero-knowledge proof over a lunch hosted by David Dobkin, a computer scientist, and until June 2014, dean of the Princeton faculty. "I told him I was really interested in nuclear warhead verification without learning anything about the warhead itself," Glaser said. '"We call this a zero-knowledge proof in computer science,"' Glaser said Dobkin replied. "That was the trigger," Glaser recalled. "I went home and began reading about zero-knowledge proofs," which are widely used in applications such as verifying online passwords.

Disguising information

Glaser's reading led him to Boaz Barak, a senior researcher at Microsoft New England who had taught computer science at Princeton and is an expert in cryptology, the science of disguising secret information. "We started having discussions," Glaser said of Barak, who helped develop statistical measures for the PPPL project and is the third coauthor of the paper in Nature.

Glaser also reached out to Goldston, with whom he had taught a class for three years in the Princeton Department of Astrophysical Sciences. "I told Rob that we need neutrons for this project," Glaser recalled. "And he said, 'That's what we do -- we have 14 MeV [or high-energy] neutrons at the Laboratory.'" Glaser, Goldston and Barak then worked together to refine the concept, developing ways to assure that even the statistical noise -- or random variation -- in the measurements conveyed no information.

If proven successful, dedicated inspection systems based on radiation measurements, such as the one proposed here, could help to advance disarmament talks beyond the New Strategic Arms Reduction Treaty (New START) between the United States and Russia, which runs from 2011 to 2021. The treaty calls for each country to reduce its arsenal of deployed strategic nuclear arms to 1,550 weapons, for a total of 3,100, by 2018.

Not included in the New START treaty are more than 4,000 nondeployed strategic and tactical weapons in each country's arsenal. These very weapons, note the authors of the Nature paper, are apt to become part of future negotiations, "which will likely require verification of individual warheads, rather than whole delivery systems." Deep cuts in the nuclear arsenals and the ultimate march to zero, say the authors, will require the ability to verifiably count individual warheads.