sábado, 25 de abril de 2015

New app helps reduce food waste

 

By Katherine Zeratsky, R.D., L.D. April 17, 2015

Food waste is more than an inconvenience. Wasted food is wasted money. It's a missed opportunity to feed those in need. It's an environmental hazard as it creates methane gas, which endangers the ozone layer.

To help consumers make better use of the food they purchase, the U.S. Department of Agriculture collaborated with Cornell University and the Food Marketing Institute to create the FoodKeeper app. The FoodKeeper app is free and available for both Android and Apple devices.

The FoodKeeper app offers storage advice about more than 400 food and beverage items. It also has the following features:

  • Storage guidelines for specific foods and storage conditions — refrigerator, freezer and room temperature
  • Cooking tips for meat, fish and eggs to keep you safe from foodborne illnesses
  • Interactive calendar function to help you manage your food storage

This app is part of a larger effort, called the U.S. Food Waste Challenge, aimed at:

  • Reducing food waste by improving how food is produced, stored, labeled and cooked
  • Recovering food waste by connecting usable food to food banks and pantries
  • Recycling food waste to feed animals or create compost, natural fertilizers and bioenergy

What are your thoughts about food waste? What is your personal goal for better use of food? Is it financial, environmental or something else? Please share how you manage your food for best use.

April 17, 2015

Fresh understanding of what causes asthma opens door for new treatment

 

 

Cardiff University's Professor Daniela Riccardi says that if human trials of a drug to tre...

Cardiff University's Professor Daniela Riccardi says that if human trials of a drug to treat asthma are successful, a cure could be on the horizon (Photo: Cardiff University)

Sufferers of asthma live with a constant unease that an attack can strike at any time. Equally disconcerting is our lack of understanding of its causes and where a cure might come from. But researchers at Cardiff University may have just lifted the veil on this condition, claiming to have not only uncovered its root cause, but drugs that can curtail its symptoms.

In their research, the scientists worked with mouse models and human airway tissue from both sufferers and non-sufferers of asthma. They were able to identify the exact cells that narrow the airways and set off an attack.

The team established that environmental triggers like allergens and cigarette smoke activate a receptor known as the calcium sensing receptor (CaSR). It found this in turn to be the driver of asthma symptoms that make breathing difficult.

But the good news doesn't stop there. They say CaSR can be neutralized with existing drugs called calcilytics, first produced around 15 years ago as a treatment candidate for osteoporosis.

"Our paper shows how these triggers release chemicals that activate CaSR in airway tissue and drive asthma symptoms like airway twitchiness, inflammation, and narrowing," says principal investigator Professor Daniela Riccardi. "Using calcilytics, nebulized directly into the lungs, we show that it is possible to deactivate CaSR and prevent all of these symptoms."

For many sufferers of asthma, its symptoms can be kept under control through inhalers and medicine. But around five percent don't respond too well to available treatments, and it is for this minority that this breakthrough could have a huge impact.

The team is now shifting its focus to facilitating human trials within two years. It is hopeful that successful trials will lead to new forms of treatment and ultimately, the prevention of asthma all together.

"If we can prove that calcilytics are safe when administered directly to the lung in people, then in five years we could be in a position to treat patients and potentially stop asthma from happening in the first place," says Riccardi.

The research was published in the journal Science Translational Medicine.

Source: Cardiff University

 

17 photos that prove just how cool the 1920s really were

 

 

We don’t really need to tell you that the 1920s were cool. The Roaring Twenties were characterized by prosperity and independence and people today are still fascinated by this decadent period in time. How could a decade that gave us flappers, fantastic fashion, the Jazz Age, women earning the right to vote, and a major technological boom be considered anything but cool? But just in case you still have doubt, check out these 17 photos that prove just how cool the 1920s really were.

Rebel with a garter flask, 1926

Rebel with a garter flask, 1926

NYC policeman, 1920

A New York City policeman hanging out, 1920

1920s fashion

A couple of fashionable women, 1920s

Two cyclists (Vervaeke and Geldhol) smoking during the 1920 Tour de France.

Two cyclists, Vervaeke and Geldhol, smoking during the 1920 Tour de France.

Miss Universe Ella Van Hueson, circa June 16, 1928.

Miss Universe Ella Van Hueson, circa June 16, 1928.

Charleston, 1920s

Dancing the Charleston on a railing in front of the US Capitol.

Group taking a selfie photo in 1920.

Group taking a selfie photo in 1920.

Mugshot, 1925

Even the mugshots were cool (1925).

Silent film star Evelyn Brent, 1924.

Silent film star Evelyn Brent, 1924.

Harry Houdini demonstrates photo manipulation by taking a

Harry Houdini demonstrates photo manipulation by taking a “spirit photograph” with Abraham Lincoln, 1920s

Bulgarian photobomber, 1926

Bulgarian photobomber, 1926

Washington Cat Show at the Wardman Park Hotel in Washington D.C., 1920s.

Washington Cat Show at the Wardman Park Hotel in Washington D.C.

Cambridge Undergraduates c. 1926

Cambridge undergraduates, 1926

1920s amusement park

1920s amusement park

1924

Three young men in a vehicle, c. 1924

Bessie_Coleman_and_her_plane_1922

Aviator Bessie Coleman and her plane in 1922

Sharpshooter Annie Oakley, with a gun that Buffalo Bill gave her, 1922.

Sharpshooter Annie Oakley with a gun that Buffalo Bill gave her.

Danger in using car seats, sitting and carrying devices for sleeping infants

 

Sleep-related deaths are the most common cause of death for infants 1-12 months of age. The American Academy of Pediatrics recommends that infants sleep on their back on a firm mattress, without loose bedding. However, many parents use sitting or carrying devices, such as car seats, swings, or bouncers, as alternative sleeping environments, which could lead to potential injury or death. In a new study scheduled for publication in The Journal of Pediatrics, researchers describe how the improper use of these items can lead to infant deaths.

Erich K. Batra, MD, Penn State Milton S. Hershey Medical Center, and colleagues from the US Consumer Product Safety Commission and Children's National Medical Center reviewed deaths that were reported to the US Consumer Product Safety Commission, of children under 2 years of age that occurred in sitting and carrying devices between April 2004 and December 2008. According to Dr. Batra, "Many parents use sitting or carrying devices, not realizing that there are hazards when they do this." The data include information from death certificates, reports from medical examiners and coroners, and interviews with family members and witnesses.

The researchers analyzed records for 47 deaths associated with sitting and carrying devices; all but one were attributed to asphyxia (positional or strangulation). Two-thirds of the cases involved car seats; strangulation from straps accounted for 52% of the car seat deaths. The remainder of deaths occurred in slings, swings, bouncers, and strollers. The elapsed time from when the infants were last seen alive to when they were discovered ranged from as little as four minutes to up to 11 hours. The study included newborns as well as toddlers.

It is important to note that an infant in a properly positioned car seat, in a car, with properly attached straps is at little risk from a suffocation injury. However, contrary to popular belief, the restraints and design of infant sitting or carrying devices are not intended for unsupervised sleeping. "Infants and young children should not be left unsupervised when using a sitting or carrying device due to the risk of suffocation and death," notes Dr. Batra.

The authors offer the following advice to parents when using infant sitting or carrying devices:

  1. Do not leave children unsupervised (awake or asleep);
  2. Never leave children in a car seat with unbuckled or partially buckled straps;
  3. Car seats should never be placed on a soft or unstable surface;
  4. Infants in bouncers, strollers, and swings may be able to maneuver into positions that could compromise their airway; straps on these devices may not prevent infants from getting into hazardous situations;
  5. Ensure that infants cannot twist their heads into soft bedding or slump forward in a seat; restraints should be used according to manufacturer's instructions;
  6. Slings are particularly hazardous because of their design and the ease with which an infant's airway can be collapsed. If used, the infant's face should be "visible and kissable" at all times; and
  7. Do not place more than one infant together in a swing meant for one infant.

Story Source:

The above story is based on materials provided by Elsevier. Note: Materials may be edited for content and length.


Journal Reference:

  1. Erich K. Batra, Jonathan D. Midgett, and Rachel Y. Moon. Hazards Associated with Sitting and Carrying Devices for Children Two Years and Younger. The Journal of Pediatrics, 2015 DOI: 10.1016/j.jpeds.2015.03.044

 

Delayed diagnosis of celiac disease may put lives at risk: Is screening the solution?

 

Celiac disease is one of the most common life-long conditions in Europe, yet many people remain undiagnosed and lengthy diagnostic delays may be putting lives at risk. Today, doctors are being urged to consider testing for Celiac disease in anyone showing signs and symptoms of the condition and to consider screening everyone in high-risk groups.

A paper published in this month's special Celiac disease (CD) issue of the UEG Journal assessed the viability of screening for CD in the general population and concluded that screening of first-degree relatives of people with CD, people with type 1 diabetes, iron-deficiency anemia, Down's syndrome and other high-risk groups may be appropriate.1

"This important research highlights the value of serological testing for CD in anyone with symptoms that might be due to the condition and in all asymptomatic individuals from high-risk groups," says Professor Antonio Gasbarrini from the Gemelli University Hospital in Rome, Italy. "It is vital that we now start to take positive action across Europe to tackle this prevalent condition and reduce its serious health consequences."

A diagnosis of CD is usually made based on the presence of antibodies to gluten in the blood in addition to biopsy evidence of inflammation in the small intestine.2 However, the availability of sensitive and specific blood tests for markers of CD has raised the possibility of population-wide screening for CD in an effort to ensure earlier diagnosis and treatment of the condition.

"Celiac disease is readily treated with a gluten-free diet, so it is unacceptable that people suffer its symptoms for many years before they are properly diagnosed" says Professor Gasbarrini. "We now have blood screening tests that are simple, safe and accurate, and it is time we started using them effectively to limit the damage caused by this common condition."

Celiac disease is a genetically-determined, autoimmune condition caused by a permanent intolerance to gluten found in wheat, barley and rye. The condition causes inflammation in the small intestine, leading to diarrhea, weight loss, fatigue and other non-specific symptoms. It has been estimated that around 1% of the population may have CD, although estimates vary between countries, and the prevalence of CD appears to be increasing.1 If left undiagnosed and untreated, CD can have a profound effect on quality of life,3 may lead to adverse pregnancy outcomes,4 and has been associated with a reduced life-expectancy.5

"Unfortunately, because the symptoms of CD are often vague and similar to those of irritable bowel syndrome, many people with CD are undiagnosed and many who are diagnosed will have waited 10 years or more for their diagnosis to be confirmed," says Prof. Gasbarrini. "At best, only around one-quarter of all CD sufferers are likely to have been diagnosed by a physician,6 leaving large numbers of people still at risk."

References

  1. Ludvigsson JF, Card TR, Kaukinen K, et al. UEG Journal 2015;3(2):106-120.
  2. Ludvigsson JF, Bai JC, Biagi F, et al. Gut 2013; 62:43-52.
  3. Norström F, Lindholm L, Sandström O, et al. BMC Gastroenterol 2011;11:118.
  4. Khashan AS, Henriksen TB, Mortensen PB, et al. Hum Reprod 2010;25(2):528-34.
  5. Rubio-Tapia A, Kyle RA, Kaplan EL, et al. Gastroenterology 2009;137(1):88-93. 6. Mustalahti K, Catassi C, Reunanen A, et al. Ann Med 2010;42:587-95.

Nuclear waste: Bury nuclear waste down a very deep hole, say scientists

 

Scientists at the University of Sheffield calculate that all of the UK's high level nuclear waste from spent fuel reprocessing could be disposed of in just six boreholes 5km deep, fitting within a site no larger than a football pitch.

The concept -- called deep borehole disposal -- has been developed primarily in the UK but is likely to see its first field trials in the USA next year. If the trials are successful, the USA hopes to dispose of its 'hottest' and most radioactive waste -- left over from plutonium production and currently stored at Hanford in Washington State -- in a deep borehole.

University of Sheffield researchers are presenting the latest findings relating to these trials and new concepts for sealing the waste into the boreholes at the American Nuclear Society (ANS) conference in Charleston this week (April 13-16).

Professor Fergus Gibb, of the University of Sheffield's Faculty of Engineering, explains: "Deep borehole disposal is particularly suitable for high level nuclear waste, such as spent fuel, where high levels of radioactivity and heat make other alternatives very difficult. Much of the drilling expertise and equipment to create the boreholes already exists in the oil and gas and geothermal industries. A demonstration borehole -- such as is planned in the US -- is what is now needed to move this technology forward."

At the ANS conference next week, Professor Gibb, with co-researcher Dr Karl Travis, will be presenting modelling work carried out by the University of Sheffield team on the Hanford waste, which confirms that around 40 per cent of the waste, in terms of radioactivity, currently stored at the US site could be disposed of in a single borehole.

Fundamental to the success of deep borehole disposal is the ability to seal the hole completely to prevent radionuclides getting back up to the surface. Professor Gibb has designed a method to do this which he will be presenting at the conference next week: to melt a layer of granite over the waste, which will re-solidify to have the same properties as natural rock.

Professor Gibb's colleague at the University of Sheffield, Dr Nick Collier, will propose a method of fixing and surrounding the waste within the borehole using specialist cements able to handle the temperatures and pressures at that depth.

Deep borehole disposal (DBD) has a number of advantages over the current solution envisaged for all UK nuclear waste, which is in a mined repository at 500m depth:

  • DBD is effectively 'pay-as-you-go' disposal. A mined repository can cost from hundreds of millions to tens of billions of dollars to construct before any waste can be disposed of; DBD costs a few tens of millions of dollars per borehole.
  • There are more geological sites suitable for DBD as the granite layer that is required can be found at appropriate depths under most of the continental crust.
  • A borehole could be drilled, filled and sealed in less than five years, compared to the current timescale for a UK mined repository, which is to open in 2040 and take its first waste by 2075 (although a site has not yet been agreed).
  • As DBD disposes of nuclear waste at greater depths and with greater safety and because there are more potential sites available, it should be easier to obtain public and political acceptance of the technology.
  • DBD has limited environmental impact and does not require a huge site: the holes are a maximum 0.6m in diameter and can be positioned just a few tens of metres apart. Once a borehole is complete, all physical infrastructure on the surface can be removed.
  • While seismic activity might damage the containers within the borehole, fracture the surrounding rock and disrupt some of the nearest barriers in the borehole, it would still not destroy the isolation of the waste or make it possible for radioactivity to reach the surface or any ground water.

The demonstration borehole in the USA will be drilled just under half a metre in diameter and trials will be conducted to ensure waste packages can be inserted into the borehole and recovered if required. Initial results are expected in 2016. If these results are positive, disposal of the Hanford waste capsules would then take place in another borehole, just 0.22m in diameter.

10 steps to building a successful business

 

 

A man walks past buildings at the central business district of Singapore

Building a business is no easy feat. As a two-time entrepreneur, I’ve experienced the ups and downs of building a company and culture. Aside from my children, however, there is nothing I’m prouder of than the two great companies we’ve built: Likeable Media and Likeable Local. As we celebrate Small Business Saturday, here are 10 simple steps I took to build our first company, and a blueprint you can use to build a business of your own:

1. Find a Trustworthy Partner
In my early 20s, I was working in sales at Radio Disney. I was the No. 1 sales person in the country until this woman came into my office and dropped me to No. 2 in just four months. I was shocked and stunned by her talent and I realized two things: a) I needed to marry her and b) I needed to go into business with her.

In 2007, as we planned our wedding, we realized we couldn’t afford the large NYC wedding we both wanted, so we devised a marketing plan. In July 2007, Carrie and I had an entirely sponsored wedding at a baseball stadium in front of 200 friends and family and 5,000 strangers. We raised $20,000 for charity and $20M in earned media. Everyone was thrilled with the outcome and when our wedding vendors asked us what was next, we thought: “We can’t get married again, so let’s start a company instead.”

While not everyone can start a business with their husband or wife, it really helps to have a truster partner to be #inittogether with. For my second business, for instance, I partnered with my friend of three decades to build our product. Who can you partner with?

2. Create a Strategy and Singular Focus
If you asked me what we did early on in our first business, I’d have told you, ‘What do you need done?” And if you’d asked me how much we charged, I’d have said, “What’s your budget?” While this may have worked early on to help generate revenue, it wasn’t sustainable. Ultimately, too many businesses fail because they don’t have a sound strategy and focus.

I’ve been using Verne Harnish’s one-page strategic plan for both of our businesses. Our management teams meet quarterly to plan the strategy, and believe it or not, thanks to Verne’s tool, we summarize the entire business plan and strategy on just one sheet of paper.

3. Say No to What’s Off Focus

It’s easier to create and plan a strategy and focus than it is to stick to it. But if you’re going to be successful, it’s not just important to say “Yes” to the right things, it’s important to say “No” to the wrong things.

A major turning point in our first business was when we fired Charlie. Charlie was a Greek restaurant owner in Astoria, Queens. A super nice guy, Charlie had us helping promote his restaurant and their special events. But he could only afford to pay us $500 a month — and I knew we couldn’t scale our business if we kept working with people like Charlie. So we fired our own client — and then focused on landing bigger clients who could better help us grow. It’s really hard to say no — but essential, if you’re going to really grow your small business.

4. Find Peer Support

It’s lonely at the top. Seriously, running a business is one the loneliest jobs out there, even if you have a great partner. Nobody really understands what you’re going though. A huge part of our going from $1 million in revenue to $5 million in revenue in three years was my joining Entrepreneurs Organization (EO) in 2010. EO is the world’s largest peer-to-peer network of CEOs, and it’s most important element is monthly meetings with a small group of fellow entrepreneurs called Forum. My Forum of six people has become one of the most important resources in my business and life, my closest friends, and a great support system.

EO isn’t the only game in town though. Here are five great small business peer-to-peer organizations for entrepreneurs to consider, including BNI, Vistage, YPO and YEC.

5. Form a Board of Advisors

You can’t possibly know it all, and even with a great partner and great peers, you can use help in growing your business. While it’s great to have friends and mentors who can help you, I recommend you codify your mentors through the creation of a Board of Advisors.

In 2012, we asked longtime friends and mentors with a wide variety of experience and talent across various focus areas: finance, law, marketing, brand management, and sales. We formed the Likeable Advisory Board and instantly had a group of 11 advisors who we could call on anytime and who met with us formally four times a year to help us grow our business.

We all have friends and mentors with more experience than we have — by forming a Board you can better tap into that experience.

6. Hire Slow. Fire Fast.

“Dave,” said my erstwhile employee of a sales manager I once had, “I don’t care if the guy is putting up big numbers. The guy is doing cocaine in the bathroom with his team.”

When I think back to the biggest mistakes I’ve made as an entrepreneur, they all revolve around hiring the wrong people, or worse yet, keeping the wrong people for longer than they should be around. The employee in the example above, I let go just after that conversation — but it was probably two months after the point at which I should have let him go.

What happens often is, we move too quickly to hire someone and end up hiring the wrong person for the wrong position. Then, even though our intuition tells us we’ve hired the wrong person, we don’t want to accept that fact, so we keep trying to justify the decision, coach that person to success, and/or move him to a new position. This is often more damaging than hiring the wrong person in the first place! The solution? Hire slow, fire fast.

7. Build Great Values and Culture

You and your employees spend more awake time at work than you spend anywhere else, including at home and with your family. So the core values you have and the culture you cultivate at work is absolutely essential to your success and happiness.

We took great care with both of our companies to create core values that would resonate: Amongst them, for Likeable Media: transparency, accountability, and passion; for Likeable Local: obsession for customer success, drive, and continuous improvement. We’ve also worked tirelessly to build culture: retreats out of the office, social events, unique benefits like on-site manicures and massages. The results: Likeable Media has been named to the Crain’s Best Place to Work in NYC for three straight years — and continues to attract the best and brightest people in New York.

8. Build Your Brand

The world of the mobile internet and social media has made it easier than ever before for a small business is “act and look big.” One of our first decisions in business seven years ago was to publish a daily blog. A couple of years later, we had one the most well-read blogs in social media marketing — and that blog didn’t just build our brand — it kept generating lots of leads!

Today, whether it’s on your blog, on Facebook, Twitter or LinkedIn, through online video or pictures, or articles or whitepapers, you have an ability to constantly build your brand — to make your business more credible, more trusted, and more accessible to your customers and prospects. Social media is the great equalizer when it comes to building your brand, and you have a greater opportunity than ever before to make your small business brand BIG!

9. Ask for Referrals

It was late 2011, and we’d hit a wall. New customers weren’t banging down our doorstep, and for the first time ever in business, my wife and I were questioning whether we could continue rapid growth.Then, one of our advisors said, “Have you asked all of your current customers for referrals?”

It seemed so obvious, like so many good ideas after the fact. So we went ahead and asked, and the next thing we knew, we had filled up our pipeline again with strong prospects, that would lead to new closed business and continued rapid growth. The best form of marketing has been and will always be referrals from your current customers, because if you’re doing a good job, they’ll want to help. You won’t have a chance unless you ask.

10. It’s the People, Stupid

Likeable Media and Likeable Local would be absolutely nowhere without our employees, partners, and advisors. Five of the nine steps above involve people. The reality is, your job as an entrepreneur and leader is just three-fold: set the vision and strategy, make sure there’s enough money in the bank to make payroll, and get the right people in the right seats on the bus. The people you hire and fire, partner with or don’t partner with, take advice from or choose not to take advice from — these people will make the difference between success and failure. These people will help you go from 0 to $500K, or 0 to $5 million, or even from 0 to $500 million.

Your people ARE your business. Your people are your future success. Your people are your everything. Now go out there, get some great people together and build that #smallbusiness of your dreams.

Published in collaboration with LinkedIn

Author: Dave Kerpen is the founder and CEO of Likeable Local, a social media software company serving thousands of small businesses, as well as the chairman and cofounder of Likeable Media, an award-winning social media and word-of-mouth marketing agency.

 

 

World's first genetic modification of human embryos reported: Experts consider ethics

 

 

Resultado de imagem para genomics images

The team injected 86 embryos and 71 survived, of which 54 were genetically tested. This revealed that just 28 were successfully spliced, and that only a fraction of those contained the replacement genetic material. Analysis also revealed a number of 'off-target' mutations assumed to be caused by the technique acting in other areas of the genome. The results reveal serious obstacles to using the method in medical applications.

The scientists have tried to head off ethical concerns by using 'non-viable' embryos, which cannot result in a live birth, that were obtained from local fertility clinics. However, the work is very controversial, with some warning it could be the start of a slippery slope towards designer babies.

Below, some experts weigh-in with ethical questions and considerations.

Prof Robin Lovell Badge, Crick Institute, on the science: "The experiments reported by Junjiu Huang and colleagues (Liang et al) in the journal Protein Cell on gene editing in abnormally fertilised human embryos are, I expect, the first of several that we will see this year. There has been much excitement among scientists about the power of these new gene editing methods, and particularly about the CRISPR/Cas9 system, which is relatively simple to use and generally very efficient. The possibility of using such methods to genetically modify human embryos, and therefore humans, has been on the cards since these methods were first described, and recently these prospects have been brought to the attention of the public through several commentaries made by senior scientists and commentators, some of whom have called for a moratorium to halt any attempts."

Dr Yalda Jamshidi, Senior Lecturer in Human Genetics, St George's University Hospital Foundation Trust, said: "Inherited genetic conditions often result because the function of a gene is disrupted. In theory replacing the defective gene with a healthy one would be the ideal solution. This type of treatment is what we call gene therapy and researchers have been working on developing techniques to accomplish this for many years.

"Techniques to correct defective genes in 'non-reproductive' cells are already at various stages of clinical development and promise to be a powerful approach for many human diseases which don't yet have an effective treatment. However, altering genes in human embryos can have unpredictable effects on future generations. Furthermore the study by Huang et al showed that the although the CRISPR/Cas9 technique they used can work in the embryo, it can miss the target in the gene and is too inefficient.

"Future research on the technique may improve the accuracy and efficiency, however scientists still don't fully understand the role of the DNA, and all of its genes. Therefore it is impossible to assess the risks from mis-targeted changes in the DNA sequence, which would affect both the treated embryo and any future generations."

Prof Shirley Hodgson, Professor of Cancer Genetics, St George's University of London, said: "I think that this is a significant departure from currently accepted research practice. This is because any manipulation of the germline of human embryos is potentially heritable. Can we be certain that the embryos that the researchers were working on were indeed non-viable? In the past all the gene therapy research that has been approved by regulatory bodies has been somatic, not germline, because of the potentially unpredictable and heritable effects of germline research. The fact that these researchers found that there were a number of "off target" mutations resulting from the technique they used is clearly a worry in this context. Any proposal to do germline genetic manipulation should be very carefully considered by international regulatory bodies before it should be considered as a serious research prospect. This is because of the obvious concerns about the heritability of the genetic alterations induced, and the way in which such research could spread from work on "non-viable" embryos, to work on viable ones once this type of research had been accepted in principle by international regulatory bodies."

Prof Darren Griffin, Professor of Genetics, University of Kent, said: "Given the widespread use of the CRISPR/Cas9 system, such announcement was inevitable, sooner rather than later. We clearly have a lot of thinking to do. Germline manipulation is currently illegal in the UK but the question is bound to be asked whether this should change, especially if the safety concerns are allayed."

Associate Professor Peter Illingworth is Medical Director at IVFAustralia: "This is a fascinating piece of experimental science. Using abnormally-fertilised human embryos (I.e. With three sets of DNA instead of two), they have studied whether the a human gene can be modified. They have demonstrated that, in some embryos, but not all, they can change the abnormal human gene. They also find that other genes are affected which may be a serious concern. What they have shown is that it is technically possible, not that it is practically feasible or safe."

Further information:

http://www.sciencemediacentre.org/expert-reaction-to-the-application-of-genome-editing-techniques-to-human-embryos/

http://www.smc.org.au/expert-reaction-worlds-first-genetic-modification-of-human-embryos-reported-protein-cell/

Picture this: Graphene brings 3-D holograms clearer and closer

 

 

Resultado de imagem para 3d holograms

From mobile phones and computers to television, cinema and wearable devices, the display of full colour, wide-angle, 3D holographic images is moving ever closer to fruition, thanks to international research featuring Griffith University.

Led by Melbourne's Swinburne University of Technology and including Dr Qin Li, from the Queensland Micro- and Nanotechnology Centre within Griffith's School of Engineering, scientists have capitalised on the exceptional properties of graphene and are confident of applications in fields such as optical data storage, information processing and imaging.

"While there is still work to be done, the prospect is of 3D images seemingly leaping out of the screens, thus promising a total immersion of real and virtual worlds without the need for cumbersome accessories such as 3D glasses," says Dr Li.

First isolated in the laboratory about a decade ago, graphene is pure carbon and one of the thinnest, lightest and strongest materials known to humankind. A supreme conductor of electricity and heat, much has been written about its mechanical, electronic, thermal and optical properties.

"Graphene offers unprecedented prospects for developing flat displaying systems based on the intensity imitation within screens," says Dr Li, who conducted carbon structure analysis for the research.

"Our consortium, which also includes China's Beijing Institute of Technology and Tsinghua University, has shown that patterns of photo-reduced graphene oxide (rGO) that are directly written by laser beam can produce wide-angle and full-colour 3D images.

"This was achieved through the discovery that a single femtosecond (fs) laser pulse can reduce graphene oxide to rGO with a sub-wavelength-scale feature size and significantly differed refractive index.

"Furthermore, the spectrally flat optical index modulation in rGOs enables wavelength-multiplexed holograms for full colour images."

Researchers say the sub-wavelength feature is particularly important because it allows for static holographic 3D images with a wide viewing angle up to 52 degrees.

Such laser-direct writing of sub-wavelength rGO featured in dots and lines could revolutionise capabilities across a range of optical and electronic devices, formats and industry sectors.

"The generation of multi-level modulations in the refractive index of GOs, and which do not require any solvents or post-processing, holds the potential for in-situ fabrication of rGO-based electro-optic devices," says Dr Li.

"The use of graphene also relieves pressure on the world's dwindling supplies of indium, the metallic element that has been commonly used for electronic devices.

"Other technologies are being developed in this area, but rGO looks by far the most promising and most practical, particularly for wearable devices. The prospects are quite thrilling."

The findings are published in the esteemed journal Nature Communications.


Story Source:

The above story is based on materials provided by Griffith University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Xiangping Li, Haoran Ren, Xi Chen, Juan Liu, Qin Li, Chengmingyue Li, Gaolei Xue, Jia Jia, Liangcai Cao, Amit Sahu, Bin Hu, Yongtian Wang, Guofan Jin, Min Gu. Athermally photoreduced graphene oxides for three-dimensional holographic images. Nature Communications, 2015; 6: 6984 DOI: 10.1038/ncomms7984

 

Exercising with arthritis: Improve your joint pain and stiffness

 

 

Exercise helps ease arthritis pain and stiffness

As you consider starting an arthritis exercise program, understand what's within your limits and what level of exercise is likely to give you results.

By Mayo Clinic Staff

Controlling Your Arthritis

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Exercise is crucial for people with arthritis. It increases strength and flexibility, reduces joint pain, and helps combat fatigue. Of course, when stiff and painful joints are already bogging you down, the thought of walking around the block or swimming a few laps might seem overwhelming.

But you don't need to run a marathon or swim as fast as an Olympic competitor to help reduce the symptoms of your arthritis. Even moderate exercise can ease your pain and help you maintain a healthy weight. When arthritis threatens to immobilize you, exercise keeps you moving. Not convinced? Read on.

Why exercise is vital

Exercise can help you improve your health and fitness without hurting your joints. Along with your current treatment program, exercise can:

  • Strengthen the muscles around your joints
  • Help you maintain bone strength
  • Give you more strength and energy to get through the day
  • Make it easier to get a good night's sleep
  • Help you control your weight
  • Make you feel better about yourself and improve your sense of well-being

Though you might think exercise will aggravate your joint pain and stiffness, that's not the case. Lack of exercise actually can make your joints even more painful and stiff. That's because keeping your muscles and surrounding tissue strong is crucial to maintaining support for your bones. Not exercising weakens those supporting muscles, creating more stress on your joints.

Check with your doctor first

Talk to your doctor about how exercise can fit into your current treatment plan. What types of exercises are best for you depends on your type of arthritis and which joints are involved. Your doctor or a physical therapist can work with you to find the best exercise plan to give you the most benefit with the least aggravation of your joint pain.

Exercises for arthritis

Your doctor or physical therapist can recommend exercises that are best for you, which might include range-of-motion exercises, strengthening exercises, aerobic exercise and other activities.

Range-of-motion exercises
These exercises relieve stiffness and increase your ability to move your joints through their full range of motion. Range-of-motion exercises involve moving your joints through their normal range of movement, such as raising your arms over your head or rolling your shoulders forward and backward. These exercises can be done daily or at least every other day.

Strengthening exercises
These exercises help you build strong muscles that help support and protect your joints. Weight training is an example of a strengthening exercise that can help you maintain your current muscle strength or increase it. Do your strengthening exercises every other day — but take an extra day off if your joints are painful or if you notice any swelling.

Aerobic exercise
Aerobic or endurance exercises help with your overall fitness. They can improve your cardiovascular health, help you control your weight and give you more stamina. That way you'll have more energy to get through your day. Examples of low-impact aerobic exercises that are easier on your joints include walking, riding a bike and swimming. Try to work your way up to 20 to 30 minutes of aerobic exercise three times a week. You can split up that time into 10-minute blocks if that's easier on your joints.

Other activities
Any movement, no matter how small, can help. If a particular workout or activity appeals to you, don't hesitate to ask your doctor whether it's right for you. Your doctor might give you the OK to try gentle forms of yoga and tai chi. Tai chi may improve balance and help prevent falls. Be sure to tell your instructor about your condition and avoid positions or movements that can cause pain.

Feb. 14, 2013
References

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Apple Watch: Early impressions

 

 

Gizmag takes a first look at the Apple Watch (Photo: Will Shanklin/Gizmag.com)

Gizmag takes a first look at the Apple Watch (Photo: Will Shanklin/Gizmag.com)

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In case you haven't heard, a smartwatch from a little fruit company in California started shipping today. Gizmag has an Apple Watch in house, along with some early thoughts (very early, mind you, as we're going to take some time before running our full Apple Watch review).

Out of all the big new Apple products from the last 15 years – the iPod, iPhone and iPad – the Apple Watch makes the least striking first impression. Okay, well maybe if you've never used a smartwatch, you'll be blown away from the first moment you see notifications and voice control on your wrist, but we've already been there many times over. There were no "holy shit!" moments after strapping on the Apple Watch.

But that isn't to say this won't be a damn good smartwatch, and potentially a game-changer for wearables. And as the hours pass by in our first day with the Apple Watch, our appreciation has only grown.

The Apple Watch is the smallest color, touchscreen smartwatch we've handled (Photo: Will S...

First, there's an attention to detail here that we haven't yet seen in wearables. The software is a bit more complicated, with a steeper learning curve, than you might expect from Apple, but once you start getting used to the UI and navigation methods, you realize everything is placed very intuitively.

For example, "glances" (quick access cards for individual apps) live below the main clock face, just a swipe away. You check on notifications with a swipe down, just like on smartphones. The Digital Crown button mirrors an iPhone's home button: single tap to go your app home screen, double-tap to jump between your most recent app and the clock face. A long-press summons Siri. A second button below jumps to a list of frequent contacts.

The app screen on the Apple Watch, which you can zoom in and out of by twisting the Digita...

The Digital Crown makes sense. While many smartwatch makers have used faux crowns as buttons, Apple is the first we've seen to let you actually wind it as a navigation tool. Twisting the crown on your main apps screen zooms in and out, so you can get a broader or closer look on the watch's tiny screen. In other areas, it replaces swiping your finger to scroll through a list or longer message.

While on most smartwatches alerts feel like a tiny motor buzzing your wrist, the Apple Watch feels like your wrist is actually being tapped. Little details like this aren't game-changers on their own, but they do add a more human element to the experience.

We're handling the 42 mm space gray Apple Watch Sport with black strap (Photo: Will Shankl...

The build is nice-looking and polished, and keep in mind this is just one of the entry-level Sport versions we're handling. We've seen other spiffy-looking smartwatches, but Apple's real accomplishment here is making it small. Most smartwatches are still fairly bulky, but even this 42 mm Apple Watch is much smaller than any of the Android Wear or Samsung Gear watches.

The entry-level Apple Watch Sport might, at first glance, come off as "the cheap plastic one," but we don't find that to be the case. Want a cheap-feeling plastic band? Pick up the original LG G Watch. This one is far from that: while it has a rubbery feel, it doesn't feel at all flimsy or low-end. If you're put off by the price hike when you jump up to the stainless steel version, then know that you're still getting a very nice watch in the cheaper Sport.

The display looks great – not radically better than the best Android Wear and Samsung Gear displays, but still easily among the best.

As Steve Jobs used to sit on the board of Disney, it shouldn't be too surprising that the ...

There's a lot to learn and explore here, so it may be a little while until we run our full Apple Watch review. In the meantime, though, we can say that it's a strong candidate for the best wearable to date, even if it isn't blowing our minds on Day One the way the original iPhone and first-generation iPad did.

All versions of the Apple Watch are currently backordered, and only sold online at the time being. But you can reserve your place in line to order one, for US$350 or more (the 42 mm Apple Watch Sport handled in this post starts at $400).

Product page: Apple

 

Apple cider vinegar for weight loss

 

 

Drinking apple cider vinegar for weight loss seems far-fetched. Does it work?

Answers from Katherine Zeratsky, R.D., L.D.

Apple cider vinegar isn't likely to be effective for weight loss.

Proponents of the apple cider vinegar diet claim that drinking a small amount of apple cider vinegar before meals or taking an apple cider vinegar supplement helps curb appetite and burn fat. However, there's little scientific support for these claims.

Although occasional use of apple cider vinegar is safe for most people, it won't likely lead to weight loss — and it may pose problems of its own. For example:

  • Apple cider vinegar is highly acidic. It may irritate your throat if you drink it often or in large amounts.
  • Apple cider vinegar may interact with certain supplements or drugs, including diuretics and insulin. This may contribute to low potassium levels.

Remember, there's no magic bullet for weight loss. The key to losing weight is burning more calories than you consume. Choose a variety of healthy foods — such as fruits, vegetables, whole grains and lean sources of protein — and include physical activity in your daily routine.

March 17, 2015

References
  1. Apple cider vinegar. Natural Medicines Comprehensive Database. http://www.naturaldatabase.com. Accessed Feb. 24, 2015.
  2. Bunick CG, et al. Chemical burn from topical apple cider vinegar. Journal of the American Academy of Dermatology. 2012;67:e143.
  3. Forouhar E, et al. Non-traditional therapies for diabetes: Fact or fiction. Journal of Community Hospital Internal Medicine Perspectives. 2012;2:18447.
  4. Salbe AD, et al. Vinegar lacks antiglycemic action on enteral carbohydrate absorption in human subjects. Nutrition Research. 2009;29:846.
  5. Hlebowicz J, et al. The botanical integrity of wheat products influences the gastric distention and satiety in healthy subjects. Nutrition Journal. 2008;7:1.
  6. Nutrition for Everyone. Centers for Disease Control and Prevention. http://www.cdc.gov/nutrition/everyone/basics/foodgroups.html. Accessed Feb. 24, 2015.
  7. Colditz GA. Healthy diet in adults. http://www.uptodate.com/home. Accessed Feb. 24, 2015.

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Electronic cigarettes: A safe way to light up?

 

 

What are electronic cigarettes? Are they safer than conventional cigarettes?

Answers from Lowell Dale, M.D.

Electronic cigarettes, often called e-cigarettes, are battery-operated devices designed to look like regular tobacco cigarettes. Here's how e-cigarettes work: An atomizer heats a liquid containing nicotine, turning it into a vapor that can be inhaled and creating a vapor cloud that resembles cigarette smoke.

Manufacturers claim that electronic cigarettes are a safe alternative to conventional cigarettes. However, the Food and Drug Administration (FDA) has questioned the safety of these products.

When the FDA analyzed samples of two popular brands, it found variable amounts of nicotine and traces of toxic chemicals, including known cancer-causing substances (carcinogens). This prompted the FDA to issue a warning about potential health risks associated with electronic cigarettes.

Until more is known about the potential risks, the safe play is to say no to electronic cigarettes. If you're looking for help to stop smoking, there are many FDA-approved medications that have been shown to be safe and effective for this purpose.

Nov. 25, 2014

References
  1. Yamin CK, et al. E-cigarettes: A rapidly growing Internet phenomenon. Annals of Internal Medicine. 2010;153:607.
  2. FDA and public health officials warn about electronic cigarettes. U.S. Food and Drug Administration. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm173222.htm. Accessed Sept.19, 20114.
  3. Drew AM, et al. Electronic cigarettes: Cautions and concerns. American Family Physician. 2014;90:282.
  4. Electronic cigarettes. U.S. Food and Drug Administration. http://www.fda.gov/NewsEvents/PublicHealthFocus/ucm172906.htm. Accessed Sept. 26, 2014.

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