New anticancer compound discovered

 

May 21, 2014

VTT Technical Research Centre of Finland

A previously unknown Cent-1 molecule that kills cancer cells has been discovered by scientists. The objective of the research was to accelerate the drug development process by identifying new compounds that would possess similar binding properties and cellular phenotype, but a different chemical structure, as the selected drugs in clinical use or investigational compounds in development. The scientists combined computer-based screening and cell-based assays to create a method that can significantly accelerate drug discovery and thereby lower development costs.

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A team of research scientists from VTT Technical Research Centre of Finland, the University of Turku and the University of Eastern Finland has discovered a previously unknown Cent-1 molecule that kills cancer cells. Their research also shows that new cancer drug candidates can be identified faster and at lower cost by using computer-assisted and cell-based screening of compounds.

The objective of the research project led by Marko Kallio, Principal Scientist at VTT, was to accelerate the drug development process by identifying new compounds that would possess similar binding properties and cellular phenotype , but a different chemical structure, as the selected drugs in clinical use or investigational compounds in development.

The scientists combined computer-based screening and cell-based assays to create a method that can significantly accelerate drug discovery and thereby lower development costs. It is highly likely that the new compounds identified using this method have not yet been patented.

The research team conducted a computer-assisted screening of 65,000 compounds and cell-based assays on the 150 highest scoring hit compounds, before identifying the Cent-1 molecule. The Cent-1 molecule kills cancer cells through a mechanism similar to that of the template drug Rigosertib that is currently under commercial development. However, since the chemical structure of the Cent-1 compound differs from Rigosertib, there are no major obstacles to further development.

What makes the study also significant is evidence that Rigosertib did not inhibit its reported target genes; there is reason to believe that the drug has a different mechanism of action at molecular level than anticipated. This drug discovery related study was published in the Molecular Cancer Therapeutics in April 2014.

Development of new drugs is an expensive and time-consuming process. It usually takes around 10-15 years to complete and costs several hundreds of millions of euros. In addition, risks associated with the usability, therapeutic efficacy and market share of medicinal substances are usually realized only in the final stages of drug development.

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Story Source:

The above story is based on materials provided by VTT Technical Research Centre of Finland. Note: Materials may be edited for content and length.

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Journal Reference:

1. J. H. E. Maki-Jouppila, L. J. Laine, J. Rehnberg, E. Narvi, P. Tiikkainen, E. Hukasova, P. Halonen, A. Lindqvist, L. Kallio, A. Poso, M. J. Kallio. Centmitor-1, a Novel Acridinyl-Acetohydrazide, Possesses Similar Molecular Interaction Field and Antimitotic Cellular Phenotype as Rigosertib, ON 01910.Na. Molecular Cancer Therapeutics, 2014; 13 (5): 1054 DOI: 10.1158/1535-7163.MCT-13-0685