Helping parents understand infant sleep patterns

 

December 19, 2014 Penn State Most parents are not surprised by the irregularity of a newborn infant's sleep patterns, but by six months or so many parents wonder if something is wrong with their baby or their sleeping arrangements if the baby is not sleeping through the night. Health-care providers, specifically nurse practitioners, can help parents understand what 'normal' sleep patterns are for their child, according to researchers. Most parents are not surprised by the irregularity of a newborn infant's sleep patterns, but by six months or so many parents wonder if something is wrong with their baby or their sleeping arrangements if the baby is not sleeping through the night. Healthcare providers, specifically nurse practitioners, can help parents understand what "normal" sleep patterns are for their child, according to researchers. "Nurse practitioners are at the frontline of healthcare," said Robin Yaure, senior instructor of human development and family studies, Penn State Mont Alto. "They are in an ideal position to help parents understand infant sleep pattern norms. Thus, nurse practitioners can help parents understand that 'sleeping through the night' is not entirely likely in young infants and that infants' sleep patterns change during the first few years of life." According to the researchers, there are four common areas of concern for both parents and practitioners: what constitutes "normal" infant sleep and waking patterns, whether nightwakings are a problem or not, is a parent's presence disruptive when an infant is falling asleep, and whether sleep training is safe and healthy for infants. Sleep training is one way to establish a sleep routine for a child, although the methods used may not be appealing to parents or in the best interests of the child, the researchers said. Yaure and colleagues reviewed current research on infant sleep, focusing on the above four areas of concern, and specifically infant safety and the well being of both infant and mother during nighttime care. The researchers suggest how to best integrate parents' preferences for care and best practice information, and include conversation points for nurse practitioners recently online in the Journal of the American Association of Nurse Practitioners. Infants' sleep patterns vary for at least the first three years of life. There are many reasons for this, including changes in infant health and mobility and the development of separation anxiety. "Sharing this basic information with parents is one way of assuring parents that infants' waking does not necessarily mean that the parents are doing something wrong," the researchers wrote. Parent presence at bedtime, sleep training and infant self-settling are frequently debated topics about which parents might look to healthcare professionals for advice. Yaure and colleagues again point to sharing information with parents -- for example, recent research suggests that the presence of parents at bedtime, specifically during the transition to sleep, may not trigger nightwakings as previously thought. The researchers also point out that recent research on the nonresponsiveness of mothers during nighttime care can raise stress for both mom and baby. Elevated stress increases cortisol in the body, which may hurt the baby in the long run. Increased cortisol levels are associated with depression, aggression and attention problems, among other issues, in children and adults. "I worry about parents who feel like they can't trust their own instincts," said Yaure. "Different parents have different goals and ideas for parenting, and we want parents to figure out how to incorporate best practices into their belief system. We have to be culturally aware and sensitive to different families and beliefs." By encouraging nurse practitioners to talk about current knowledge on infant nightwakings and parental presence, among other things, Yaure hopes that parents will become more comfortable and confident with their nighttime care choices. Further research will include how doctors can also help translate research-based knowledge of infant sleep into practice. Story Source: The above story is based on materials provided by Penn State. The original article was written by Victoria M. Indivero. Note: Materials may be edited for content and length. Journal Reference: Wendy Middlemiss, Robin Yaure, Erron L. Huey. Translating research-based knowledge about infant sleep into practice. Journal of the American Association of Nurse Practitioners, 2014; DOI: 10.1002/2327-6924.12159

No sedative necessary: Scientists discover new 'sleep node' in the brain

 

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Artist's concept (stock illustration). A sleep-promoting circuit located deep in the primitive brainstem has revealed how we fall into deep sleep.

A sleep-promoting circuit located deep in the primitive brainstem has revealed how we fall into deep sleep. Discovered by researchers at Harvard School of Medicine and the University at Buffalo School of Medicine and Biomedical Sciences, this is only the second "sleep node" identified in the mammalian brain whose activity appears to be both necessary and sufficient to produce deep sleep.

Published online in August in Nature Neuroscience, the study demonstrates that fully half of all of the brain's sleep-promoting activity originates from the parafacial zone (PZ) in the brainstem. The brainstem is a primordial part of the brain that regulates basic functions necessary for survival, such as breathing, blood pressure, heart rate and body temperature.

"The close association of a sleep center with other regions that are critical for life highlights the evolutionary importance of sleep in the brain," says Caroline E. Bass, assistant professor of Pharmacology and Toxicology in the UB School of Medicine and Biomedical Sciences and a co-author on the paper.

The researchers found that a specific type of neuron in the PZ that makes the neurotransmitter gamma-aminobutyric acid (GABA) is responsible for deep sleep. They used a set of innovative tools to precisely control these neurons remotely, in essence giving them the ability to turn the neurons on and off at will.

"These new molecular approaches allow unprecedented control over brain function at the cellular level," says Christelle Ancelet, postdoctoral fellow at Harvard School of Medicine. "Before these tools were developed, we often used 'electrical stimulation' to activate a region, but the problem is that doing so stimulates everything the electrode touches and even surrounding areas it didn't. It was a sledgehammer approach, when what we needed was a scalpel."

"To get the precision required for these experiments, we introduced a virus into the PZ that expressed a 'designer' receptor on GABA neurons only but didn't otherwise alter brain function," explains Patrick Fuller, assistant professor at Harvard and senior author on the paper. "When we turned on the GABA neurons in the PZ, the animals quickly fell into a deep sleep without the use of sedatives or sleep aids."

How these neurons interact in the brain with other sleep and wake-promoting brain regions still need to be studied, the researchers say, but eventually these findings may translate into new medications for treating sleep disorders, including insomnia, and the development of better and safer anesthetics.

"We are at a truly transformative point in neuroscience," says Bass, "where the use of designer genes gives us unprecedented ability to control the brain. We can now answer fundamental questions of brain function, which have traditionally been beyond our reach, including the 'why' of sleep, one of the more enduring mysteries in the neurosciences."

The work was funded by the National Institutes of Health.

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Story Source:

The above story is based on materials provided by University at Buffalo. The original article was written by Ellen Goldbaum. Note: Materials may be edited for content and length.

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Journal Reference:

1. Christelle Anaclet, Loris Ferrari, Elda Arrigoni, Caroline E Bass, Clifford B Saper, Jun Lu, Patrick M Fuller. The GABAergic parafacial zone is a medullary slow wave sleep–promoting center. Nature Neuroscience, 2014; 17 (9): 1217 DOI: 10.1038/nn.3789

Theories of Sleep

 

By Kendra Cherry (about.com)

Sleep has been the subject of speculation and thought since the time of the early Greek philosophers, but only recently have researchers discovered ways to study sleep in a systematic and objective way. The advent of new technology such as the electroencephalograph (EEG) has allowed scientists to look at and measure electrical patterns and activity produced by the sleeping brain.

While we can now investigate sleep and related phenomena, not all researchers agree on exactly why we sleep. A number of different theories have been proposed to explain the necessity of sleep as well as the functions and purposes of sleep.

The following are three of the major theories that have emerged:

Repair and Restoration Theory of Sleep:

According to the repair and restoration theory of sleep, sleeping is essential for revitalizing and restoring the physiological processes that keep the body and mind healthy and properly functioning. This theory suggests that NREM sleep is important for restoring physiological functions, while REM sleep is essential in restoring mental functions.

Support for this theory is provided by research that shows periods of REM sleep increase following periods of sleep deprivation and strenuous physical activity. During sleep, the body also increases its rate of cell division and protein synthesis, further suggesting that repair and restoration occurs during sleeping periods.

Recently, researchers have uncovered new evidence supporting the repair and restoration theory, discovering that sleep allows the brain to perform "housekeeping" duties.

In an October 2013 issue of the journal Science, researchers published the results of a study indicating that the brain utilizes sleep to flush out waste toxins. This waste removal system, they suggest, is one of the major reasons why we sleep."The restorative function of sleep may be a consequence of the enhanced removal of potentially neurotoxic waste products that accumulate in the awake central nervous system," the study's authors explain.

Earlier research had uncovered the glymphatic system, which carries waste materials out of the brain. According to one of the study's authors, Dr. Maiken Nedergaard, the brain's limited resources force it to choose between two different functional states: awake and alert or asleep and cleaning up. They also suggest that problems with cleaning out this brain waste might play a role in a number of brain disorders such as Alzheimer's disease.

Evolutionary Theory of Sleep:

Evolutionary theory, also known as the adaptive theory of sleep, suggests that periods of activity and inactivity evolved as a means of conserving energy. According to this theory, all species have adapted to sleep during periods of time when wakefulness would be the most hazardous.

Support for this theory comes from comparative research of different animal species. Animals that have few natural predators, such as bears and lions, often sleep between 12 to 15 hours each day. On the other hand, animals that have many natural predators have only short periods of sleep, usually getting no more than 4 or 5 hours of sleep each day.

Information Consolidation Theory of Sleep:

The information consolidation theory of sleep is based on cognitive research and suggests that people sleep in order to process information that has been acquired during the day. In addition to processing information from the day prior, this theory also argues that sleep allows the brain to prepare for the day to come.

Some research also suggests that sleep helps cement the things we have learned during the day into long-term memory. Support for this idea stems from a number of sleep deprivation studies demonstrating that a lack of sleep has a serious impact on the ability to recall and remember information.

Final Thoughts:

While there is research and evidence to support each of these theories of sleep, there is still no clear-cut support for any one theory. It is also possible that each of these theories can be used to explain why we sleep. Sleeping impacts many physiological processes, so it is very possible that sleep occurs for many reasons and purposes.

Does the moon affect our sleep? Research says no

 

June 17, 2014

No correlation between moon phases and human sleep has been found by researchers studying the topic. For centuries, people have believed that the moon cycle influences human health, behavior and physiology. Folklore mainly links the full moon with sleeplessness. "We could not observe a statistical relevant correlation between human sleep and the lunar phases," remarked researchers after a large study completed.

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Popular beliefs about the influence of the moon on humans widely exist. Many people report sleeplessness around the time of full moon. In contrast to earlier studies, scientists from the Max Planck Institute of Psychiatry in Munich did not observe any correlation between human sleep and the lunar phases. The researchers analyzed preexisting data of a large cohort of volunteers and their sleep nights. Further identification of mostly unpublished null findings suggests that the conflicting results of previous studies might be due to a publication bias.

For centuries, people have believed that the moon cycle influences human health, behavior and physiology. Folklore mainly links the full moon with sleeplessness. But what about the scientific background?

Several studies searched in re-analyses of pre-existing datasets on human sleep for a lunar effect, although the results were quite varying and the effects on sleep have rarely been assessed with objective measures, such as a sleep EEG. In some studies women appeared more affected by the moon phase, in others men. Two analyses of datasets from 2013 and 2014, each including between 30 and 50 volunteers, agreed on shorter total sleep duration in the nights around full moon. However, both studies came to conflicting results in other variables. For example, in one analysis the beginning of the REM-sleep phase in which we mainly dream was delayed around new moon, whereas the other study observed the longest delay around full moon.

To overcome the problem of possible chance findings in small study samples, scientists now analyzed the sleep data of overall 1,265 volunteers during 2,097 nights. "Investigating this large cohort of test persons and sleep nights, we were unable to replicate previous findings,"  " It has been  observed a statistical relevant correlation between human sleep and the lunar phases." Further, his team identified several unpublished null findings including cumulative analyses of more than 20,000 sleep nights, which suggest that the conflicting results might be an example of a publication bias (i.e. the file drawer problem).

The file drawer problem describes the phenomenon, that many studies may be conducted but never reported -- they remain in the file drawer. One much-discussed publication bias in science, medicine and pharmacy is the tendency to report experimental results that are positive or show a significant finding and to omit results that are negative or inconclusive.

Up to now, the influence of the lunar cycle on human sleep was investigated in re-analyses of earlier studies which originally followed different purposes. "To overcome the obvious limitations of retrospective data analysis, carefully controlled studies specifically designed for the test of lunar cycle effects on sleep in large samples are required for a definite answer”

Sleep calculator

 

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