Mostrando postagens com marcador Cardiovascular system. Mostrar todas as postagens
Mostrando postagens com marcador Cardiovascular system. Mostrar todas as postagens

quarta-feira, 29 de outubro de 2014

Governments should take active lead to create healthy food environments to prevent cardiovascular disease

 

In 2010, unhealthy eating was identified as the leading risk for death and disability both in Canada and globally. In Canada, as in most industrialized countries, preventable cardiovascular disease, diabetes, cancer, and chronic respiratory disease account for roughly two-thirds of all deaths each year. Poor diet, broadly defined by the World Health Organization (WHO) as one being high in sodium, saturated and trans fats, free sugar, and low in fresh fruits and vegetables, is among the leading risk factors.

Led by the Canadian Institutes of Health Research/Heart & Stroke Foundation of Canada (CIHR/HSF) Chair in Hypertension Prevention and Control , supported by fifteen leading national and provincial health organizations, this position statement calls upon governments to take action to develop and implement healthy food procurement policies across the spectrum of our society. It also outlines key roles and recommendations for the commercial and non-commercial sectors including health and scientific organizations as well as the Canadian public.

The statement is based on a systematic review of the literature that found healthy food procurement interventions do have an important impact on food purchases within closed systems such as schools, workplaces, and isolated communities. The review further acknowledged that successful food procurement policies are nearly always accompanied by supporting education programs and sometimes by pricing policies, such as taxation or subsidies.

This statement is part of an international movement to reduce dietary risk, with the recognition that toxic foods (with excessive amounts of sugar, fat, refined grain products, and/or salt) are responsible for substantial population sickness and premature death. The supporting organizations call on all individuals, but specifically those with organizational responsibility for others, to immediately begin to work on implementing healthy food procurement policies as part of a comprehensive approach to reduce dietary risk and prevent diet-related disease.

"Education, knowledge, and awareness are not enough. Extensive education over a period of years, even in clinical trial settings, has only a small sustained impact on sodium consumption and obesity reduction," says Norm Campbell, MD, FRCPC, Professor of Medicine, Physiology and Pharmacology and Community Health Sciences, at the Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada, and chair of the Canadian Hypertension Advisory Committee. "The solution advocated by the United Nations and WHO focuses on a series of integrated governmental policies to improve the food environment coupled with education. Studies in the US show that implementing healthy food procurement policies in the commercial sector as a part of a worksite wellness program has the potential to save businesses money through improved productivity and reduced absenteeism. Canada has the opportunity to do the same through widespread adoption of such policies. Canadians can't make healthy choices if they don't have an environment that supports them making such choices. This is one step in that direction."

Among the recommendations are:

  • In conjunction with healthy food procurement, implement an education program about healthy eating and describe the rationale for the food procurement policy to ensure support and to increase awareness, desire, and demand for healthy dietary choices.
  • Encourage consumption of fresh foods (fruits, vegetables, etc.) or if not available, frozen or canned (without addition of sodium, sugar, or fats).
  • Take steps to ensure healthier foods and beverages are affordable.
  • Ensure that foods are well suited to the tastes/preferences/dietary needs of the population being served (e.g., age, ethno-cultural groups).
  • Include criteria for the amount of sodium, free sugars, trans fatty acids, saturated fats, and calories as well as other nutrients likely to impact health (e.g., dietary fiber) in the food being served.
  • Use national standards such as the Canadian Dietary Reference Intake Values, developed by the Institute of Medicine, and Canada's Guide to Healthy Eating in developing criteria for foods.
  • Make gradual changes in the nutrient criteria where personal tastes require time to adapt to change (e.g., sodium).
  • Update the policy periodically to reflect current nutrient needs.
  • Evaluate the implementation program and, where appropriate, introduce effective incentives for compliance.

This call to action is supported by the Alberta Policy Coalition for Chronic Disease Prevention, Canadian Association of Cardiac Rehabilitation and Prevention, Canadian Association on Gerontology, Canadian Council of Cardiovascular Nurses, Canadian Diabetes Association, Canadian Geriatrics Society, Canadian Nurses Association, Canadian Society for Exercise Physiology, Canadian Society of Internal Medicine, Canadian Society of Nephrology, Canadian Stroke Network, Champlain Cardiovascular Disease Prevention Network, College of Family Physicians of Canada, Heart and Stroke Foundation, and Hypertension Canada.

In a timely viewpoint article, "Death by Diet: The Role of Food Pricing Interventions as a Public Policy Response and Health Advocacy Opportunity," published in the same issue, experts discuss the role of health professionals as health advocates and the corresponding opportunity to support other population level approaches, namely food taxes and subsidies, to improve diet for the prevention of diet-related chronic disease.

"Similar to efforts being proposed in other countries, Canada needs a comprehensive agenda for action to curb the rising tide of diet-related disease. While this paper highlights the need for more research in the area of diet and policy-level strategies, it also identifies the opportunity for the cardiovascular community to be involved in policy initiatives and partnerships to begin to translate what we know can work into action and implementation," say lead author Tara Duhaney, MHSc, Policy Director of the Canadian Hypertension Advisory Committee, Alberta, Canada, and Norm Campbell, MD, FRCPC. "We hope this will further discussion, support, and action by all vested stakeholders including health professionals, researchers, communities, and, importantly, by all levels of government."

quarta-feira, 21 de maio de 2014

Adults who lose weight at any age could enjoy improved cardiovascular health

 


Weight loss at any age in adulthood is worthwhile because it could yield long-term heart and vascular benefits, suggests new research published in The Lancet Diabetes & Endocrinology.

The findings are from a study examining the impact of lifelong patterns of weight change on cardiovascular risk factors in a group of British men and women followed since birth in March 1946. They showed that the longer the exposure to excess body fat (adiposity) in adulthood the greater the cardiovascular-related problems in later life, including increased thickness of the carotid artery walls, raised systolic blood pressure, and increased risk of diabetes.

For the first time, the findings also indicate that adults who drop a BMI category -- from obese to overweight, or from overweight to normal -- at any time during adult life, even if they regain weight, can reduce these cardiovascular manifestations.

The study used data from 1273 men and women from the UK Medical Research Council National Survey of Health and Development (NSHD). Participants were classified as normal weight, overweight, or obese in childhood and at 36, 43, 53, and 60-64 years of age. Cardiovascular phenotyping between the ages of 60 and 64 years with carotid intima media thickness (cIMT; a surrogate marker for cardiovascular events) was used to assess the effect of lifetime exposure to adiposity on cardiovascular risk factors.

According to lead author Professor John Deanfield from University College London (UCL) in the UK, "Our study is unique because it followed individuals for such a long time, more than 60 years, and allowed us to assess the effect of modest, real-life changes in adiposity. Our findings suggest that losing weight at any age can result in long-term cardiovascular health benefits, and support public health strategies and lifestyle modifications that help individuals who are overweight or obese to lose weight at all ages."

Commenting on the study, Elizabeth Cespedes and Frank Hu from the Harvard School of Public Health, Boston, USA, write, "Although it is encouraging that even transitory weight loss during adulthood has cardiovascular benefits, only 2% of participants in the present study had a sustained reduction in BMI category in adulthood, underscoring the importance of weight maintenance and prevention of weight gain as priorities for public health programming and policy. Improvements in diet and increases in physical activity are crucial levers of long-term weight maintenance and prevention of weight gain in middle-age and early adulthood. Overweight individuals might have even greater health benefit from lifestyle changes such as increased physical activity than do normal weight individuals. The results of this study affirm a continued emphasis on public health policies that enable lifestyle changes to achieve and, especially, to maintain a healthy BMI."

They add that, "Ideally, future research will address long-term patterns of intentional versus unintentional weight loss, the means to achieve weight loss, and the weight loss maintenance necessary to reduce cardiovascular endpoints."


Story Source:

The above story is based on materials provided by The Lancet. Note: Materials may be edited for content and length.


Journal Reference:

  1. Marietta Charakida, Tauseef Khan, William Johnson, Nick Finer, John Woodside, Peter H Whincup, Naveed Sattar, Diana Kuh, Rebecca Hardy, John Deanfield. Lifelong patterns of BMI and cardiovascular phenotype in individuals aged 60–64 years in the 1946 British birth cohort study: an epidemiological study. The Lancet Diabetes & Endocrinology, 2014; DOI: 10.1016/S2213-8587(14)70103-2

quinta-feira, 27 de fevereiro de 2014

Come manomettere il sistema immunitario per prevenire danni dopo un infarto

 

 

Microparticelle che bloccano la risposta immunitaria del corpo verso i tessuti danneggiati potrebbero aiutare a prevenire danni ulteriori.

di Mike Orcutt

L'utilizzo di minuscole particelle biodegradabili per interrompere la normale risposta immunitaria del corpo dopo un infarto potrebbe contribuire a salvare i pazienti da danni ai tessuti e da alcune complicazioni per la salute che possono manifestarsi a lungo termine.
I ricercatori hanno
dimostrato che iniettando alcune particelle nei topi, entro 24 ore da un infarto, non solo si riduce significativamente il danno ai tessuti, ma in questi topi la funzione cardiaca risulta più forte dopo 30 giorni. Gli ideatori della nuova tecnologia ora intendono procedere con la sperimentazione sull'uomo.
Molti dei danni riportati dai tessuti a seguito di un infarto sono il risultato di un'infiammazione, una risposta immunitaria del corpo a uno stimolo nocivo come, per esempio, un muscolo danneggiato. Nel caso di un infarto, però, queste cellule immunitarie fanno più male che bene, spiega
Daniel Getts, ideatore della nuova terapia e direttore scientifico del Cour Pharmaceutical Development.
L’armamentario del sistema è "abbastanza generico", spiega. I composti tossici che le cellule immunitarie secernono, possono essere utili nel difendere il corpo dalle infezioni ma allo stesso tempo possono causare dei danni. Questo fenomeno si verifica non solo dopo un infarto, ma anche in una serie di altre malattie come il virus del Nilo Occidentale, le malattie infiammatorie intestinali e la sclerosi multipla.
Le 500 particelle nanometriche devono essere caricate negativamente e possono essere costituite da vari materiali, compreso quello utilizzato per le suture biodegradabili. Stando a
questa nuova ricerca, una volta che le particelle sono nel sangue, la carica negativa attrae uno specifico recettore sulla superficie dei monociti infiammatori, le particelle si legano a quel recettore e deviano le cellule immunitarie lontano dal cuore, verso la milza dove muoiono.
Impedendo a queste cellule di raggiungere il cuore si permette al muscolo danneggiato di rigenerarsi "durante processi più controllati", spiega Getts. Se la terapia si trasferisse alle persone, continua, si potrebbero ridurre sostanzialmente gli inconvenienti a lungo termine per la salute che, per pazienti colpiti da infarto, comprendono respiro corto e una limitata capacità di tenersi in esercizio.
L'obiettivo è quello di iniziare la sperimentazione sull'uomo all'inizio del prossimo anno. La compagnia conta sul meccanismo relativamente semplice della terapia, e il fatto che il materiale di cui sono costituite le particelle è composto da acido poliglicolico già approvato dalla Food and Drug Administration, velocizzerà lo sviluppo del processo.
"C'è ancora molto lavoro da fare", in particolare risolvere ogni potenziale effetto collaterale che le particelle potrebbero produrre, sostiene
Matthias Nahrendorf, professore di biologia dei sistemi ad Harvard. Ad esempio, le particelle possono attivare il sistema immunitario in molti modi ancora sconosciuti, spiega. Inoltre, sarà importante determinare come gestire la terapia in modo da non compromettere la capacità che hanno queste cellule di guarire e difendere il corpo da infezioni e da altri invasori esterni, dice Nahrendorf.

 

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