sábado, 17 de outubro de 2015

Sweet Potato Rolls

 

 

Sweet Potato Rolls - Photo: Diana Rattray

Homemade Sweet Potato Yeast Rolls.  Photo: Diana Rattray

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These great tasting yeast rolls are kneaded in the bread machine, making them a snap to prepare, shape, and bake.

Ingredients
  • 3/4 cup milk
  • 1 cup mashed or pureed cooked sweet potato
  • 3 tablespoons melted butter plus a little for the tops when the rolls come out of the oven
  • 1 large egg, beaten
  • 4 cups all-purpose flour
  • 4 tablespoons granulated sugar
  • 1 teaspoon salt
  • 2 1/4 teaspoons active dry yeast
  • Yield: Makes 24 Rolls
Preparation

Add all ingredients to the bread machine in the order suggested by the manufacturer. Use the basic dough cycle. When the cycle finishes, tear pieces off of the dough to make balls, and place in a greased 9-inch square baking pan so they're just touching but not too close. I make the balls about 1 3/4 ounces each and get about 24 rolls.

Cover with a cloth and let rise for about 45 minutes in a warm, draft-free place.

Bake in a 375° oven for about 20 to 23 minutes, until nicely browned. Brush the tops with melted or softened butter while they're hot.

More Yeast Rolls and Bread:
Dinner Rolls
Clover Leaf Rolls
Sweet Potato Yeast Bread
Potato Cheese Rolls

 

http://southernfood.about.com/od/breadmachine/r/Sweet-Potato-Rolls.htm

Preventing drug use from becoming addiction would have health, financial benefits

 

 

A few minutes of counseling in a primary care setting could go a long way toward steering people away from risky drug use, and possibly full-fledged addiction, a UCLA-led study suggests.

People who participated in the Quit Using Drugs Intervention Trial, or Project QUIT, which was a randomized controlled trial conducted in medical clinics, reduced their risky drug use by one-third when primary care doctors and health coaches provided them with brief interventions during a routine visit and follow-up phone calls, said Dr. Lillian Gelberg, lead investigator and professor of family medicine at the David Geffen School of Medicine at UCLA.

Risky drug use is defined as the casual, frequent or binge use of illicit drugs such as cocaine, heroin and methamphetamine, or the misuse of prescription medications, without showing physiological or psychological signs of addiction. There are an estimated 68 million such drug users in the United States. These people are at risk not only for becoming addicts, but suffering attendant physical, mental health and social problems.

The study, published in the peer-reviewed journal Addiction, is the first to demonstrate that a brief intervention led by a primary care physician can significantly reduce risky drug use among patients.

"Risky drug use is a very important health problem because it can develop into drug addiction, which is a chronic relapsing brain disease with permanent effects and that is more costly to treat," said Gelberg, who is also professor of public health at the UCLA Fielding School of Public Health. "It is important to reduce risky drug use before it becomes a chronic brain disease, at a time when patients may still have the power to do so."

The researchers recruited 334 adult primary-care patients at five federally qualified health centers in Los Angeles County. People were chosen among those whose scores on the World Health Organization's Alcohol, Smoking and Substance Involvement Screening Test indicated risky drug use.

The study subjects were randomly assigned to one of two groups: 171 in the intervention group and 163 who served as controls. The clinics serve low-income communities with high rates of drug use.

Intervention group participants received brief face-to-face advice from their primary care provider during their visits, a drug health education booklet with a card to report their drug use, and watched a two-minute "video doctor" reinforcing the clinician's message. During the brief advice, which typically lasted three to four minutes with only three lasting 10 minutes, the primary care provider discussed drug addiction as a chronic brain disease, the need to reduce or quit using drugs in order to avoid addiction, the physical and mental effects of drug use, and how use of multiple drugs can accelerate the progression toward addiction. They also received one or two 20- to 30-minute follow up telephone coaching sessions two and six weeks later.

The control patients were given a two-minute "video doctor" presentation about cancer screening and an information booklet on cancer screening. They were also given information about cancer screening, rather than about drugs, to provide them some level of attention in an area unlikely to affect their drug use. They did not receive the advice about drug-use reduction from the primary care provider or the follow-up phone coaching sessions until the study was completed.

After three months, intervention group participants reported that they used their favored drug an average of 3.5 fewer days in the previous month compared to control group participants. This was a 33 percent reduction in their drug use.

The study has some limitations. The results are based on participants' self-reporting, so the study may suffer from reporting bias. However, researchers found that based on urine testing, under-reporting of drug use was low. Additional limitations: not everyone in the clinic waiting rooms agreed to participate, which could impact the study's generalizability; there was some attrition during the study, though the 75 percent participation rate at follow-up compares to other studies of low income patients and drug use; and the three month follow up was relatively short.

There is a need for larger trials to gauge the QUIT program's effectiveness, but based on these findings the project appears to have the potential to fill an important gap in care for patients who use drugs, particularly in low-income communities, Gelberg said.

"In the U.S., the recent expansion of health care coverage through the Affordable Care Act and the Mental Health Parity and Addiction Equity Act has broadened behavioral health coverage to some 62 million people, providing multiple opportunities for brief intervention programs for risky drug use in community health centers and other primary care settings," she said.

http://www.sciencedaily.com/releases/2015/10/151016094146.htm

Researchers' cure of metastatic skin cancer revealed

 

 

Identifying a patient’s genetic mutation led University of Arkansas for Medical Sciences (UAMS) physician-researcher Ling Gao, M.D., Ph.D., to an existing drug that eliminated the patient’s stage IV Merkel-cell carcinoma. Gao’s findings, made in collaboration with two other UAMS researchers, were published today inThe New England Journal of Medicine.

Metastatic Merkel-cell carcinoma is often fatal and there is no effective treatment. Gao’s 86-year-old female patient was diagnosed in 2013 with stage IIIB Merkel-cell carcinoma of the right temple. She had surgery and received radiation therapy in May 2013 and additional surgery in July 2014. In November 2014, doctors confirmed that the cancer had metastasized.

Gao, a dermatologist who treats Merkel-cell carcinoma patients from Arkansas and surrounding states, performed genetics tests on the tumor that revealed multiple mutations, including PI3Kδ.

Gao was aware that the drug idelalisib is a novel PI3K pathway inhibitor approved by the Food and Drug Administration (FDA) for treatment of B-cell lymphoma, a cancer of the blood. She was also aware of recent studies showing that disruption of the PI3Kδ mutation allows the body to mount an effective antitumor immune response.

On the basis of her laboratory work and knowledge of idelalisb, Gao began treatment of the patient with the drug on Feb. 6, 2015. Her findings were published in the Journal in a letter to the editor.

Three months after administering the idelalisib, there was no sign of the tumor in the patient’s liver, Gao said

Based on what she’s learned, Gao said the case can be made for further study of PI3Kδ inhibitors like idelalisib in solid tumors, not just blood cancers.

“The efficacy of idelalisib in our patient provides initial clinical evidence that the targeting of PI3Kδ in Merkel-cell carcinoma is warranted,” Gao said in the letter, which
was also signed by UAMS’ Fade Mahmoud, M.D., and Mallory B. Shiver, M.D.

Gao also credits support she received from Peter Emanuel, M.D., director of the UAMS Winthrop P. Rockefeller Cancer Institute, and James Suen, M.D., chair of the Department of Otolaryngology-Head and Neck Surgery in the UAMS College of Medicine.


Story Source:

The above post is reprinted from materials provided by University of Arkansas for Medical Sciences. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mallory B. Shiver, Fade Mahmoud, Ling Gao. Response to Idelalisib in a Patient with Stage IV Merkel-Cell Carcinoma. New England Journal of Medicine, 2015; 373 (16): 1580 DOI: 10.1056/NEJMc1507446

http://www.sciencedaily.com/releases/2015/10/151016094221.htm