domingo, 19 de abril de 2015

China’s thriving export industry comes with a high cost

 

Fri, 04/17/2015 - 8:35am

American Chemical Society

China has become the world’s largest exporter, leading to the country’s rapid economic development—and notorious pollution that’s harmful to human health. For the first time, scientists have estimated this trend’s health cost. They report in Environmental Science & Technology that in 2007, export-related emissions in China led to almost 160,000 deaths.

Qiang Zhang and colleagues note that Chinese exports have increased at an annual rate of about 20% over the past 10 years. This fast clip has boosted the economy but is also contributing significantly to air pollutant emissions. These emissions lead to increases in concentrations of fine particulate matter, which has been linked to cardiovascular and respiratory problems and related deaths. Some research has provided information to help estimate how much the export industry is contributing to air pollution, but so far, no work has measured the health effects. Zhang’s team decided to fill that gap.

The researchers calculated that China’s export-related emissions in 2007 caused 157,000 deaths. That accounted for 12% of the overall mortality due to fine particulate matter in the country. They also noticed geographic and economic disparities. Health problems experienced by people in the central, northern and western regions of the country (where heavy, emissions-intensive industries are concentrated) were disproportionately high compared to the economic benefits. Based on their findings, the researchers recommend several policy measures, such as updating technology to reduce harmful pollutants from industry.

Source: American Chemical Society

GE announces first FAA approved 3D-printed engine part

 

The T25 housing is located inlet to the high-pressure compressor and protects the sensor e...

The T25 housing is located inlet to the high-pressure compressor and protects the sensor electronics (Photo: GE Aviation)

We've only just begun to see the huge impact 3D-printing technology will have on manufacturing, and the aerospace industry is a prime example. Earlier this year we saw the first example of a 3D-printed jet engine, now GE has announced the first 3D-printed part certified by the US Federal Aviation Administration (FAA) for a commercial jet engine. The fist-sized T25 housing for a compressor inlet temperature sensor for a jet engine was fabricated by GE Aviation and will be retrofitted to over 400 GE90-94B jet engines on Boeing 777 aircraft.

The T25 housing is located inlet to the high-pressure compressor and protects the sensor electronics from cold and being buffeted by airflow, and is the product of a decade's experimentation in additive manufacturing. In this, the usual fabrication methods of casting or milling metal are replaced by building up a part layer by layer guided directly from a CAD file like a hobbyist's 3D printer.

The difference is that instead of making an item by adding layers of molten plastic, the T25 housing is made of a fine powder of cobalt-chrome alloy. This is spread out in a flat layer and a laser or electron beam fuses a section of the CAD plan in it. Another layer of dust is laid down and the process is repeated. When the printing is completed, the excess powder is blown and brushed away, and the part is given a finish.

The 3 printer shoots a laser or electron beam into a thin layer of cobalt-chrome powder to...

This method has a number of advantages. The part can be made lighter and extremely complex shapes can be made in a single piece, instead of several fitted together. This allows for designs that were previously impossible, much faster turnaround times from design to finished product, and much lower manufacturing costs with very little waste.

According to GE, making a prototype of the T25 would have taken a year longer using conventional methods.

The T25 sensor housing is the first 3D-printed part certified by the FAA for a commercial ...

Though the T25 is the first 3D-printed part to go into service, it won't be the last. GE says that the next-generation LEAP jet engine currently being flight tested will include 19 3D-printed fuel nozzles. In addition, 3D-printed fuel nozzles and other parts are also under development for the GE9X engine for Boeing’s new 777X aircraft; the largest jet engine ever built. The new engines' development also includes ceramic matrix composites (CMCs) and carbon-fiber fan blades.

"The 3D printer allowed us to rapidly prototype the part, find the best design and move it quickly to production," says Bill Millhaem, general manager for the GE90 and GE9X engine programs at GE Aviation. "We got the final design last October, started production, got it FAA certified in February, and will enter service next week. We could never do this using the traditional casting process, which is how the housing is typically made."

Source: GE

 

Devices or divisive: Mobile technology in the classroom

 

Resultado de imagem para educational technology

 

 

Little is known about how new mobile technologies affect students' development of non-cognitive skills such as empathy, self-control, problem solving, and teamwork. Two Boston College researchers say it's time to find out.

Boston College Lynch School of Education Assistant Professor Vincent Cho and BC Graduate Research Assistant Joshua Littenberg-Tobias present a new survey measuring teachers' perspectives on these issues today at the American Educational Research Association annual meeting session "Examining the Potential of Mobile Technology."

"Schools see digital devices -- smart phones, tablets and laptops -- as a way to propel innovation, but we haven't effectively asked teachers about the impact of these technologies on students' social, emotional and personal development," said Cho. "Furthermore, teacher attitudes are crucial to the success of high-tech initiatives. Teachers are the people who will revolutionize schools. Technology is just a starting point. We should know what teachers think."

Schools around the world spent $13 billion -- including $4 billion in the U.S. -- on K-12 classroom technology in 2013 and total spending is slated to grow to $19 billion by 2018, according to Futuresource Consulting.

Cho and Littenberg-Tobias have designed a survey tool to measure views on the effects of digital technology. The researchers surveyed 59 educators at a "1:1" Catholic high school where each student is required to bring a smart phone, iPad or laptop.

They found that teachers' views could be grouped into three areas: how mobile technology can be used to improve "whole student" outcomes, the impact of these new technologies on classroom learning, and the impact of "digital distraction." Although teachers were mostly positive about the impact of technology on classroom learning, they also had concerns about the impact of mobile technologies on students' non-cognitive skills, such as empathy, self-control, problem solving and teamwork.

"Teachers are the ones implementing these new technologies," said Littenberg-Tobias. "They are the eyes and ears on the ground and they see the impact of these technologies on a day-to-day basis."


Story Source:

The above story is based on materials provided by Boston College. Note: Materials may be edited for content and length.


 

Exercise protects the heart via nitric oxide, researchers discover

 

 

Resultado de imagem para Estilo de vida saudável - imagens

May 5, 2011

Emory University

Exercise both reduces the risk of a heart attack and protects the heart from injury if a heart attack does occur. For years, doctors have been trying to dissect how this second benefit of exercise works, with the aim of finding ways to protect the heart after a heart attack. Researchers have identified the ability of the heart to produce and store nitric oxide as an important way in which exercise protects the heart from injury.


Exercise both reduces the risk of a heart attack and protects the heart from injury if a heart attack does occur. For years, doctors have been trying to dissect how this second benefit of exercise works, with the aim of finding ways to protect the heart after a heart attack.

Researchers at Emory University School of Medicine have identified the ability of the heart to produce and store nitric oxide as an important way exercise protects the heart from injury.

Nitric oxide, a short-lived gas generated within the body, turns on chemical pathways that relax blood vessels to increase blood flow and activate survival pathways. Both the chemical nitrite and nitrosothiols, where nitric oxide is attached to proteins via sulfur, appear to act as convertible reservoirs for nitric oxide in situations where the body needs it, such as a lack of blood flow or oxygen.

The Emory team's results, published online in the journal Circulation Research, strengthen the case for nitrite and nitrosothiols as possible protectants from the damage of a heart attack.

The first author is John Calvert, PhD, assistant professor of surgery at Emory University School of Medicine. The senior author is David Lefer, PhD, professor of surgery at Emory University School of Medicine and director of the Cardiothoracic Research Laboratory at Emory University Hospital Midtown. Collaborators included scientists at University of Colorado, Boulder, and Johns Hopkins University.

"Our study provides new evidence that nitric oxide generated during physical exercise is actually stored in the bloodstream and heart in the form of nitrite and nitrosothiols. These more stable nitric oxide intermediates appear to be critical for the cardioprotection against a subsequent heart attack," Lefer says.

Timing is key -- the benefits of exercise don't last In experiments with mice, the researchers showed that four weeks of being able to run on a wheel protected them from having a coronary artery was blocked; the amount of heart muscle damaged by the blockage was less after the exercise period. Importantly, the mice are still protected a week after the wheel is taken away.

The researchers found that voluntary exercise boosted levels of an enzyme that produces nitric oxide (eNOS, endothelial nitric oxide synthase). Moreover, the levels of eNOS in heart tissue, and nitrite and nitrosothiols in the blood as well as heart tissue, stayed high for a week after exercise ceased, unlike other heart enzymes stimulated by exercise. The protective effects of exercise did not extend beyond four weeks after the exercise period was over, when nitrite and nitrosothiols in the heart returned to baseline.

In mice that lack the eNOS enzyme, exercise did not protect the heart from a coronary blockage, although these mice appeared to lack the ability to exercise as much as normal mice.

Another molecule that appears to be important for the benefits of exercise is the beta-3-adrenergic receptor, which allows cells to respond to the hormones epinephrine and norepinephrine. All of the beneficial effects of voluntary exercise are lost in mice that are deficient in this receptor. One of the effects of stimulating the receptor appears to be activating eNOS. Additional animal studies are currently underway in Lefer's lab to determine the potential benefit of beta-3-adrenergic receptor activating drugs following a heart attack.

The research was supported by the American Diabetes Association, the National Institutes of Health and the Carlyle Fraser Heart Center of Emory University Hospital Midtown.


Story Source:

The above story is based on materials provided by Emory University. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. W. Calvert, M. Elston, J. Pablo Aragon, C. K. Nicholson, B. F. Moody, R. L. Hood, A. Sindler, S. Gundewar, D. R. Seals, L. A. Barouch, D. J. Lefer. Exercise Protects Against Myocardial Ischemia-Reperfusion Injury via Stimulation of β3-Adrenergic Receptors and Increased Nitric Oxide Signaling: Role of Nitrite and Nitrosothiols. Circulation Research, 2011; DOI: 10.1161/CIRCRESAHA.111.241117

 

Heart disease prevention: Strategies keep your heart healthy, thus preventing heart disease.

 

 

Resultado de imagem para Estilo de vida saudável - imagens

 

You can prevent heart disease by following a heart-healthy lifestyle. Here are strategies to help you protect your heart.

By Mayo Clinic Staff

Heart-Healthy Living

Heart disease may be a leading cause of death, but that doesn't mean you have to accept it as your fate. Although you lack the power to change some risk factors — such as family history, sex or age — there are some key heart disease prevention steps you can take.

You can avoid heart problems in the future by adopting a healthy lifestyle today. Here are six heart disease prevention tips to get you started.

1. Don't smoke or use tobacco

Smoking or using tobacco of any kind is one of the most significant risk factors for developing heart disease. Chemicals in tobacco can damage your heart and blood vessels, leading to narrowing of the arteries (atherosclerosis). Atherosclerosis can ultimately lead to a heart attack.

Carbon monoxide in cigarette smoke replaces some of the oxygen in your blood. This increases your blood pressure and heart rate by forcing your heart to work harder to supply enough oxygen. Women who smoke and take birth control pills are at greater risk of having a heart attack or stroke than are those who don't do either because both smoking and taking birth control pills increase the risk of blood clots.

When it comes to heart disease prevention, no amount of smoking is safe. But, the more you smoke, the greater your risk. Smokeless tobacco and low-tar and low-nicotine cigarettes also are risky, as is exposure to secondhand smoke. Even so-called "social smoking" — smoking only while at a bar or restaurant with friends — is dangerous and increases the risk of heart disease.

The good news, though, is that when you quit smoking, your risk of heart disease drops almost to that of a nonsmoker in about five years. And no matter how long or how much you smoked, you'll start reaping rewards as soon as you quit.

2. Exercise for 30 minutes on most days of the week

Getting some regular, daily exercise can reduce your risk of fatal heart disease. And when you combine physical activity with other lifestyle measures, such as maintaining a healthy weight, the payoff is even greater.

Physical activity helps you control your weight and can reduce your chances of developing other conditions that may put a strain on your heart, such as high blood pressure, high cholesterol and diabetes.

Try getting at least 30 to 60 minutes of moderately intense physical activity most days of the week. However, even shorter amounts of exercise offer heart benefits, so if you can't meet those guidelines, don't give up. You can even get the same health benefits if you break up your workout time into three 10-minute sessions most days of the week.

And remember that activities, such as gardening, housekeeping, taking the stairs and walking the dog all count toward your total. You don't have to exercise strenuously to achieve benefits, but you can see bigger benefits by increasing the intensity, duration and frequency of your workouts.

3. Eat a heart-healthy diet

Eating a healthy diet can reduce your risk of heart disease. Two examples of heart-healthy food plans include the Dietary Approaches to Stop Hypertension (DASH) eating plan and the Mediterranean diet.

A diet rich in fruits, vegetables and whole grains can help protect your heart. Beans, other low-fat sources of protein and certain types of fish also can reduce your risk of heart disease.

Limiting certain fats you eat also is important. Of the types of fat — saturated, polyunsaturated, monounsaturated and trans fat — saturated fat and trans fat are the ones to try to limit or avoid. Try to keep saturated fat to no more than 10 percent of your daily calories. And, try to keep trans fat out of your diet altogether.

Major sources of saturated fat include:

  • Red meat
  • Dairy products
  • Coconut and palm oils

Sources of trans fat include:

  • Deep-fried fast foods
  • Bakery products
  • Packaged snack foods
  • Margarines
  • Crackers

If the nutrition label has the term "partially hydrogenated," it means that product contains trans fat.

Heart-healthy eating isn't all about cutting back, though. Healthy fats from plant-based sources, such as avocado, nuts, olives and olive oil, help your heart by lowering the bad type of cholesterol.

Most people need to add more fruits and vegetables to their diet — with a goal of five to 10 servings a day. Eating that many fruits and vegetables can not only help prevent heart disease but also may help prevent cancer and improve diabetes.

Eating several servings a week of certain fish, such as salmon and mackerel, may decrease your risk of heart attack.

Following a heart-healthy diet also means keeping an eye on how much alcohol you drink. If you choose to drink alcohol, it's better for your heart to do so in moderation. For healthy adults, that means up to one drink a day for women of all ages and men older than age 65, and up to two drinks a day for men age 65 and younger. At that moderate level, alcohol can have a protective effect on your heart. More than that becomes a health hazard.

4. Maintain a healthy weight

Being overweight, especially if you carry excess weight around your middle, ups your risk of heart disease. Excess weight can lead to conditions that increase your chances of heart disease — high blood pressure, high cholesterol and diabetes.

One way to see if your weight is healthy is to calculate your body mass index (BMI), which considers your height and weight in determining whether you have a healthy or unhealthy percentage of body fat. BMI numbers 25 and higher are associated with higher blood fats, higher blood pressure, and an increased risk of heart disease and stroke.

The BMI is a good, but imperfect guide. Muscle weighs more than fat, for instance, and women and men who are very muscular and physically fit can have high BMIs without added health risks. Because of that, waist circumference also is a useful tool to measure how much abdominal fat you have:

  • Men are considered overweight if their waist measurement is greater than 40 inches (101.6 centimeters, or cm).
  • Women are overweight if their waist measurement is greater than 35 inches (88.9 cm).

Even a small weight loss can be beneficial. Reducing your weight by just 5 to 10 percent can help decrease your blood pressure, lower your blood cholesterol level and reduce your risk of diabetes.

5. Get enough quality sleep

Sleep deprivation can do more than leave you yawning throughout the day; it can harm your health. People who don't get enough sleep have a higher risk of obesity, high blood pressure, heart attack, diabetes and depression.

Most adults need seven to nine hours of sleep each night. If you wake up without your alarm clock and you feel refreshed, you're getting enough sleep. But, if you're constantly reaching for the snooze button and it's a struggle to get out of bed, you need more sleep each night.

Make sleep a priority in your life. Set a sleep schedule and stick to it by going to bed and waking up at the same times each day. Keep your bedroom dark and quiet, so it's easier to sleep.

If you feel like you've been getting enough sleep, but you're still tired throughout the day, ask your doctor if you need to be evaluated for sleep apnea. Obstructive sleep apnea blocks the airflow through your windpipe and causes you to stop breathing temporarily. Signs and symptoms of sleep apnea include snoring loudly; gasping for air during sleep; waking up several times during the night; waking up with a headache, sore throat or dry mouth; and memory or learning problems.

Treatments for obstructive sleep apnea include losing weight or using a continuous positive airway pressure (CPAP) device that keeps your airway open while you sleep. CPAP treatment appears to lower the risk of heart disease from sleep apnea.

6. Get regular health screenings

High blood pressure and high cholesterol can damage your heart and blood vessels. But without testing for them, you probably won't know whether you have these conditions. Regular screening can tell you what your numbers are and whether you need to take action.

  • Blood pressure. Regular blood pressure screenings usually start in childhood. Adults should have their blood pressure checked at least every two years. You may need more-frequent checks if your numbers aren't ideal or if you have other risk factors for heart disease. Optimal blood pressure is less than 120/80 millimeters of mercury.
  • Cholesterol levels. Adults should have their cholesterol measured at least once every five years starting at age 20 if they have risk factors for heart disease, such as obesity or high blood pressure. If you're healthy, you can start having your cholesterol screened at age 35 for men and 45 for women. Some children may need their blood cholesterol tested if they have a strong family history of heart disease.
  • Diabetes screening. Since diabetes is a risk factor for developing heart disease, you may want to consider being screened for diabetes. Talk to your doctor about when you should have a fasting blood sugar test to check for diabetes. Depending on your risk factors, such as being overweight or having a family history of diabetes, your doctor may recommend early screening for diabetes. If your weight is normal and you don't have other risk factors for type 2 diabetes, the American Diabetes Association recommends starting screening at age 45, and then retesting every three years.

sábado, 18 de abril de 2015

Aveia com maçã e ameixa.

 

Gosta de aveia e de maçãs?  Em uma vasilha de alumínio com 1 litro de capacidade, coloque 200 ml de água filtrada,  mais 4 a 8 colheres das de sopa de aveia, dependendo de quanto você está acostumado a comer aveia, e do funcionamento do seu intestino. Faça um preparo-teste com porções menores de aveia.
(aveia contém Glúten) em seguida descasque uma maçã grande, lavando-a primeiro, não retire a casca pois esta é a parte mais importante da maçã, vá cortando em pequenos pedaços e colocando na vasilha onde está a aveia. Se a maçã for pequena poderá utilizar 2 delas.
Cozinhe em fogo brando até levantar fervura, deixe esfriar, se puder comer açúcar coloque apenas uma colher das de sopa.  A maçã assim cozida deverá ficar mole. Poderá também adicionar algumas ameixas sem caroços, apenas umas quatro. Coma de manhã ou ao anoitecer.

Se a quantidade de aveia for pequena, (2 colheres das de sopa) diminua proporcionalmente a quantidade de água. 125 ml para 2 colheres de aveia.. Eu que já estou acostumado, utilizo 400 ml de água e 8 colheres das de sopa de aveia.

sexta-feira, 17 de abril de 2015

Why China's rule changes are hitting US markets

 

27 Mins AgoCNBC.com

New rules for trading Chinese stocks spooked European and U.S. markets on Friday. (Tweet This)

Chinese exchanges and regulators announced Friday that they would crack down on over-the-counter margin trading and that they would allow fund managers to lend shares for short-selling.

The type of stocks that investors can short sell will also be expanded soon to 1,100, from 900 currently. All of these moves could slow Chinese equities' wild run higher in recent months.

Read MorePerfect storm for market correction: Expert

Investors observe stock market at a stock exchange corporation on April 17, 2015 in Jiujiang, Jiangxi province of China.

ChinaFotoPress | Getty Images

Investors observe stock market at a stock exchange corporation on April 17, 2015 in Jiujiang, Jiangxi province of China.

Although the Shanghai Stock Exchange Composite Index rose 2.2 percent in Friday trading, Chinese after-hours stock futures fell about 5.5 percent in a response to the new regulations.

Traders said U.S. and European markets were then in turn spooked by the move in those futures, and worries that the regulatory changes would be negative for the flow of recent money that has poured into Chinese exchanges.

"The securities regulator is encouraging short-selling to institutional investors, and they are going to stop margin trading on OTC," Ioan Smith, managing director of KCG Europe, said. "Traders had to catch up with that news after the Bloomberg terminals came back online, and that's when we saw the falls in Europe." (Terminals were briefly down earlier Friday)

Read MoreSee how US markets are trading here

News of the Chinese changes followed comments from the China Securities Regulatory Commission indicating the agency expected future good fortunes for equities. Xiao Gang, who leads the CSRC, said investors should not think they are missing the boat if they had not yet invested in the Chinese stock market, which has surged around 70 percent since November.

"So apparently they told us that the bull market in Chinese stocks was going to last, and then they pulled the rug? I is confused," Rhino Trading Partners' Michael Block (actually) wrote in a Friday note.

He attributed a 14 point decline in S&P futures and a 4 percent decline in the iShares China Large-Cap exchange traded fund to this news. European shares also traded down in part because of the China news, Block added.

"I didn't realize China would have such an effect on the U.S. and Europe," he wrote. "The [Shanghai Stock Exchange Composite Index] is up over 32% this year. The [S&P 500] is barely up over 2%. But c'est la vie, apparently."

Although there has not been a perfect correlation between U.S. stocks and booming Chinese equities, any worries about the future of those markets would cause some doubts stateside, according to Jim Meyer, CEO of Tower Bridge Advisors.

"The Chinese market has been a source of strength," he explained, so any decline could rattle equities traders.

Read MoreForget China, this market is Asia's sweet spot

Any global weakness from the Chinese regulatory changes should be temporary, however, said Adrian Day of Adrian Day Asset Management.

Such a move was not unexpected, he said, given the fact that Chinese equities "have sort of gone crazy" with massive gains in recent months. And while the new rules may tamp down on those prices, the easily-spooked global markets should move along to the next focal point.

"By next week the rest of the world will have forgotten about it," Day said.

—Reuters and CNBC's Evelyn Cheng contributed to this report.

Patents forecast technological change

 

Thu, 04/16/2015 - 12:20pm

MIT News Office

How fast is online learning evolving? Are wind turbines a promising investment? And how long before a cheap hoverboard makes it to market?

Attempting to answer such questions requires knowing something about the rate at which a technology is improving. Now engineers at Massachusetts Institute of Technology (MIT) have devised a formula for estimating how fast a technology is advancing, based on information gleaned from relevant patents.

The researchers determined the improvement rates of 28 different technologies, including solar photovoltaics, 3-D printing, fuel-cell technology and genome sequencing. They searched through the U.S. Patent Office database for patents associated with each domain—more than 500,000 total—by developing a novel method to quickly and accurately select the patents that best represent each technology.

Once these were identified, the researchers analyzed certain metrics across patents in each domain, and found that some were more likely to predict a technology’s improvement rate than others. In particular, forward citations—the number of times a patent is cited by subsequent patents—is a good predictor, as is the date of a patent’s publication: Technologies with more recent patents are likely innovating at a faster rate than those with older patents.

The team devised an equation incorporating a patent set’s average forward citation and average publication date, and calculated the rate of improvement for each technology domain. Their results matched closely with the rates determined through the more labor-intensive approach of finding numerous historical performance data points for each technology.

Among the 28 domains analyzed, the researchers found the fastest-developing technologies include optical and wireless communications, 3-D printing and MRI technology, while domains such as batteries, wind turbines and combustion engines appear to be improving at slower rates.

Chris Benson, a former graduate student in MIT’s Dept. of Mechanical Engineering, says the new prediction tool may be of interest to venture capitalists, startups and government and industry labs looking to explore new technology.

“There’s a lot of nuance to our method, and I don’t see it as something to hand out to the masses to play with,” says Benson, who helped developed the prediction tool. “I see it more as something where we work with somebody to help them understand what the future technological capabilities that they’re interested in are. We’re probably more like a real estate agent, and less like Zillow.”

Benson and Chris Magee, a professor of the practice of engineering systems at MIT, have published their results in PLoS ONE. The paper contains the fundamental findings and equations relating technological improvement to a variety of patent characteristics.

Technological dynamism
In 2003, Magee began determining the improvement rates of various technologies. At the time, he was curious how technologies were developing relative to Moore’s Law—an observation pertaining originally to computers, in which transistors on a computer chip double every two years.

“There were a lot of things that weren’t going as fast as Moore’s Law, and I started trying to get measures of them,” Magee recalls.

Magee initially approached the problem on a case-by-case basis, determining which metrics best represent productivity for a given domain. He then compiled data for each metric, such as the price and speed of manufacturing a product, and used the data to calculate the overall rate of improvement. In 2010, he realized that one of the most comprehensive resources on technology lay in the U.S. patent record.

“We thought, ‘Maybe there’s enough information there that we can do something about linking it to the dynamism of technical change,’” Magee says.

For several years, he and his group identified the most relevant patents in a technological domain, by literally reading through thousands of patents—an incredibly time-intensive process. The approach was not very reliable, as two people may choose entirely different sets of patents to represent the same technology.

A “Standard & Poor’s” for technology
In 2012, Magee and Benson came up with a more efficient, repeatable method for identifying relevant patent sets, by looking at the overlap between the U.S. and international patent-classification systems.

For each patent accepted by the U.S. Patent Office, a patent reviewer will file the patent under several classes within both classification systems. For instance, a solar photovoltaics patent may be entered under the U.S. classes “batteries” and “active solid-state devices” and within the international system as “semiconductor devices.”

The team found that by looking for patent overlap between both classification systems, they could repeatedly identify the same set of patents that best represent a technology, within a matter of hours, rather than months.

Once they identified a relevant set of patents, the researchers looked for metrics within patents that they could use to calculate a technology’s rate of improvement. They found that a patent set’s average forward citations within the first three years after publication, and the average date of publication, were the best predictors of technological improvement. Benson says they were also able to weed out less-helpful patent information.

“If a technology has more patents in general, it should be moving faster, but that turns out not to be the case,” Benson says. “3-D printing only has 300 to 500 patents, and that’s improving at the same rate as semiconductors, which have about 150,000 patents. So there’s almost zero correlation.”

The team devised a simple equation incorporating forward citation and publication date, and used the method to predict improvement rates for 28 technologies. The researchers then compared the rates with those they previously obtained using their more time-intensive, historical data-based approach, and found the results from both methods matched closely.

They then used their more efficient approach to predict the improvement rates of 11 emerging technologies in the next 10 years. Among these, the fastest-growing domains appear to be online learning and digital representation, while slower technologies include food engineering and nuclear fusion.

Doyne Farmer, a professor of mathematics at Oxford Univ., says that the notion that technological progress is predictable “is both intellectually fascinating and quite powerful in its practical implications.”

“[The group’s] methods should be useful to any organization that is considering investments in technology, in particular government funding agencies such as the [U.S. Department of Energy] that fund engineering applications; venture-capital firms; or firms that are actually in the technology business,” says Farmer, who was not involved in the research. “Making the right bets on technological progress is essential for solving problems such as climate change. Thus, we should all benefit from this work.”

Magee hopes the method may be used much like a rating system, similar to Standard & Poor’s and other stock-market indices. Such ratings could be useful for investors looking for the next big breakthrough, as well as scientific labs that are contemplating new research directions. Magee says knowing how various technologies may improve in the next decade could give innovators an idea of when “feeder technologies” may mature, and enable more pie-in-the-sky ideas, like mass-produced hoverboards and flying cars.

“We can help reduce the uncertainty of the capabilities of a technology in the future, not to zero, but to a more manageable number,” Benson says. “I believe that’s valuable in a lot of different ways.”

Source: Massachusetts Institute of Technology

Scientists discover protein that boosts immunity to viruses and cancer

April 16, 2015

Imperial College London

Scientists have discovered a protein that plays a central role in promoting immunity to viruses and cancer, opening the door to new therapies. Experiments in mice and human cells have shown that the protein promotes the proliferation of cytotoxic T cells, which kill cancer cells and cells infected with viruses. The discovery was unexpected because the new protein had no known function and doesn’t resemble any other protein.


Scientists have discovered a protein that plays a central role in promoting immunity to viruses and cancer, opening the door to new therapies.

Experiments in mice and human cells have shown that the protein promotes the proliferation of cytotoxic T cells, which kill cancer cells and cells infected with viruses. The discovery was unexpected because the new protein had no known function and doesn’t resemble any other protein.

Researchers from Imperial College London who led the study are now developing a gene therapy designed to boost the infection-fighting cells, and hope to begin human trials in three years. 

The study also involved researchers at Queen Mary University of London, ETH Zurich and Harvard Medical School. Their discovery, which has been six years in the making, is reported today in the journal Science.

Cytotoxic T cells are an important component of the immune system, but when faced with serious infections or advanced cancer, they are often unable to proliferate in large enough quantities to fight the disease.

By screening mice with genetic mutations, the Imperial team discovered a strain of mice that produced 10 times as many cytotoxic T cells when infected with a virus compared with normal mice. These mice suppressed the infection more effectively, and were more resistant to cancer. They also produced more of a second type of T cells, memory cells, enabling them to recognise infections they have encountered previously and launch a rapid response.

The mice with enhanced immunity produced high levels of a hitherto unknown protein, which the researchers named lymphocyte expansion molecule, or LEM. They went on to show that LEM modulates the proliferation of human T cells as well as in mice.

The researchers now aim to develop a gene therapy designed to improve immunity by boosting the production of LEM. With the support of Imperial Innovations, the technology commercialisation company for the College, the researchers have filed two patents. A company called ImmunarT has been formed with the aim of commercialising the technology.

Professor Philip Ashton-Rickardt from the Section of Immunobiology in the Department of Medicine at Imperial, who led the study, said: “Cancer cells have ways to suppress T cell activity, helping them to escape the immune system. Genetically engineering T cells to augment their ability to fight cancer has been a goal for some time and techniques for modifying them already exist. By introducing an active version of the LEM gene into the T cells of cancer patients, we hope we can provide a robust treatment for patients. 

“Next we will test the therapy in mice, make sure it is safe and see if it can be combined with other therapies. If all goes well, we hope to be ready to carry out human trials in about three years.”

Dr Claudio Mauro, who led the research from the Centre for Biochemical Pharmacology, based within Queen Mary University of London’s William Harvey Research Institute, said: “This study has identified the novel protein LEM and unlocked an unexpected way of enhancing the ability of our immune system to fight viruses or cancers. This is based on the ability of the protein LEM to regulate specific energy circuits, and particularly mitochondrial respiration, in a subset of white blood cells known as cytotoxic T cells. This discovery has immediate consequences for the delivery of innovative therapeutic approaches to cancer. Its ramifications, however, are far greater as they can help explaining the biological mechanisms of widespread human diseases involving altered immune and inflammatory responses. These include chronic inflammatory and autoimmune disorders, such as atherosclerosis and rheumatoid arthritis.”

The research was funded by the Medical Research Council, the Wellcome Trust and the British Heart Foundation.

Dr Mike Turner, Head of Infection and Immunobiology at The Wellcome Trust, said: “The discovery of a protein that could boost the immune response to not only cancer, but also to viruses, is a fascinating one. Further investigation in animal models is needed before human trials can commence, but there is potential for a new type of treatment that capitalises on the immune system’s innate ability to detect and kill abnormal cells.”

Facebook users' wishful thinking: Cyberbullying, depression won't happen to me

April 16, 2015

Dartmouth College

Facebook users with so-called optimistic bias think they're less likely than other users to experience cyberbullying, depression and other negative social and psychological effects from using the site, a study finds. The study suggests that optimistic bias, or an intrinsic tendency to imagine future events in a favorable light that enhances positive self-regard -- in other words, wishful thinking -- leaves those Facebook users vulnerable to the negative realities of social media.


Facebook users with so-called optimistic bias think they're less likely than other users to experience cyberbullying, depression and other negative social and psychological effects from using the site, a Dartmouth-Cornell study finds.

The study suggests that optimistic bias, or an intrinsic tendency to imagine future events in a favorable light that enhances positive self-regard -- in other words, wishful thinking -- leaves those Facebook users vulnerable to the negative realities of social media.

The findings appear in the journal Cyberpsychology, Behavior, and Social Networking.

"Our findings demonstrate important and novel discrepancies in how people perceive themselves and others concerning the positive and negative outcomes of Facebook use," says lead author Sunny Jung Kim, a postdoctoral research associate in the Psychiatric Research Center and the Center for Technology and Behavioral Health at the Geisel School of Medicine at Dartmouth. "A growing number of studies report possible benefits and risks of using Facebook and other social media, ranging from effects on self-esteem to cyberbullying. But little is known about how people perceive themselves to be likely to experience these mixed outcomes and what the implications of having these perceptions are."

In the new study, the researchers surveyed 237 active Facebook users between ages 18 and 37. The participants were asked to assess their own and other people's likelihood of experiencing positive and negative outcomes on Facebook. They also were asked to rate their likelihood of supporting Internet regulations, their personal Facebook involvement and their attitudes toward Facebook use. The results show that Facebook users with optimistic bias tend to show strong support for Internet regulations to protect other users from social ostracizing, although not from psychologically negative effects, including depression and loneliness. The lack of support regarding psychological harms may be because mental health effects are perceived as less amenable to regulation or because their importance is underestimated, the researchers say.

The results also show that Facebook users who view the site negatively or who use it infrequently think other people are more likely than themselves to have positive experiences on the site, a reversed optimistic bias that is new and intriguing. "When ostensibly positive outcomes, such as receiving social support from Facebook friends, are perceived to be unusual and irrelevant for themselves, the direction of the optimistic bias for these objectively positive outcomes can be dampened or even reversed," Kim says. Co-author Cornell Professor Jeffrey Hancock adds: "It's fascinating that well-established, third-person effects are also seen on Facebook, but the reversal shows how social media is not identical to mass media."

"Although some might argue that it is still premature to claim that Facebook use is a direct predictor of extreme events such as clinical depression and suicidal attempts, a growing line of research indicates that negative events such as Facebook cyberbullying can result in detrimental consequences, including depression and substance use problems," Kim says. "Without adequate protections, the damage of these critical events can be severe. This is especially the case for those in a vulnerable health condition, in which this optimistic bias for risk events can leave them unprepared without adequate health protective behaviors. We argue that Facebook may serve as a source of emotional support between users and as a platform to disseminate protective health messages to prevent negative psychological consequences of Facebook use. Given that negative personal and health news such as stressful events and depressive symptoms are frequently shared on Facebook, it may be an important site for observing negative psychological states of users."


Story Source:

The above story is based on materials provided by Dartmouth College. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sunny Jung Kim, Jeffrey T. Hancock. Optimistic Bias and Facebook Use: Self–Other Discrepancies About Potential Risks and Benefits of Facebook Use. Cyberpsychology, Behavior, and Social Networking, 2015; 18 (4): 214 DOI: 10.1089/cyber.2014.0656