domingo, 12 de outubro de 2014

Computerized surveillance system quickly detects disease outbreaks among preschoolers

 


A web-based system that allows preschools and child care centers to report illnesses to local public health departments could improve the detection of disease outbreaks and allow resources to be mobilized more quickly, according to University of Michigan research to be presented Saturday, Oct. 11 at the American Academy of Pediatrics (AAP) National Conference & Exhibition in San Diego.

Researchers who designed the biosurveillance system will describe how it can be used to track illness trends and improve public health response to outbreaks during a presentation at 2:09 p.m. PDT in Marina Ballroom Salon E at the San Diego Marriott Marquis.

"For example, if certain child care centers are reporting the beginning of stomach flu (vomiting and diarrhea), other centers can start taking steps to thoroughly clean to kill any viruses before symptoms occur or before a major outbreak takes place," says Andrew N. Hashikawa, M.D., F.A.A.P., a pediatric emergency physician at the University of Michigan's C.S. Mott Children's Hospital.

In addition, if child care providers see that larger centers in their community are reporting flu-like illness, they can use the data to emphasize to parents the need to have their children immunized against influenza sooner rather than later, says Hashikawa, who also is assistant professor in the Department of Emergency Medicine, Division of Pediatric Emergency Medicine, at the University of Michigan Medical School.

Children under age 5 generally become sick earlier and more frequently than school-aged children and adults because their immune systems are underdeveloped. Young children often are responsible for spreading viruses to the rest of the community.

Previously some public health departments have found that school absenteeism as a marker for illness was imprecise, delayed, and unavailable during summer and winter breaks.

"However, child care or preschool absences are typically more likely to be associated with illness and most young children continue to need child care for most of the year," says Hashikawa, a member of the U-M Institute for Healthcare Policy and Innovation.

Most public health departments do not electronically track influenza or stomach illnesses in preschools and child care centers settings.

"Most illness reporting methods used by many public health departments are slow, paper-based and inefficient," says Hashikawa.

To improve reporting, Hashikawa and his colleagues created a computerized system and tested it at four early learning centers in Michigan. Staff were trained to use the system daily to report any ill child. No confidential or identifying information was collected. They entered data on illness type and symptoms in seven categories commonly seen in preschoolers: fever, influenza-like illness, pink eye, stomach illnesses (gastroenteritis), cold or respiratory symptoms, ear infections and rash. They also entered the age range of the ill child (infant, 0-12 months), (toddler, 13-35 months) or (preschooler, 36-59 months), daily attendance at their center, and action taken (e.g., child brought to a physician).

Researchers sent data electronically to the public health department weekly or more frequently if spikes in illness cases were seen.

Results showed centers reported 188 individual episodes of illness from Dec. 10, 2013, through March 28, 2014. Nearly 15 percent were infants, 32 percent were toddlers and 54 percent were preschoolers. The most common illnesses reported were gastroenteritis (37 percent), fever (31 percent), cold (17 percent) and influenza (3 percent).

Data also revealed an unusually large increase in gastroenteritis cases during a two-day period, which was comparable to a countywide spike among schools reported three weeks later.

"Preliminary data suggest that using the online biosurveillance in child care centers and preschools gives us an earlier detection and warning system because the younger children appeared to become sick first compared to middle school and high school aged children within the community," says Hashikawa.


Story Source:

The above story is based on materials provided by University of Michigan Health System. Note: Materials may be edited for content and length.


 

Hidden population: Thousands of youths take on caregiver role at home

 


While the typical preteen or adolescent can be found playing sports or video games after school, more than 1.3 million spend their free time caring for a family member who suffers from a physical or mental illness, or substance misuse.

These "caregiving youth" are a hidden population who are at risk of school failure and poor health due to the chronic physical and emotional stress of their responsibilities at home, said Julia Belkowitz, MD, FAAP, author of an abstract titled "Caregiving Youth Project: A School-Based Intervention to Support a Hidden Population in Need." The study will be presented Oct. 11 at the American Academy of Pediatrics (AAP) National Conference & Exhibition in San Diego.

Dr. Belkowitz, assistant professor of pediatrics at the University of Miami Miller School of Medicine, and her colleagues worked with the American Association of Caregiving Youth (AACY) to better understand the experiences of caregiving youth in Palm Beach County, Fla. They also studied the impact of services provided by AACY to caregiving youth, including a support system, skills-building classes, home health and community resources, tutoring and respite services along with sponsored fun activities.

"AACY services in Palm Beach County reach only the tip of the iceberg," said Connie Siskowski, RN, PhD, founder and president of AACY. "Today in the U.S., there are many more than the 1.3 million children identified in 2005 who face the challenges of juggling adult-sized responsibilities of caring for ill, injured, aging or disabled family members while trying to keep up at school."

Researchers analyzed approximately 550 intake forms completed by the AACY with youth caregivers. The forms included information on demographics, caregiving activities and health status collected at eight middle schools in Palm Beach County, FL. They also reviewed 200 family intake forms completed when a social worker conducted a home visit with the families, as well as feedback forms completed annually by youth participating in AACY activities.

Sixty-two percent of the youth caregivers were girls; 38% were boys. The median age of caregivers was 12 years.

Youth caregivers reported spending a median of 2.5 hours each school day and four hours each weekend day performing caregiving tasks at home. Estimates of median caregiving task time reported by family members were slightly lower at 1.5 hours on weekdays and 2.25 hours on weekend days.

These tasks include assisting family members with getting around, eating, dressing, toileting, bathing and continence care. Youth caregivers also kept the family member company, provided emotional support, cleaned the house, shopped for groceries, administered medications, translated in clinical settings and handled medical equipment at home.

"This study is an important step toward raising awareness about the issue of caregiving youth," said Dr. Belkowitz, who also is assistant regional dean for student affairs at the regional campus of the Miller School. "The AACY is developing partnerships throughout the nation to further understand this special population and expand programming to provide the resources and support these young people need and deserve."


Story Source:

The above story is based on materials provided by American Academy of Pediatrics. Note: Materials may be edited for content and length.


 

Incorrect use of car seats widespread on first trip home from hospital, research shows

 


Nearly all parents unknowingly put their newborn infants at risk as soon as they drive away from the hospital due to mistakes made with car safety seats, according to research to be presented Oct. 13 at the American Academy of Pediatrics (AAP) National Conference & Exhibition in San Diego.

A study of 267 families at Oregon Health and Science University Hospital showed that 93 percent made at least one critical error in positioning their infant in a car safety seat or when installing the safety seat in the vehicle. The National Highway Traffic Safety Administration has defined critical errors as those that put infants at increased risk for injury in a crash.

"Car safety seats can be difficult to use correctly for many families, and we need to provide the resources and services they need to help ensure the safest possible travel for newborns and all children," said Benjamin Hoffman, MD, FAAP, lead author of the study "Unsafe from the Start: Critical Misuse of Car Safety Seats for Newborns at Initial Hospital Discharge."

Dr. Hoffman and his colleagues enrolled randomly selected mother-infant pairs in the hospital's mother-baby unit from November 2013 to May 2014. Infants born at less than 37 weeks' gestation and those who stayed in the neonatal intensive care unit for more than four hours were excluded from the study.

A certified child passenger safety technician observed new mothers or a designee position the newborn in the car safety seat and install the seat in the vehicle in which they would be leaving the hospital. The technician recorded all misuses based on car safety seat and vehicle manufacturer recommendations. Prior to departure, technicians helped caregivers correct all mistakes.

The most common errors in positioning the infant included harness being too loose (69 percent), retainer clip too low (34 percent), use of after-market product not approved with seat (20 percent), harness too high (18 percent) and caregiver not knowing how to adjust the harness (15 percent).

The most common installation errors were car safety seat installed too loosely (43 percent), angle of car safety seat incorrect (36 percent), safety belt used but not locked (23 percent) and incorrect spacing between car safety seat and vehicle front seat (17 percent).

Families with increased risk for one or more critical errors tended to be of lower socioeconomic status, had less education, were non-white, did not speak English, and were unmarried or without a partner. Families who had worked with a certified car seat technician prior to their child's birth were 13 times more likely to position their baby correctly and install the car seat correctly in their vehicle.

"We need to move beyond the idea that we cannot afford to develop and support child passenger safety programs," said Dr. Hoffman, professor of pediatrics and medical director of the Tom Sargent Children's Safety Center at Doernbecher Children's Hospital, Portland, Ore. "Car crashes kill more kids that any other cause; we can't afford not to."


Story Source:

The above story is based on materials provided by American Academy of Pediatrics. Note: Materials may be edited for content and length.


 

sábado, 11 de outubro de 2014

Pneumococcal vaccine reduces antibiotic-resistant infections in children by 62 percent

 

October 10, 2014

Infectious Diseases Society of America

The pneumococcal vaccine recommended for young children not only prevents illness and death, but also has dramatically reduced severe antibiotic-resistant infections, suggests American nationwide research. Pneumococcal infection -- which can cause everything from ear infections to pneumonia and meningitis -- is the most common vaccine-preventable bacterial cause of death.


The pneumococcal vaccine recommended for young children not only prevents illness and death, but also has dramatically reduced severe antibiotic-resistant infections, suggests nationwide research being presented at IDWeek 2014™. Pneumococcal infection -- which can cause everything from ear infections to pneumonia and meningitis -- is the most common vaccine-preventable bacterial cause of death.

The 13-valent pneumococcal conjugate vaccine (PCV13), first available in 2010 (replacing 7-valent pneumococcal conjugate vaccine, PCV7), reduced the incidence of antibiotic-resistant invasive pneumococcal disease by 62 percent from 2009 to 2013 among children under five years old. The study is the first report of the effectiveness of PCV13 to combat antibiotic-resistant infections, a vaccination recommended for children under five years old. Three-quarters of states require it for entry into daycare, and 85 percent of U.S. children have received the recommended four doses.

"We're at risk of living in a post-antibiotic world, where these miracle medications no longer work, but this vaccine is part of the solution to protecting ourselves from the growing threat of antibiotic resistance," said lead researcher Sara Tomczyk, PHN, MSc, epidemic intelligence service (EIS) officer for the Respiratory Diseases Branch, Centers for Disease Control and Prevention (CDC), Atlanta. "Not only does this vaccine prevent pneumococcal infection, which means fewer antibiotics are prescribed, but it also prevents antibiotic-resistant infections."

The U.S. government's Healthy People 2020 initiative set a goal of reduction of antimicrobial-resistant invasive pneumococcal disease from 9.3 to 6 cases per 100,000 children. In the course of analyzing the data for this study, the team realized the goal had been met nine years early due to the effectiveness of the pneumococcal vaccine. Currently, the rate is 3.5 cases per 100,000 children.

PCV13 is given to children in four doses, at two, four, six and 12 through 15 months of age. The study collected data representing approximately 10 percent of the United States, which is considered illustrative of the country as a whole, said Tomczyk. PCV13 is effective against 13 strains of pneumococcal bacteria, while PCV7 was effective against seven. One dose of PCV13 also is now recommended for all adults 65 and older, followed by a dose of the pneumococcal polysaccharide vaccine (PPSV23) six to 12 months later. Additionally, one dose of PCV13 is recommended for adults 19 and older with certain cancers, HIV and kidney failure, followed by doses of PPSV23.


Story Source:

The above story is based on materials provided by Infectious Diseases Society of America. Note: Materials may be edited for content and length.


 

Moms who choose to breastfeed older babies motivated by health, nutrition benefits

 


Mothers who decide to breastfeed their children beyond 1 year of age consider their child's physical and social development to be most important, while the advice of health care professionals, family and friends are least important, according to a study to be presented Monday, Oct. 13 at the American Academy of Pediatrics (AAP) National Conference & Exhibition in San Diego.

To find out why some moms choose to continue nursing after a child's first birthday, researchers surveyed more than 50,000 U.S. women ages 18-50.

"The three most important reasons that mothers gave for extended nursing were the nutritional benefits of breast milk, the other health benefits of breast milk and the opportunity to build a stronger social bond with their baby," said principal investigator Alexis Tchaconas, research assistant, developmental and behavioral pediatrics at the Steven and Alexandra Cohen Children's Medical Center of New York.

The investigators designed an online survey that asked mothers to rank 15 factors related to extended breastfeeding as "very important," "important," "somewhat important" or "not important." Surveys were sent to mothers via email lists from La Leche League, an international breastfeeding support organization, as well as Facebook groups and online chat rooms dedicated to breastfeeding support.

Besides health benefits and bonding with their child, other top factors that influenced mothers to breastfeed beyond one year included enjoyment, support from spouse or partner, La Leche League support and not having to pay for formula.

"Although most women felt comfortable discussing their decision to nurse their baby beyond 1 year of age with their child's pediatrician and with their own health care providers, the recommendations of these health care professionals were not identified as being important in terms of the mother's decision to extend nursing," said senior investigator Andrew Adesman, MD, FAAP, chief of developmental and behavioral pediatrics at the Steven and Alexandra Cohen Children's Medical Center of New York.


Story Source:

The above story is based on materials provided by American Academy of Pediatrics. Note: Materials may be edited for content and length.


 

Brasil permaneceu na 17ª colocação no quesito desigualdade no G-20

 

Agência Estado

Publicação: 10/10/2014 17:25 Atualização:

O Brasil se manteve em 2013 entre os países mais desiguais do G-20 pelo terceiro ano consecutivo, mostrou estudo elaborado pela Associação Nacional dos Executivos de Finanças, Administração e Contabilidade (Anefac) com base em uma compilação de números da Organização das Nações Unidas (ONU).
O Brasil continuou na 17ª colocação no quesito desigualdade social, à frente apenas de África do Sul e Índia. Em quatro anos de pesquisa, o melhor desempenho brasileiro foi em 2010, quando ocupava a 15ª posição. O levantamento desconsidera a participação da União Europeia e, por isso, conta com 19 países.
"Particularmente o coeficiente de Gini é um indicador importante relacionado a este ranking e mostra o Brasil em situação bastante desconfortável com relação à distribuição da renda (...). O Brasil tem melhorado neste coeficiente de Gini ao longo dos últimos anos, no entanto, ainda há um longo caminho a percorrer", alertou a Anefac. Austrália, Alemanha e Canadá aparecem como os países menos desiguais do G-20, nesta ordem.
O Brasil ocupou a 14ª colocação no ranking de pobreza, mesmo patamar do ano anterior. "Os países abaixo do Brasil nesse ranking apresentam desempenho que não ameaça a 14ª posição brasileira, porém, aliado ao indicador de desigualdade, constata-se uma distância entre a posição do Brasil como economia global em relação à posição correspondente ao desenvolvimento humano", explicou a Anefac. Abaixo do Brasil seguem México, Indonésia, África do Sul, China e Índia. A associação acrescentou que aproximadamente 10% da população brasileira vive na miséria, e 10 milhões vivem com apenas US$ 1 25 por dia.
No ranking geral, que além desses itens já citados leva em conta tópicos como IDH, Saúde, Educação, Renda e Economia, Desigualdade de Gênero e Sustentabilidade, o Brasil manteve a 15ª colocação pelo segundo ano consecutivo, à frente de Turquia, Indonésia, África do Sul e Índia. A associação explicou que a nota brasileira melhorou, subindo de 4,22 pontos para 4,45 pontos, mas ponderou que os demais países progrediram mais.
As primeiras posições do ranking geral são ocupadas por Alemanha França e Canadá. Os EUA, maior economia do mundo, estão na oitava colocação. Segundo a Anefac, esse desempenho norte-americano é explicado pelas pontuações fracas nas categorias Saúde e Educação.
O Brasil piorou nas avaliações de IDH (14 para 15), Educação (14 para 15) e Desigualdade de Gênero (14 para 17). O País apresentou estabilidade em Saúde (13) e melhorou em Sustentabilidade (3 para 2) e em Renda e Economia (15 para 11). Este último item passou por uma revisão de critério em relação ao ano anterior. Segundo a Anefac, o Brasil "não apresenta um posicionamento equivalente nos indicadores que compõem a avaliação de renda na ONU".

Snap 2014-10-11 at 14.15.27

HTC goes into the actioncam market, with the RE

 

HTC's pipe-like RE actioncam

HTC's pipe-like RE actioncam

Image Gallery (5 images)

Although HTC is best-known for its smartphones, today the company announced its venture into another product category – actioncams. The company has announced the RE, a viewfinder-less waterproof video camera that looks sort of like something you'd find in a plumbing store.

The RE has a 16-megapixel CMOS sensor, an f2.8 146-degree lens, and records 1080p/30fps video. A sensor in its hand grip automatically turns the camera on when it's picked up – there's no power switch. From there, a quick tap of its single shutter button snaps stills, with a longer press required for video.

Using the upcoming Android/iOS RE app, users can access recording features such as time-lapse, plus the app screen serves as a remote viewfinder for setting up and reviewing shots.

Footage/photos can be streamed to a paired smartphone (and onward to the cloud) via Blueto...

Footage/photos can be streamed to a paired smartphone (and onward to the cloud) via Bluetooth, and recorded on a user-supplied microSD card. One charge of the RE's 820-mAh battery should reportedly be good for approximately 1,200 photos or 1 hour and 40 minutes of continuous video recording.

As mentioned, it's also waterproof – it's rated to IPX7, meaning that it can be immersed for 30 minutes at a depth of 1 meter (3.3 ft).

 

Source: HTC

 

Intracranial stents: More strokes than with drug treatment alone

 


The risk of having another stroke is higher if patients, after dilation of their blood vessels in the brain, not only receive clot-inhibiting drugs, but also have small tubes called stents inserted. However, studies have provided no hint of a benefit from stenting, which is also referred to with the abbreviation "PTAS." This is the conclusion reached in the rapid report of the German Institute for Quality and Efficiency in Health Care (IQWiG), as published on 9 October 2014.

Stents are supposed to prevent restenosis

Blood vessels in the brain that are narrowed or blocked can cause stroke. If patients have already had a stroke or temporary ischaemia (transient ischaemic attack, TIA), there is a high risk that this occurs again. These patients therefore receive drugs that prevent blood clotting. Another option is to additionally widen the narrowed vessels.

Nowadays this is often done using a small balloon in a procedure known as percutaneous transluminal angioplasty (PTA). But even after PTA and simultaneous blood-thinning medication, vessels often remain narrow (stenosis) or new narrowing occurs (restenosis). The treatment has therefore been expanded to include stenting (percutaneous transluminal angioplasty and stenting, PTAS): Small wire mesh tubes are inserted to support the widened blood vessels and prevent restenosis. This stenting has been available for approximately 10 years.

Compare PTAS with treatment alternatives

The Federal Joint Committee (G-BA) had commissioned IQWiG to assess the benefit of PTAS for patients with symptoms of narrowed blood vessels in the brain (symptomatic intracranial stenosis). PTAS was to be compared with drug treatment with blood-thinning medications alone and with balloon dilatation without stenting (PTA). Like PTAS, PTA always involves administration of blood-thinning drugs.

Four studies identified

IQWiG identified a total of four randomized controlled trials (RCTs) that included patients with symptomatic intracranial stenosis. In three studies, PTAS was compared with drug treatment alone. One study tested PTAS versus PTA.

One relevant study on PTAS versus medication alone

The SAMMPRIS study was relevant for the assessment of PTAS in comparison with drug treatment alone. SAMMPRIS included a total of 451 participants and is the largest study currently available. It is also the only study to provide data both on mortality and side effects and on stroke in all areas of the brain.

The two other studies (Miao 2012 and Gao 2013) only reported strokes that occurred in the territory of the treated vessels. However, it is relevant for the patients whether strokes occur at all -- irrespective of their localization. Hence only data from the SAMMPRIS study were available for the outcome "stroke" as well.

Lack of data for important outcomes

Besides mortality (all-cause mortality and from stroke), the burden of disease in the form of stroke, TIA, and other physical or psychological impairments from ischaemia, the patient-relevant outcomes of this assessment also include side effects (e.g. bleeding events or myocardial infarction) and dependence on others or requiring care. However, these were not fully reported in any of the studies. None of the four studies provided results on further criteria that are important for patients such as health-related quality of life, hospitalization or physical endurance.

Considerably more strokes in temporal proximity to the intervention

As the SAMMPRIS data showed, a new stroke is considerably more common in patients who have received an intracranial stent than in patients who only received medication: This was the case in 59 participants (26.3%) in the PTAS group, and in only 42 participants (18.5%) in the comparator group.

Differentiated by type of stroke, these differences can be determined in haemorrhagic stroke, i.e. stroke caused by bleeding, but not in ischaemic stroke, which is caused by narrowing. The haemorrhagic strokes were often periprocedural events occurring within 30 days of the intervention. In many cases, these strokes were apparently caused by mechanical manipulation during the placement of the stent.

No differences in morbidity and revascularization

These disadvantages are not accompanied by advantages in other outcomes: There was no relevant difference between the treatment groups in mortality (all-cause mortality and cerebrovascular mortality). The IQWiG report came to the same conclusion with regard to repeated revascularization, i.e. the necessity to widen narrowed vessels again.

Results potentially biased

All the studies included by IQWiG were subject to uncertainty and their results might be biased. The main reasons were unclear issues regarding randomization and the premature unplanned termination of the studies.

This is also true for SAMMPRIS, which started in November 2008, but was ended prematurely in April 2011 because considerably more events (counting deaths and strokes) had occurred in the PTAS group. Even though this decision is comprehensible, the results can be biased because of the premature termination of the study.

Despite the uncertainty described, IQWiG overall considers there to be a hint of harm from PTAS in comparison with drug treatment alone.

Drugs were not used in compliance with their approval

The interpretation of the SAMMPRIS results was made more difficult because the drugs were not used according to the specifications in the Summary of Product Characteristics valid in Germany: The patients in both groups received a combination of two clot-inhibiting drugs, acetylsalicylic acid (ASA) and clopidogrel (dual antiplatelet therapy). This combination is used in Germany, but is not approved for stroke because it is known to increase the risk of bleeding. It can also not be excluded that there is an interaction between the drugs and stent placement (PTAS), which particularly might influence the occurrence of bleeding.

RCTs indispensable in medical devices as well

PTAS is another example that high-quality studies are needed for risk class III medical devices, which also include stents: In the United States, intracranial stents had at first been approved for treatment of a specific, relatively small group of fewer than 4000 patients affected. This approval was based on case series and on the Humanitarian Device Exemption. However, Medicare, an American health insurance for elderly and disabled people, then demanded an RCT as prerequisite for its reimbursement of stents.

So the SAMMPRIS study, funded by the National Institutes of Health, was initiated. Only this RCT, i.e. a study with a higher level of evidence, revealed that more strokes occurred under the new, allegedly innovative Treatment.

Product safety is not the same as patient safety

This confirmed the conclusion already drawn in the case of antibody-coated stents inserted in coronary vessels: Not only the medical device is decisive, but also its manner of application. "The entire application including its accompanying factors has to be investigated, and not only the stents themselves, to obtain reliable knowledge about the benefit stents have for patients," concludes Stefan Sauerland, Head of the IQWiG Department of Non-Drug Interventions.

Executive Summary of the Rapid Report is available at: https://www.iqwig.de/download/N14-01_Executive-summary_Intracranial-stents.pdf


Story Source:

The above story is based on materials provided by Institute for Quality and Efficiency in Health Care. Note: Materials may be edited for content and length.


 

Milky Way has half the amount of dark matter as previously thought

 


This is an artist's impression of the Milky Way and its dark matter halo (shown in blue, but in reality invisible).

A new measurement of dark matter in the Milky Way has revealed there is half as much of the mysterious substance as previously thought.

Australian astronomers used a method developed almost 100 years ago to discover that the weight of dark matter in our own galaxy is 800,000,000,000 (or 8 x 1011) times the mass of the Sun.

They probed the edge of the Milky Way, looking closely, for the first time, at the fringes of the galaxy about 5 million billion kilometres from Earth.

Astrophysicist Dr Prajwal Kafle, from The University of Western Australia node of the International Centre for Radio Astronomy Research, said we have known for a while that most of the Universe is hidden.

"Stars, dust, you and me, all the things that we see, only make up about 4 per cent of the entire Universe," he said.

"About 25 per cent is dark matter and the rest is dark energy."

Dr Kafle, who is originally from Nepal, was able to measure the mass of the dark matter in the Milky Way by studying the speed of stars throughout the galaxy, including the edges, which had never been studied to this detail before.

He used a robust technique developed by British astronomer James Jeans in 1915 -- decades before the discovery of dark matter.

Dr Kafle's measurement helps to solve a mystery that has been haunting theorists for almost two decades.

"The current idea of galaxy formation and evolution, called the Lambda Cold Dark Matter theory, predicts that there should be a handful of big satellite galaxies around the Milky Way that are visible with the naked eye, but we don't see that," Dr Kafle said.

"When you use our measurement of the mass of the dark matter the theory predicts that there should only be three satellite galaxies out there, which is exactly what we see; the Large Magellanic Cloud, the Small Magellanic Cloud and the Sagittarius Dwarf Galaxy."

University of Sydney astrophysicist Professor Geraint Lewis, who was also involved in the research, said the missing satellite problem had been "a thorn in the cosmological side for almost 15 years."

"Dr Kafle's work has shown that it might not be as bad as everyone thought, although there are still problems to overcome," he said.

The study also presented a holistic model of the Milky Way, which allowed the scientists to measure several interesting things such as the speed required to leave the galaxy.

"Be prepared to hit 550 kilometres per second if you want to escape the gravitational clutches of our galaxy," Dr Kafle said.

"A rocket launched from Earth needs just 11 kilometres per second to leave its surface, which is already about 300 times faster than the maximum Australian speed limit in a car!"


Story Source:

The above story is based on materials provided by International Centre for Radio Astronomy Research (ICRAR). Note: Materials may be edited for content and length.


Journal Reference:

  1. Prajwal Raj Kafle, Sanjib Sharma, Geraint F. Lewis, Joss Bland-Hawthorn. On the Shoulders of Giants: Properties of the Stellar Halo and the Milky Way Mass Distribution. The Astrophysical Journal, 2014; 794 (1): 59 DOI: 10.1088/0004-637X/794/1/59

 

Mining big data yields Alzheimer's discovery

 

Scientists at The University of Manchester have used a new way of working to identify a new gene linked to neurodegenerative diseases such as Alzheimer's. The discovery fills in another piece of the jigsaw when it comes to identifying people most at risk of developing the condition.

Researcher David Ashbrook and colleagues from the UK and USA used two of the world's largest collections of scientific data to compare the genes in mice and humans. Using brain scans from the ENIGMA Consortium and genetic information from The Mouse Brain Library, he was able to identify a novel gene, MGST3 that regulates the size of the hippocampus in both mouse and human, which is linked to a group of neurodegenerative diseases. The study has just been published in the journal BMC Genomics.

David, who works in Dr Reinmar Hager's lab at the Faculty of Life Sciences, says: "There is already the 'reserve hypothesis' that a person with a bigger hippocampus will have more of it to lose before the symptoms of Alzheimer's are spotted. By using ENIGMA to look at hippocampus size in humans and the corresponding genes and then matching those with genes in mice from the BXD system held in the Mouse Brain Library database we could identify this specific gene that influences neurological diseases."

He continues: "Ultimately this could provide another biomarker in the toolkit for identifying those at greatest risk of developing diseases such as Alzheimer's."

Dr Hager, senior author of the study, says: "What is critical about this research is that we have not only been able to identify this specific gene but also the networks it uses to influence a disease like Alzheimer's. We believe this information will be incredibly useful for future studies looking at treatments and preventative measures."

The ENIGMA Consortium is led by Professor Paul Thompson based at the University of California, Los Angeles, and contains brain images and gene information from nearly 25,000 subjects. The Mouse Brain Library, established by Professor Robert Williams based at the University of Tennessee Health Science Center, contains data on over 10,000 brains and numerical data from just over 20,000 mice.

David explains why combining the information held by both databases is so useful: "The key advantage of working this way is that it is much easier to identify a genetic variant in mice as they live in such controlled environments. By taking the information from mice and comparing it to human gene information we can identify the same variant much more quickly."

And David thinks this way of working will be used more often in the future: "We are living in a big data world thanks to the likes of the Human Genome Project and post-genome technologies. A lot of that information is now widely shared so by mining what we already know we can learn so much more, advancing our knowledge of diseases and ultimately improving detection and treatment."


Story Source:

The above story is based on materials provided by Manchester University. Note: Materials may be edited for content and length.


Journal Reference:

  1. David G Ashbrook, Robert W Williams, Lu Lu, Jason L Stein, Derrek P Hibar, Thomas E Nichols, Sarah E Medland, Paul M Thompson, Reinmar Hager. Joint genetic analysis of hippocampal size in mouse and human identifies a novel gene linked to neurodegenerative disease. BMC Genomics, 2014; 15 (1): 850 DOI: 10.1186/1471-2164-15-850