sexta-feira, 16 de janeiro de 2015

2,500-year-old Pythagoras theorem helps to show when a patient has turned a corner

 

A medical researcher at the University of Warwick has found the 2,500 year-old Pythagoras theorem could be the most effective way to identify the point at which a patient's health begins to improve.

In a paper published in PLOS ONE, Dr Rob Froud from Warwick Medical School at the University of Warwick worked with his colleague Gary Abel from the University of Cambridge. They made the discovery after looking at data from ROC (Receiver Operating Characteristic) curves. These curves were initially developed during World War II for the analysis of signals to help operators decide whether a blip on the screen was an enemy target or allied forces ships or aircrafts. In the 1980s, the curves were adopted by epidemiologists to help them decide at what point an individual has recovered from an illness.

Dr Froud said: "It all comes down to choosing a point on a curve to determine when recovery has occurred. For many chronic conditions, epidemiologists agree that the correct point to choose is that which is closest to the top-left corner of the plot containing the curve. As we stopped to think about it, it struck us as obvious that the way to choose this point was by using Pythagoras theorem."

Pythagoras theorem states that in a right-angled triangle, the sum of the squares of the two right-angled sides is equal to the square of the hypotenuse (i.e the longer diagonal that joins the two right angled sides). This means that one can determine the length of the hypotenuse given the length of the other two sides.

Dr Froud said: "We set about exploring the implications of this and how it might change conclusions in research. We conducted several experiments using real trial data and it seems using Pythagoras' theorem makes a material difference. It helps to identify the point at which a patient has improved with more consistency and accuracy than other methods commonly used.

"The moral of the story is that before you throw out the old stuff in the attic -- just go through it one last time -- as there may be something in there that is still relevant and useful," Dr Froud added.


Story Source:

The above story is based on materials provided by University of Warwick. Note: Materials may be edited for content and length.


Journal Reference:

  1. Robert Froud, Gary Abel. Using ROC Curves to Choose Minimally Important Change Thresholds when Sensitivity and Specificity Are Valued Equally: The Forgotten Lesson of Pythagoras. Theoretical Considerations and an Example Application of Change in Health Status. PLoS ONE, 2014; 9 (12): e114468 DOI: 10.1371/journal.pone.0114468

 

Hands on: Polaroid Socialmatic

 

 

The Instagram logo-inspired Socialmatic from Polaroid

The Instagram logo-inspired Socialmatic from Polaroid

Image Gallery (11 images)

Polaroid has been teasing us with the release of its Socialmatic camera for a while now, and after some delays it is finally shipping. We got our hands on the company's big square Android-based digital camera with built-in zero-ink printer at CES 2015 and can also confirm it actually works as advertised.

At 5.2 in wide, 5.2 in high and 1.2 in thick, the Socialmatic isn't exactly pocketable, but we suppose that's fair since we've never been able to fit a camera and photo printer in a pocket up until this point anyway. (Polaroid also introduced the Zip pocket printer at CES this year.)

Whether or not many people will feel comfortable pulling out the clunky, goofy Instagram logo-inspired device for a few snapshots remains to be seen, but the concept of being able to instantly print 2 by 3-inch photos or stickers or share them via Wi-Fi or Bluetooth will certainly have an appeal to some consumers. Polaroid is banking on the look and its brand name generating some interest among both the retro and social obsessed.

Refilling with zero ink 'Zink' paper is simple

"Polaroid created the original social network; allowing people to instantly share a moment in time with others," said CEO Scott W. Hardy.

Regardless of who, exactly, is the target market for the Socialmatic, it is straightforward and easy to use, with the big 4.5-in touchscreen for framing up shots and a simple process that would allow even an Android rookie to take and print a photo in less than a minute. We had our Socialmatic take this shot of its neighbor from the CES show floor and it printed out with no hassle.

Digital and physical copies

For the more tech savvy, the whole Android ecosystem is also there. You could easily use this device to peruse Facebook and Twitter when you aren't printing out tiny pictures of yourself and your friends. Each Socialmatic photo taken has its own QR code that can be scanned to theoretically (and somewhat creepily) track the history and whereabouts of each print. All this ties back to Polaroid's own social platform, the Socialmatic Photonetwork, as well.

The Socialmatic's main camera is a 14-megapixel shooter, and it also has a 2-MP selfie camera. On board there's 4 GB of storage and a microSD slot, with Polaroid saying the device will ship with Android 4.4 KitKat.

The Socialmatic is shipping now through Photojojo, starting at US$299. Amazon is also taking pre-orders now and will start shipping February 1.

Product page: Polaroid

 

Uma lei ineficaz.

A Indonésia diz ser um país que leva o tráfico de drogas “à sério”. Muitos países levam-no à sério. Mas condenar à morte os infratores não irá resolver de modo algum. O tráfico irá continuar, talvez mais intenso ainda depois da execução dos condenados, entre eles dois brasileiros.
Tudo que é intensamente proíbido é intensamente desejado, e não será esse o caminho para o combate ao uso e ao tráfico de drogas. O tráfico e o uso de drogas ilícitas já tem talvez séculos de história, e até hoje não se desocobriu uma maneira eficaz de pelo menos controlá-lo aos níveis mínimos. No final das contas, os condenados acabam sendo mártires inconsequentes, porque se pelo menos com suas mortes, o problemas fosse atenuado o bastante para justificar seus sacrifícios, eles não teriam morrido em vão.
JS de Melo


Além da AI, várias organizações locais de amparo aos viciados em drogas enviaram uma carta ao presidente indonésio solicitando o cancelamento das execuções.

Um dos que assinaram o documento, o fundador da ONG Fortalecimento e Ação pela Justiça, Rudhy Wedhasmara, disse que a solução para o tráfico de drogas não é a pena de morte, cujas vítimas, disse, são pessoas que estão em uma posição frágil e vulnerável, e não os grandes chefões dos cartéis do narcotráfico.

'O estado não deveria tentar aliviar seu fracasso na política de luta contra o tráfico de drogas com a pena de morte', disse Wedhasmara, segundo o jornal 'Kompas'. EFE



Tumor suppressor protein plays key role in maintaining immune balance

 

A new study from St. Jude Children’s Research Hospital shows that the PTEN tumor suppressor protein is essential for proper regulatory T cell function. The discovery offers new focus for improving treatment of autoimmune diseases. Corresponding author is Hongbo Chi, Ph.D. (on right).

St. Jude Children’s Research Hospital scientists have discovered that a protein widely known for suppressing tumor formation also helps prevent autoimmune diseases and other problems by putting the brakes on the immune response. The research was published recently online ahead of print in the scientific journal Nature Immunology.

Researchers showed that the tumor suppressor protein PTEN is essential for proper functioning of regulatory T cells. This small population of white blood cells helps to maintain immune system balance by suppressing specialized T cells called helper T cells that fuel distinct parts of the immune response. The helper T cells investigated in this study included type 1 T helper (Th1) and follicular T helper (Tfh) cells.

The interplay between regulatory T cells and helper T cells is crucial for both combating infections and for preventing misguided immune attacks that lead to autoimmune diseases and other problems. But details of how regulatory T cells control the diverse functions of various helper T cells have been elusive. This study fills key gaps in that understanding, particularly PTEN’s role. The work also identified a new focus for research to improve treatment of autoimmune diseases.

PTEN is best known as one of the most frequently altered tumor suppressor genes in human cancers, but loss of the protein has also been tied to autoimmune problems. This study showed that is because PTEN is required to maintain the stable population of regulatory T cells that keeps the immune system in check.

“In humans we know that loss of PTEN leads to tumors. This study highlights another role and shows that PTEN is also crucial for proper functioning of regulatory T cells and prevention of autoimmune diseases,” said corresponding author Hongbo Chi, Ph.D., a member of the St. Jude Department of Immunology. “In mice, the loss of just one copy of the PTEN gene in regulatory T cells is sufficient to set the stage for autoimmune problems.”

Working in specially bred mice, researchers showed that deleting the PTEN gene in regulatory T cells was followed by a dramatic increase in the number of Tfh and related cells. Tfh cells aid production of antibodies, which combat infections. But when produced inappropriately, antibodies can also drive autoimmune disorders like lupus. The mice in this study developed kidney damage and immune changes associated with lupus. Restoring PTEN to 50 percent of normal levels did not protect the mice from inflammatory disease.

Researchers found evidence that Th1 cells influence the activity of Tfh cells. Th1 cells produce the chemical messenger interferon gamma that revs up the immune response. When researchers blocked interferon gamma production in the specially bred mice, the number of Tfh cells fell along with lupus-like immune abnormalities.

“We have identified a crucial role of PTEN in controlling Tfh cells and autoantibody production. Additionally, by linking the role of PTEN to Tfh cells, we have opened doors for further investigation of Tfh related lymphomas,” said co-first author Sharad Shrestha, a graduate student in Chi’s laboratory. Added co-first author Kai Yang, Ph.D., a staff scientist in Chi’s laboratory: “These results reveal a hierarchy of control that regulatory T cells use to simultaneously regulate Th1 and Tfh cells. We showed that Th1 production of interferon gamma is a pre-requisite for the activity of Tfh cells.”

The findings also yielded insight into a cell signaling pathway that regulates many important functions, including T cell activity, in response to changing conditions. This is the mTOR pathway, in which the protein complexes mTORC1 and mTORC2 play central roles.

Investigators showed that deletion of PTEN in regulatory T cells led to increased activity of mTORC2 but not mTORC1. When scientists blocked mTORC2 activity in mice whose regulatory T cells lacked PTEN, immune system balance and activity returned to normal. “Our research establishes that the interaction of PTEN and mTORC2 functions as a central pathway to maintain the stability of the regulatory T cell population and to ensure their ability to control the activity of Th1 and Tfh cells,” Chi said. The newly identified PTEN-mTORC2 axis provides another target for efforts to develop better treatments of autoimmune and other disorders.

Protect Your Family from Radon

 

 

Row of houses

Testing is the only way to know if radon levels are high in your home. Read how CDC’s Tracking Programs are improving radon exposure maps to inform testing in their states and find out more information about testing your home for radon.

Tracking Radon Exposure Risks

Radon is a gas that you cannot see, smell, or taste. According to the U.S. Environmental Protection Agency (EPA), radon causes about 20,000 cases of lung cancer each year, making it the second leading cause of lung cancer after smoking. Radon can seep up from the ground and become trapped in buildings. The EPA recommends taking action to reduce radon in buildings that have a radon level at or above 4 picocuries per liter (pCi/L) of air. Testing is the only way to know if radon levels are high in a particular home or office.

CDC funds 26 state and city tracking programs as part of the National Environmental Public Health Tracking Network (Tracking Network). Several tracking programs have worked with national and state partners to improve radon exposure risk maps to better inform radon testing in their states.

Radon Test Results by County, Washington State, 2013. Counties with darker colors have a higher percentage of radon tests that were 4.0pCi/L or greater. Action should be taken when radon test results are 4.0pCi/L or greater.

Tracking Program Improves Washington's Radon Maps

The Washington Tracking Program worked with state geologists to develop a new, more detailed radon exposure risk map for the state. This map identified areas of low, medium, and high risk of radon exposure based on soil and rock types. Tracking staff also gathered state-wide radon testing data from national testing companies as well as data from the state radon program. These data were used to produce maps that showed testing results by ZIP code. Tracking program added radon content to the Washington tracking portal that included maps of radon test data and exposure risk. Layering these maps showed new, previously unknown hot spots, such as around the Puget Sound. It also showed many high to moderate risk areas where no testing had been performed in the past.

Meghan’s step-daughter reading in her bedroom.

Radon Awareness Leads Tracking Employee to Test Her Own Home

Meghan works in the Washington Tracking Program. While helping with the radon mapping project, she realized that the home she and her family recently moved into was in a high-risk area for radon and should be tested. Testing revealed an elevated radon level in the basement room her step-daughter had chosen as her bedroom. Acting on the test results, the family took the simple, recommended steps to mitigate the radon. Adding a fan and keeping the bedroom door open as much as possible to increase air circulation helped to lower the radon level and keep Meghan's family safe.

"I'm so happy we discovered the high radon levels quickly and not after many years of exposing our children to them," said Meghan.

Visit the EPA's radon website to find out more information about testing your home for radon.

Avoid Harmful Substances

 

 

Pregnant woman staying safe at work

In honor of National Birth Defects Prevention Month, make a PACT to get healthy, physically and mentally, before and during pregnancy to increase your chances of having a healthy baby. Avoiding harmful home and workplace exposures is one important step.

Women can lower their risk of having a baby born with a birth defect by following some basic health guidelines throughout their reproductive years. This is important because many birth defects happen very early during pregnancy, sometimes before a woman even knows that she is pregnant. For this year's National Birth Defects Prevention Month, we encourage all women and their loved ones to make a PACT for prevention.

Plan ahead
Avoid harmful substances
Choose a healthy lifestyle
Talk to your healthcare provider

This week, we are focusing on avoiding harmful substances.

Pregnant woman sharing information about her job with her doctor.

Share information about possible hazards at your job with your doctor.

Avoid harmful substances at home or work

Most women can safely keep working in their job during pregnancy. But some jobs involve exposures, like chemical or physical agents, that might be harmful to pregnant or breastfeeding women or that have been linked to birth defects and poor pregnancy outcomes. If you are pregnant or thinking about becoming pregnant, reducing these exposures before and during pregnancy can help increase your chances for having a healthy baby. It is also important to protect your home and family from chemicals that might be brought home by you or other family members from work.

Even if your job involves some hazards, there are things you can do to protect yourself:

For more information about reproductive health and the workplace, visit Reproductive Health and the Workplace.

In addition to avoiding harmful exposures at work, avoiding other substances, like alcohol and smoking, can improve your chances of having a healthy baby.

Avoid drinking alcohol at any time during pregnancy

When a pregnant woman drinks alcohol, so does her baby. Alcohol that's in the woman's blood passes to the baby through the umbilical cord. There is no known safe amount of alcohol use during pregnancy or while trying to get pregnant. There is also no safe time during pregnancy to drink. All types of alcohol are equally harmful, including all wines and beer. Drinking alcohol during pregnancy can cause miscarriage, stillbirth, and a range of lifelong physical, behavioral, and intellectual disabilities. These disabilities are known as fetal alcohol spectrum disorders (FASDs). The best advice is to stop drinking alcohol when you start trying to get pregnant.

Learn more about alcohol and pregnancy »

Avoid smoking

Some of the dangers of smoking during pregnancy include premature birth, stillbirth, and Sudden Infant Death Syndrome (SIDS). In addition, the 2014 Surgeon General's Report confirmed that smoking in early pregnancy can cause orofacial clefts in babies. Orofacial clefts are birth defects that occur very early in pregnancy, so quitting smoking before becoming pregnant is best. Quitting smoking can be hard, but it is one of the best ways you can protect yourself and your baby's health. For more information on smoking in pregnancy and how it can harm you and your baby's heath, visit Tobacco Use and Pregnancy.

CDC Activities: Birth Defects

CDC works to identify causes of birth defects, find opportunities to prevent them, and improve the health of those living with birth defects.

  • Tracking: Accurately tracking birth defects is important for prevention. CDC funds 14 states to track major birth defects using population-based methods. State systems use the data from population-based tracking to help direct birth defects prevention activities and refer children affected by birth defects to needed services.
  • Research: CDC funds the Centers for Birth Defects Research and Prevention, which collaborate on large studies such as the National Birth Defects Prevention Study (births 1997-2011) and the Birth Defects Study To Evaluate Pregnancy exposureS, also called BD-STEPS, (began in 2014). These studies work to identify what might raise or lower the risk of having a baby with a birth defect. Other CDC research focuses on health services use and costs associated with birth defects, which are important considerations in helping children with birth defects reach their full potential.
  • Prevention: CDC and its partners can use what they learn through research to prevent birth defects.
    • Folic acid: We learned long ago that getting folic acid before and during the early weeks of pregnancy greatly reduces the risk of serious birth defects of the brain and spine (e.g., spina bifida and anencephaly). A 1996 policy to add folic acid to many foods helps to prevent many of these birth defects.
    • Preconception care: CDC and its partners also work to educate women about the importance of preconception health through a campaign called Show Your Love.
  • Improving the lives of individuals with birth defects: Babies who have birth defects often need special care and treatments to survive and thrive developmentally. Birth defects tracking systems provide one way to identify and refer children for services they need as early as possible. Early intervention (treatment for delays in physical, intellectual, communication, social-emotional, and adaptive development) is vital to improving outcomes for babies born with a birth defect.

Protect Your Child from Rotavirus Disease

 

 

Photo: Babies

Rotavirus spreads easily among infants and young children, and can cause severe diarrhea. They can get very dehydrated and need to be hospitalized. Protect your child with rotavirus vaccine.

Rotavirus disease is common among infants and young children. Rotavirus can cause severe watery diarrhea, vomiting, fever, and abdominal pain. Some children with rotavirus disease can lose a lot of fluids and become very dehydrated. As a result, they may need to be hospitalized and can even die.

Rotavirus spreads easily among children. The virus passes into the environment through a sick person's stool (poop) and spreads when a child puts something with rotavirus on it, such as their hand or a toy, in their mouth. Children can also get infected by consuming food and liquids that have rotavirus in them. In the United States, children are more likely to get rotavirus from December to June.

Rotavirus Can Cause Dehydration

Symptoms of Dehydration

  • Decrease in urination
  • Dry mouth and throat
  • Feeling dizzy when standing up

A dehydrated child may cry with few or no tears and be unusually sleepy or fussy.

Prevent Dehydration

You can help prevent your child from getting dehydrated by having them drink plenty of liquids. Oral rehydration solutions (ORS) are helpful to prevent and treat dehydration. These are commonly available in food and drug stores. If you are unsure about how to use ORS, call your doctor.

Mother and baby

Children are most likely to get rotavirus disease in the winter and spring (December through June).

Protect your child with rotavirus vaccine

Rotavirus vaccine is the best way to protect your child from rotavirus. Almost all children who get rotavirus vaccine (85 to 98 percent) will be protected from severe rotavirus disease. Most vaccinated children will not get rotavirus disease at all.

There are two different rotavirus vaccines. Both are given by putting vaccine drops in an infant's mouth.

  • Rotateq® - Infants should receive three doses of this vaccine—at 2 months, 4 months, and 6 months of age.
  • Rotarix® - Infants should receive two doses of this vaccine—at 2 months and 4 months of age.

This first dose of either vaccine is most effective if given before a child is 15 weeks old. Children should receive all doses of rotavirus vaccine before they turn 8 months old.

Millions of infants have been vaccinated

Millions of infants in the United States have gotten rotavirus vaccine safely. However, some studies have shown a small increase in cases of intussusception from rotavirus vaccination. Intussusception is a bowel blockage that is treated in a hospital and may require surgery. It is estimated that risk of intussusception is 1 in every 20,000 infants to 1 in every 100,000 infants after vaccination. Intussusception is most likely to happen within the first week after the first or second dose of rotavirus vaccine.​

CDC continues to recommend that infants receive rotavirus vaccine. The benefits of the vaccine far outweigh the small risk of intussusception. Thanks to the rotavirus vaccine, there has been a dramatic decrease in hospitalizations and emergency room visits for rotavirus illness.

Paying for Rotavirus Vaccines

Most health insurance plans cover the cost of vaccines. However, you may want to check with your insurance provider before going to the doctor. If you don't have health insurance or if your insurance does not cover vaccines for your child, the Vaccines for Children (VFC) Program may be able to help. This program helps families of eligible children who might not otherwise have access to vaccines. To find out if your child is eligible, visit the VFC website or ask your child's doctor. You can also contact your state VFC coordinator.

Haptic technology: The next frontier in video games, wearables, virtual reality, and mobile electronics

 

 

The next frontier in human-computer interaction will be all about making you feel the virt...

The next frontier in human-computer interaction will be all about making you feel the virtual, digital world as though it were real and tangible (Photo: David Brohede)

Image Gallery (15 images)

Tactile feedback is nothing new. It's been used in telecommunications and in entertainment for decades, and it became a standard feature in the late 1990s in mobile phones and video games – where vibrations alert you to new messages or help you "feel" the forces exerted on your avatar. Haptic technology has been very much a bit player in the fields that it's infiltrated, though, and only now are we seeing it begin to take its place alongside visual and audio tech as a key element in human-computer interaction.

Smartwatches such as the upcoming Apple Watch are embracing haptics to give you turn-by-turn directions. Researchers, meanwhile, are experimenting with haptic cues built into the steering wheel of cars for enhanced safety, and with tactile feedback built into touchscreens and public maps for more natural-feeling interactions.

Haptics enable deafblind people to browse the web (thanks to Morse Code) or even to play video games. In the gaming space, haptics is a fast-growing field thanks to the rise of virtual reality and the desire of players to feel just as viscerally as they see and hear their virtual environments. Haptic technology is also helping to train the next generation of surgeons, and improving simulations in the industrial sector for pilots and large machine operators.

The basics

Before we get into any of that, let's step back a moment and look at what haptic technology is. In most cases it uses a kind of motor called an actuator to convert electrical, hydraulic or pneumatic energy into vibrations, which can be managed and controlled by software that determines the duration, frequency, and amplitude.

The Nintendo 64 rumble pack introduced a mass gaming audience to the idea of vibrations in...

The Nintendo 64 rumble pack introduced a mass gaming audience to the idea of vibrations in a controller enhancing play (Photo: Evan-Amos)

Smartphones typically use haptic technology for alerts and notifications, as well as for subtle feedback as you type messages or dial numbers on their touchscreens. Video game controllers use haptics now in the same way that they did almost two decades ago with the Nintendo 64 rumble pack and PlayStation DualShock gamepad – to lend a tangibility, felt through your hands gripping the controller, to an explosion or crash or a rough surface that you're driving over.

But there's a lot more that haptics can do, both at the lower resolutions of feedback offered by an Xbox or PlayStation controller (which amounts to little more than an on/off switch with dimmer controls for each of their two actuators) and at the higher resolutions that the latest haptic technology can provide (which allows for feedback localized to specific coordinates and even, at the cutting-edge level, according to how hard you press on the surface).

Haptics look set to be the next big thing in our interactions with the digital world. We can cram surround-sound effects into headphones and record audio at high fidelity with our smartphones, and we can touch and pinch and zoom near everything that appears on a screen. But it all feels flat and lifeless because we've put so little effort into making it anything but that. The human body has a highly-sophisticated capacity for recognizing and responding to textures and vibrations and pokes and all manner of other external forces that engage the receptors in our somatosensory system.

Improving tactile feedback in consumer technology will be crucial as we further our attempts to bridge the divide between all that is physical and tangible and all that is digital and virtual. Among those attempting to explore the possibility space is Mathias Nordvall, a cognitive scientist and game designer at Linköping University in Sweden.

Sightlence and haptic Pong

"A lot of culture today is either vision based or audio based," notes Nordvall. "You go to a concert or you listen to the radio or go to the movies." And if you lack one of those senses, you compensate with the other. Predominately visual interfaces like browsing the web are presented to visually-impaired people through screen readers that speak the text on a page, while TV shows and movies can be watched with closed captions for the hearing impaired.

One day Nordvall wondered: "What happens if you don't have access to either one of them?". How can deafblind people (people with little or no vision and little or no hearing) interact with the modern world? Many of those at the farther end of the deafblind spectrum have never been able to enjoy television, the internet or video games. So Nordvall set out to see if a video game could be made that's "completely and only" based on haptic technology – a game that makes no use of graphics or audio whatsoever.

He sought to do it on the cheap, using only low-cost, off-the-shelf consumer technology, and quickly settled on Xbox 360 controllers, which have two motors in them (and, Nordvall notes, inner workings that are nearly identical to the Nintendo 64 rumble pack released a decade earlier, except for the addition of a second actuator). And after some thought he decided to attempt to translate an existing game, Pong, because that would ensure that any difficulties to play are due to faults in the user interface and not in the game's ruleset.

Two people play haptic Pong (Photo: Xavier V Stamps-Lafont)

The result does not feel at all like Pong, or at least not at first. Players hold one Xbox 360 controller in their hands, with the paddle's movement mapped to one of the joysticks, and they place a second in their lap or somewhere else on their body. Vibrations in each of the controllers indicate where the ball is according to the following rules:

  • The gamepad in your hands will have a steady weak vibration if the ball is above your paddle, a strong vibration if the ball is below, and no vibration if they are at the same height
  • The gamepad in your lap will progressively vibrate faster as the ball moves toward your paddle and slower as it moves away
  • One or the other gamepad will pulse on impact with the walls or paddles, depending on what the ball bounces off

It took my girlfriend and I around half an hour to get the hang of the game, as we started first with the visual and sound aides turned on and then gradually eased our way into haptic-only play. That, Nordvall says, is about standard. "Whenever we test people on it, it's very hard in the beginning," he tells Gizmag. "But after like 20-25 minutes something clicks in your head and you start to realize that 'Oh wait, this signal is actually not at all the same as this other signal that I'm also feeling.' So you can start to tease those out."

In its pure state, haptic Pong features no visual or auditory aides, and a screen that's c...

In its pure state, haptic Pong features no visual or auditory aides, and a screen that's completely blank but for the score (Image: Mathias Nordvall)

Nordvall likens the pulses to a language. "Those pulses that you feel have very little correspondence to a ball bouncing off a paddle or a ball actually coming towards you," he says. "In that sense, it's more about a semantic language; here's an arbitrary signal that means that ball is coming towards you, just like it's arbitrary that we spell 'cat' c-a-t in the English language. But If you write it down on a piece of paper and show it to someone they can understand you."

Video game controllers come associated with a language of play and interaction that gamers have been developing for over 30 years, and people who have played games at any point during that period can learn the language relatively easily. But haptic interfaces don't yet have any kind of standard interface(s), and there hasn't been much experimentation with the idea of creating one. Enter Sightlence.

A screenshot from the beta version of Sightlence, a straightforward haptic editor meant fo...

A screenshot from the beta version of Sightlence, a straightforward haptic editor meant for easy creation of haptic signals to be used in apps and games for any device (Image: Mathias Nordvall)

As an extension of the haptic Pong game, Nordvall and his colleagues have built Sightlence, a haptic editor, which will be available soon and is meant to make it easier for anyone to design haptic output signals for games and other software. Nordvall likens it to a digital audio workstation that's not for creating music but rather for haptics. You have boxes for individual signals, and "samples" that you can create or import and then mix and match, and then you choose where the signal goes – an Xbox gamepad or an Android or iOS device, or perhaps a custom device that you built yourself. The editor is plugin-based, so even if there's no out-of-the-box support for a device, you can write a new plugin driver and jump into the tools.

The idea is that Sightlence will provide the tools for developers to establish a kind of scaffolding for haptic interfaces. "We're not used to using haptic interfaces at all," explains Nordvall. "Especially not for information that's only conveyed through haptics and nothing else."

Haptic growth

Nordvall's haptic editor could help kickstart development of new haptic experiences – of haptic "languages" – where there's currently a big spike in interest on three separate fronts: virtual reality, wearable computing, and touchscreen technology.

The Oculus Rift is helping to drive research and development in haptics as part of a gold ...

The Oculus Rift is helping to drive research and development in haptics as part of a gold rush for total VR immersion

Sightlence may not help much with virtual reality, which leans more toward simulation in one way or another and thus could benefit from direct translation of recorded real-world forces into haptic signals. But wearables and touchscreens will need to be more abstract in their use of the technology, and that appears well-suited to a haptic editor that lets you tap or draw out signals and tweak them to your heart's content.

Apple touts its upcoming Watch as coming with a Taptic Engine that provides tactile sensations on your wrist that are "recognizably different for each kind of interaction." It will, the documentation suggests, allow users to send each other their heartbeats as measured by the heart rate sensor, and perhaps other customized haptic cues. The watch will also guide you in the right direction with a gentle buzz when you're navigating. Other smartwatches and their arrays of apps are trying similar things, and as new kinds of wearables emerge, we're likely to see haptics play a key role in how we interact with the technology we carry around with us.

Especially now that screens, too, are gaining improved haptic technology. Clever techniques such as one involving pushing liquid into prearranged tactile pixels can provide the sensation of pressing physical buttons. Fujitsu last year showed off prototypes for haptic-enhanced tablets that go even farther, offering users a feeling of texture beneath their fingers through ultrasonic vibrations of varying frequencies and amplitudes.

In the virtual reality space, haptic technology could be the missing puzzle piece that propels the likes of Oculus Rift and Sony's Project Morpheus into the mainstream. The trouble is that virtual reality now looks and sounds so lifelike that you instinctively feel like you're physically in the virtual space, and that means that you want to touch things and to feel things touching you. But without haptics (or a whole lot of props and careful planning), neither of these are possible.

That's why there's an arms race in the field. Control VR and PrioVR, among others, track your hands and fingers or entire body in real time, with haptic feedback being gradually explored in most of them.

Others don't worry about motion tracking, and focus only on the haptics. KOR-FX makes you feel every virtual impact – big or small – in your chest, as explosions seem to blow right through you, engines rumble deep beneath your skin, and you feel something akin to the real g-force of your car or spaceship turning.

Others still offer motion-tracked props with built-in haptic feedback, such as with the Striker Virtual Recoil rifle or Tactical Haptics Reactive Grip device.

Immerz's KOR-FX haptic vest lends games and movies a much greater punch, especially when c...

Immerz's KOR-FX haptic vest lends games and movies a much greater punch, especially when coupled with a virtual reality headset

And this is without even getting into the high-cost custom-designed haptic tools used in industrial, medical, and military simulations. Surgeons train or perform remote surgery with 3D glasses and haptic instruments, soldiers get a taste of battle using fake guns with realistic recoil and vests not unlike KOR-FX, while pilots and mining machine technicians also get tactile feedback from their training programs.

A vibrant future

In all of these applications of haptic technology, Nordvall suggests the key is that tactile feedback be used to either augment an experience (to make it feel more real or satisfying, like subtle vibrations on a virtual keyboard or pulses when your virtual car crashes into a wall) or to replace elements of the interface entirely such that the information haptics provide is not available through the soundscape or visually on the screen.

In a video game, for instance, "you could have some vibration telling you which way is north, so that you don't have to look at a mini-map all the time," says Nordvall. Neither method has been explored fully, and the latter especially is ripe for attention. You could have experiences that are only possible with haptics, Nordvall suggests, or reinvent existing ones, like the game of Pong or perhaps navigating through a maze.

With recent research producing both new forms of haptic feedback (just last month Gizmag reported on holographic objects that can be seen and felt) as well as more sophisticated tactile displays and 3D maps, the future of haptics seems limited only by our imaginations. The technology is maturing rapidly, and it's making its way into the mass market on a scale worthy of developer attention. Now the interfaces that apply it need to catch up.

 

Environment, not genes, dictates human immune variation, study finds

 

 

Mark Davis and his colleagues have discovered that our environment, not our genes, play a greater factor in shaping the human immune system.

A study of twins conducted by Stanford University School of Medicine investigators shows that our environment, more than our heredity, plays the starring role in determining the state of our immune system, the body's primary defense against disease. This is especially true as we age, the study indicates.

Much has been made of the role genes play in human health. Stunning advances in gene-sequencing technologies, in concert with their plummeting costs, have turned many scientists' attention to minute variations in the genome -- the entire toolbox of genes carried in virtually every cell in the body -- in the hope of predicting people's future health. Such studies have revealed a genetic contribution to health outcomes. But, with some notable exceptions, very few individual genetic variants contribute much to particular health conditions.

"The idea in some circles has been that if you sequence someone's genome, you can tell what diseases they're going have 50 years later," said Mark Davis, PhD, professor of microbiology and immunology and director of Stanford's Institute for Immunity, Transplantation and Infection. But while genomic variation clearly plays a key role in some diseases, he said, the immune system has to be tremendously adaptable in order to cope with unpredictable episodes of infection, injury and tumor formation.

"The immune system has to think on its feet," said Davis, senior author of the new study, which will be published Jan. 15 in Cell. Lead authorship is shared by former Stanford postdoctoral scholars Petter Brodin, MD, PhD, and Vladimir Jojic, PhD.

Nature versus nurture

"Unlike inbred lab mice, people have broadly divergent genetic heritages," said Davis, who is also the Burt and Marion Avery Family Professor. "And when you examine people's immune systems, you often find tremendous differences between them. So we wondered whether this reflects underlying genetic differences or something else. But what we found was that in most cases, including the reaction to a standard influenza vaccine and other types of immune responsiveness, there is little or no genetic influence at work, and most likely the environment and your exposure to innumerable microbes is the major driver."

To determine nature's and nurture's relative contributions, Davis and his colleagues turned to a century-old method of teasing apart environmental and hereditary influences: They compared pairs of monozygotic twins -- best known to most of us as "identical" -- and of dizygotic, or fraternal, twins. Monozygotic twins inherit the same genome. Despite inevitable copying errors when cells divide, which cause tiny genetic divergences to accumulate between monozygotic twins over time, they remain almost 100 percent genetically identical. Dizygotic twins are no more alike genetically than regular siblings, on average sharing 50 percent of their genes.

Because both types of twins share the same environment in utero and usually share the same environment in childhood, they make excellent subjects for contrasting hereditary versus environmental influence.

About two decades ago, study co-author Gary Swan, PhD, who was then at SRI Inc. and is now a consulting professor of medicine at Stanford, began curating a registry of twins for research purposes. The registry now includes about 2,000 twin pairs. For the new study, the researchers recruited 78 monozygotic-twin pairs and 27 pairs of dizygotic twins from the registry. They drew blood from both members of each twin pair on three separate visits.

The Stanford team then applied sophisticated laboratory methods to the blood samples to measure more than 200 distinct immune-system components and activities. All samples were sent immediately to Stanford's Human Immune Monitoring Core, which houses the latest immune-sleuthing technology under a single roof.

The power of environment

Examining differences in the levels and activity states of these components within pairs of monozygotic and dizygotic twins, the Stanford scientists found that in three-quarters of the measurements, nonheritable influences -- such as previous microbial or toxic exposures, vaccinations, diet and dental hygiene -- trumped heritable ones when it came to accounting for differences within a pair of twins. This environmental dominance was more pronounced in older identical twins (age 60 and up) than in younger twins (under age 20).

Davis and his associates also observed considerable environmental influence over the quantities of antibodies produced in members of twin pairs who had been vaccinated for influenza in a separate Stanford investigation directed by study co-author Cornelia Dekker, MD, professor of pediatric infectious disease and medical director of the Stanford-Lucile Packard Children's Hospital Vaccine Program. While many previous studies have suggested a powerful genetic component in vaccine responsiveness, Davis noted that those studies typically were performed in very young children who had not yet undergone the decades of environmental exposure that appears to reshape the immune system over time.

In a striking example of the immune system's plasticity, the Stanford scientists found that the presence or absence of a single chronic viral infection could have a massive effect on the system's composition and responsiveness. Three out of five people in the USA and as many as nine out of 10 people in the developing world are chronic carriers of cytomegalovirus, which is dangerous in immune-compromised people but otherwise generally benign. In 16 of the 27 monozygotic twin pairs participating in the study, one member of the pair had been exposed to cytomegalovirus but the other had not. For nearly 60 percent of all the features Davis' group measured, cytomegalovirus' presence in one twin and absence in another made a big difference.

"Nonheritable influences, particularly microbes, seem to play a huge role in driving immune variation," said Davis. "At least for the first 20 or so years of your life, when your immune system is maturing, this amazing system appears able to adapt to wildly different environmental conditions. A healthy human immune system continually adapts to its encounters with hostile pathogens, friendly gut microbes, nutritional components and more, overshadowing the influences of most heritable factors."

Eczema woes not just skin deep

 

Eczema wreaks havoc on its sufferers' lives with health problems that are more than skin deep. Adults who have eczema -- a chronic itchy skin disease that often starts in childhood -- have higher rates of smoking, drinking alcoholic beverages and obesity and are less likely to exercise than adults who don't have the disease, reports a new Northwestern Medicine® study.

These behaviors give them a higher risk of cardiovascular disease, including high blood pressure and high cholesterol as well as diabetes. They also have higher rates of insomnia.

"This disease takes a huge emotional toll on its sufferers, like chronic pain," said lead study author Dr. Jonathan Silverberg. "Because eczema often starts in early childhood, people are affected all through their developmental years and adolescence. It hurts their self-esteem and identity. That's part of why we see all these negative behaviors."

Silverberg is an assistant professor of dermatology at Northwestern University Feinberg School of Medicine and a dermatologist at Northwestern Memorial Hospital. He also is director of the Northwestern Medicine Multidisciplinary Eczema Center.

Adding to eczema patients' health woes is difficulty exercising, because sweat and heat aggravate the itching. "They will avoid anything that triggers the itch," Silverberg said. "Patients report their eczema flares during a workout."

The study was published Jan. 8 in the Journal of Allergy and Clinical Immunology.

"This opens our eyes in the world of dermatology that we're not just treating chronic inflammation of the skin but the behavioral, lifestyle side of things," Silverberg said. Dermatologists need to ask patients about their lifestyle habits such as smoking and physical activity so they can offer interventions.

The study analyzed data for 27,157 and 34,525 adults aged 18 to 85 years from the 2010 and 2012 National Health Interview Survey. The Northwestern study reported patients with eczema had 54 percent higher odds of being morbidly obese, 48 percent higher odds of hypertension, up to 93 percent higher odds of having pre-diabetes and up to 42 percent higher odds of having diabetes. They also had 36 percent higher odds of high cholesterol.

Silverberg said patients should be offered interventions for alcohol and smoking by their dermatologists. In addition, he is collaborating with colleagues in Northwestern's department of physical therapy and human movement sciences to figure out how patients with eczema can exercise to improve their health without worsening their skin flare-ups.


Story Source:

The above story is based on materials provided by Northwestern University. The original article was written by Marla Paul. Note: Materials may be edited for content and length.


Journal Reference:

  1. Jonathan I. Silverberg, Philip Greenland. Eczema and cardiovascular risk factors in 2 US adult population studies. Journal of Allergy and Clinical Immunology, 2015; DOI: 10.1016/j.jaci.2014.11.023

 

Inventors choose to reveal their secret sauce before patent approval

 

January 15, 2015

Georgia Institute of Technology

Common wisdom and prior economic research suggest that an inventor filing a patent would want to keep the technical know-how secret as long as possible. But a new study of nearly 2 million patents shows that inventors are not as concerned with secrecy as previously thought. Researchers found that since 2000, most inventors when given the choice opted to disclose information about their patents before patent approval -- even small inventors -- and this disclosure correlates with more valuable patents.


Common wisdom and prior economic research suggest that an inventor filing a patent would want to keep the technical know-how secret as long as possible. But a new study of nearly 2 million patents shows that inventors are not as concerned with secrecy as previously thought. Researchers found that since 2000, most inventors when given the choice opted to disclose information about their patents before patent approval -- even small inventors -- and this disclosure correlates with more valuable patents.

"Do inventors really value the secrecy that economists assumed they did based on the prior literature? Our findings are that overwhelmingly, and in every category that we can test, inventors don't," said Stuart Graham, study co-author and assistant professor at the Georgia Institute of Technology's Scheller College of Business. Graham was the first-ever chief economist appointed at the U.S. Patent and Trademark Office (USPTO), serving in the U.S. Department of Commerce while on leave from Georgia Tech from 2010 to 2013.

The study, co-authored with Deepak Hegde (New York University), will be published January 16 in the journal Science, and was sponsored in part by the Ewing Marion Kauffman Foundation.

During the congressional debate over the AIPA, prominent inventors raised concerns that reduced secrecy would harm not only small inventors, but undermine the inventive spirit throughout the world. So a loophole was included in the AIPA, allowing inventors to maintain secrecy of their patent applications if they were not also filing for parallel foreign patent protection on the same invention.

The change in the law created an opportunity for Graham and his colleague Deepak Hegde, an assistant professor of management and organizations at NYU's Stern School of Business, to examine which inventors were choosing to opt into the secrecy loophole, and whether their patents differed in important ways. They examined 1.8 million granted patents filed at the USPTO from 1995 to 2005 and analyzed the disclosure preferences of the inventors. Their analysis found that, among those not seeking foreign protection, about 85 percent of inventors filing a patent since 2000 chose to disclose information about their patents prior to their approval.

"Overwhelmingly, those inventors patenting only in the U.S. are choosing 18 month disclosure," co-author Hegde said.

The patents examined in the study are called utility patents, which are available on new and useful processes, machines, manufactured articles, or compositions, and protect technologies like software, laptops, medical devices, and drugs. These are the commonest type of patent with more than 570,000 filed at the USPTO in 2013, each containing technical information.

When the AIPA was passed, one of the biggest complaints was that the publication requirement would hurt U.S. small inventors, but the researchers found that individuals and small companies still opted for disclosure during the study period.

"Small U.S. inventors are not choosing the secrecy route," Graham said. "When they patent only in the U.S., they are choosing secrecy in only about 15 percent of the cases, not statistically different than the rate among all other types of inventors."

Another major complaint of the AIPA was that disclosing patent secrets would stop the engine of innovation in the United States and that society would get less meaningful inventions. Contrary to these arguments, the researchers found that patents born out of secrecy were overall less valuable than those that opted for disclosure.

"When we examine indicators of patent value, we find consistent evidence that the least-valuable and least-impactful patents are those that opted for pre-grant secrecy," Hegde said.

The authors point out that more patent information, provided to society earlier, could be socially beneficial. Publishing patent information earlier may provide a head start for other innovators, and may help society avoid unnecessary duplicative research spending, the researchers said.

"We have limited resources in our society that we can invest in innovation and invention," Graham said. "To the extent that we can more efficiently choose projects and avoid wasteful, redundant efforts, then that's good for us as a society."

Future work will involve pinpointing why inventors are choosing not to keep their patent information secret until grant. Some possible answers are that disclosure acts as an early signal to competitors to not innovate in that technology space, or announces to potential licensees that a technology is coming to the marketplace and may be available as an input for someone else's manufacturing or engineering process.

"This study is a first window into what inventors are really doing. The next question is why are they doing it?" Graham said. "It remains for us to figure out why inventors seeking to maximize the value of their inventions are not particularly interested in pre-patent secrecy."


Story Source:

The above story is based on materials provided by Georgia Institute of Technology. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. Graham, D. Hegde. Disclosing patents' secrets. Science, 2015; 347 (6219): 236 DOI: 10.1126/science.1262080