terça-feira, 16 de setembro de 2014

It's time to criminalise serious scientific misconduct

 

Why should research misconduct be illegal?
After 30 years of observing how science deals with the problem, I have sadly come to the conclusion that it should be a crime, for three main reasons. First, in a lot of cases, people have been given substantial grants to do honest research, so it really is no different from financial fraud or theft. Second, we have a whole criminal justice system that is in the business of gathering and weighing evidence – which universities and other employers of researchers are not very good at. And finally, science itself has failed to deal adequately with research misconduct.

How can we recognise honest mistakes?
It's quite difficult. Clearly not every minor misconduct should be regarded as a crime. And as with all laws, it will take time to establish what merits prosecution and what can be dealt with by a reprimand. But we know peer review doesn't detect all misconduct. If research seems wrong or impossible, we start with the assumption that it's just an honest mistake and then look into it. You can sometimes detect fraud statistically, because if you invent data you tend to come up with a recurrent pattern. But in most cases, it is detected because somebody blows a whistle.

Are there cases in which you think researchers should have been prosecuted?
There are cases where someone demonstrated intent, not simply made a horrible mistake. For example, I was involved in the case of a researcher named Malcolm Pearce, who published two papers in the British Journal of Obstetrics and Gynaecology. One was a
case report of successfully re-implanting an ectopic pregnancy into a patient's womb and another was a randomised trial about treating recurrent miscarriage. It turned out the case study patient did not exist, and there was also no record that he had actually conducted this randomised trial. Those aren't honest errors. The facts speak for themselves.

Does scientific misconduct often cause real social harm?
To begin with, there is the loss of confidence in science. But another example of clear, obvious harm is the infamous MMR-vaccine paper by Andrew Wakefield that was published in The Lancet. It suggested that the vaccine was a cause of autism, and that idea absolutely took off, causing dramatic drops in childhood vaccinations. This in turn caused outbreaks of diseases such as measles. Eventually, when claims in the paper were proven to be false, The Lancet
retracted it.

These types of things often ruin researchers' careers. Is that punishment enough?
There are many examples in which researchers have simply carried on with their careers. I believe scientists should be held to a higher standard. Those who commit research misconduct cannot be trusted. It's too easy to be tempted into ignoring or destroying data that undermines your work. It may seem an inhuman way to be, but a true scientist is delighted when his or her favourite hypothesis is destroyed by good data.

The evolution of human intelligence

 

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The nature and origins of hominid intelligence is a much-studied and much-debated topic, of natural interest to humans as the most successful and intelligent hominid species.

There is no universally accepted definition of intelligence, one definition is "the ability to reason, plan, solve problems, think abstractly, comprehend ideas and language, and learn." The evolution of hominid intelligence can be traced over its course for the past 10 million years, and attributed to specific environmental challenges.

It is a misunderstanding of evolutionary theory, however, to see this as a necessary process, and an even greater misunderstanding to see it as one directed to a particular outcome.

There are primate species which have not evolved any greater degree of intelligence than they had 10 million years ago: this is because their particular environment has not demanded this particular adaptation of them.

Intelligence as an adaptation to the challenge of natural selection is no better or worse than any other adaptation, such as the speed of the cheetah or the venomous bite of the cobra.

It is, however, the only adaptation which has allowed a species to establish complete domination over the rest of the natural world.

Whether our species has yet acquired sufficient intelligence to manage this responsibility is a matter for debate.

Note: This article excerpts material from the Wikipedia article "The evolution of human intelligence", which is released under the GNU Free Documentation License.

jaguar___ballpoint_pen_by_vianaarts-d51wc8w

Snap 2014-09-12 at 18.10.27

Evolutionary tools improve prospects for sustainable development

 


The pink bollworm, a global pest of cotton, has evolved resistance to genetically modified cotton in India, but not in Arizona where farmers have planted refuges of conventional cotton to reduce selection for resistance.

Solving societal challenges in food security, emerging diseases and biodiversity loss will require evolutionary thinking in order to be effective in the long run. Inattention to this will only lead to greater challenges such as short-lived medicines and agricultural treatments, problems that may ultimately hinder sustainable development, argues a new study published online today in Science Express, led by University of California, Davis and the Center for Macroecology, Evolution and Climate at the University of Copenhagen.

For the first time, scientists have reviewed progress in addressing a broad set of challenges in agriculture, medicine and environmental management using evolutionary approaches, approaches that consider species' evolutionary histories and the likelihood of rapid evolutionary adaptation to human activities.

The study finds an urgent need for better implementation of these approaches, for example in managing the use of antibiotics and pesticides in order to reduce the escalating problem of resistance evolution. Furthermore, current efforts are found insufficient to reduce the accumulating costs from chronic disease and biodiversity loss, two challenges ultimately caused by exposure to food and environments to which people and threatened wildlife are poorly adapted.

The study also assessed the potential for less commonly implemented strategies including gene therapies to treat human disease, the breeding of "climate change proof" crop varieties, such as flood tolerant rice, and translocating exotic strains for ecological restoration and forestry that will be better adapted to near-future conditions.

"Applying evolutionary biology has tremendous potential, because it takes into account how unwanted pests or pathogens may adapt rapidly to our interventions and how highly valued species including humans on the other hand are often very slow to adapt to changing environments through evolution. Not considering such aspects may result in outcomes opposite of those desired, making the pests more resistant to our actions, humans more exposed to diseases and vulnerable species less able to cope with new conditions," says biologist Peter Søgaard Jørgensen, one of the lead-authors and PhD from the Center for Macroecology, Evolution and Climate at the University of Copenhagen.

"To succeed in avoiding such unwanted outcomes however, we need to learn from successes and progress in all fields using evolutionary biology as a tool. Currently there is no such coordination, says Scott P. Carroll, lead-author and biologist at the University of California Davis and Director of the Institute for Contemporary Evolution. He continues:

"A particular worry is that the unaddressed need for management of evolution that spans multiple sectors will lead to the spread of new infectious diseases and antimicrobial resistance genes between natural, human health and agricultural systems. It is clear that we need to strengthen evolutionary biology linkages across nature conservation, food production and human health and develop a shared strategy."

Many evolutionary solutions are already at hand

Whereas we might have to wait for new solutions from human gene therapy, genetic engineering of crops and development of new medicines to replace old ones, many innovative solutions based on applying evolutionary biology already exist.

For example, farmers in the United States and Australia have used planting of pest-friendly refuges to delay evolution of insect resistance to genetically engineered corn and cotton. These genetically modified crops kill certain pests, but without refuges the pests quickly adapt. Providing refuges of conventional plants has been especially effective for suppressing resistance in the pink bollworm, an invasive pest of cotton.

However, Peter Jørgensen also cautions: "In many cases, decision makers must pay more attention to assuring that long-term benefits of applying these solutions do not come at a short-term cost for some individuals, for example from yield loss due to localised effects of pests in a particular year. By encouraging cost sharing, local communities and governments play a crucial role in ensuring that everybody gains from the benefits of using evolutionary biology to realise the long-term goals of sustainable development such as increasing food security, protecting biodiversity and improving human health and well-being."

The article is published today in Science Express. Peter Jørgensen will also present the research at the upcoming Sustainability Science Congress in Copenhagen from October 22nd to 24th.

Snap 2014-09-12 at 18.10.27


Story Source:

The above story is based on materials provided by Faculty of Science - University of Copenhagen. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. P. Carroll, P. S. Jorgensen, M. T. Kinnison, C. T. Bergstrom, R. F. Denison, P. Gluckman, T. B. Smith, S. Y. Strauss, B. E. Tabashnik. Applying evolutionary biology to address global challenges. Science, 2014; DOI: 10.1126/science.1245993

Piglet health: A better understanding of the immune response to intestinal parasites

 

September 12, 2014

Veterinärmedizinische Universität Wien

Parasitologists are closer to understanding the disease process behind porcine neonatal coccidiosis. The disease affects piglets during the first days of their life and can cause heavy diarrhea in the animals. The parasite Cystoisospora suis damages the intestinal mucosa to such a degree that it threatens the growth and survival of the pigs. The researchers have now analyzed the immune response to the infection.


Piglets.

Parasitologists from the University of Veterinary Medicine of Vienna are closer to understanding the disease process behind porcine neonatal coccidiosis. The disease affects piglets during the first days of their life and can cause heavy diarrhea in the animals. The parasite Cystoisospora suis damages the intestinal mucosa to such a degree that it threatens the growth and survival of the pigs. The researchers have now analysed the immune response to the infection. The results were published in the journal Parasite Immunology.

Porcine neonatal coccidiosis is a serious parasitic infection of young piglets that severely damages the intestinal mucosa, leading to diarrhea and reduced nutritional intake. As the infection reduces animal growth, and because secondary infections can result in increased mortality, the disease is responsible for substantial economic losses at affected pig farms.

"The developing immune system of neonatal piglets is not yet mature enough to deal with the parasites. For this reason, an infection shortly after birth results in weakened intestinal tissue with appropriate consequences. By comparison, Cystoisospora suisis absolutely harmless for adult pigs and their mature immune systems," explains first author Simone Gabner.

Immune cells grow more quickly in the intestines of infected piglets than in healthy ones

Scientists from the Institute of Parasitology at the Vetmeduni Vienna investigated how the developing immune system of piglets responds to an infection with Cystoisospora suis. For the purpose of the study, 25 animals aged three days were infected and observed in comparison with another 26 healthy, non-infected animals. The researchers analysed various different immune cells in the intestines of both groups over the course of the first days of life. High levels of so-called gamma delta T cells, a type of cell that recognizes tissue damage and activates the immune system, were found in infected piglets as early as four days after infection. Cytotoxic T-cells were detected eleven days after an infection. These are responsible for the cell death of infected cells and appear to have an immunologic memory function with regard to porcine neonatal coccidiosis.

Both types of T cells were detected significantly earlier in infected piglets than in non-infected animals. In healthy piglets, the T cells begin to settle in the intestine from about the third week of life.

"Before this, we didn't know which T cells played a part in porcine neonatal coccidiosis. Now we also know at which point they appear in the course and development of the disease. Their exact role in the intestines of the animals, however, remains unclear," Gabner says. "Cystoisospora suis affects epithelial cells in the intestine and destroys the natural barrier against pathogens. This makes secondary infections likely. We still don't know whether the T cells reduce the overall damage to the intestinal mucosa or if they perhaps cause the damage to the intestinal cells."

Innate immune system activated

Gabner and her colleagues also researched various receptors of the innate immune system in the piglets as well as signalling substances which play a part in the inflammatory response. Just four days after infection, the researchers found increased expression of certain pathogen receptors (TLR-2 and NOD2) and signalling molecules involved in inflammatory reactions (TNF-α) in the intestine of the infected animals. The parasite thus triggers the activation of the immune system. "Our research shows which signalling pathways could be involved. The immune response possibly begins even earlier. This is something to be investigated in future studies. We are one step closer to better understanding the disease," says Gabner.

Mother's milk a source of protection

Previous studies by the research group showed that protective antibodies against porcine neonatal coccidiosis are transferred to the piglets through the sow's milk directly after birth. Sows that had been exposed to the pathogen produced the respective antibodies from which the piglets could then benefit. In a follow-up study, the researchers went one step further. They deliberately infected sows with the parasites during gestation in order to increase the antibody levels in the maternal animals. The aim was to supply the piglets with as many antibodies from the mother's milk during their first days of life as possible. This "milk vaccination" was a success. The piglets of infected sows exhibited a less severe development of the disease than piglets of non-infected sows. The more antibodies a sow transferred to its piglets, the weaker the symptoms exhibited by the piglets.


Story Source:

The above story is based on materials provided by Veterinärmedizinische Universität Wien. Note: Materials may be edited for content and length.


Journal Reference:

  1. Simone Gabner, Hanna Lucia Worliczek, Kirsti Witter, Florian R. L. Meyer, Wilhelm Gerner, Anja Joachim. Immune response to Cystoisospora suis in piglets: local and systemic changes in T-cell subsets and selected mRNA transcripts in the small intestine. Parasite Immunology, 2014; DOI: 10.1111/pim.12116

Boosting armor for nuclear-waste eating microbes

 


A microbe developed to clean up nuclear waste and patented by a Michigan State University researcher has just been improved.

In earlier research, Gemma Reguera, MSU microbiologist, identified that Geobacter bacteria's tiny conductive hair-like appendages, or pili, did the yeoman's share of remediation. By increasing the strength of the pili nanowires, she improved their ability to clean up uranium and other toxic wastes.

In new research, published in the current issue of Applied and Environmental Microbiology, Reguera has added an additional layer of armor to her enhanced microbes.

The microbes also use the pili to stick to each other and grow a film on just about any surface, similar to the bacterial film that forms on teeth. The Geobacter biofilm, encased by a network of nanowires and slime, gives the bacteria a shield and increases their ability to neutralize even more uranium. The improvement also allows the bacteria to survive longer even when exposed to higher concentrations of the radioactive material.

Geobacter immobilizing uranium can be described as nature's version of electroplating. The beefed-up microbes engulf the uranium and turn it into a mineral, preventing the toxic material from leaching into groundwater.

Reguera's team had previously linked the conductive pili to the ability of the microbe to mineralize the soluble uranium. As the biofilm concentrates many nanowires around the Geobacter cells, more uranium can be bound and mineralized. The pili are immersed in a matrix of slime, which surrounds the biofilm cells and boosts the Geobacter's pili armor, so the biofilm now can pull double duty by helping mineralize uranium.

The shield keeps the uranium from penetrating deep into the Geobacter biofilm. By keeping this process on the surface of the film, the bacteria are not exposed to uranium and, as a community, they are able to clean up more toxic waste.

"The results surpassed our most optimistic predictions," Reguera said. "Even thin biofilms immobilized uranium like sponges. They reduced it to a mineral, all while not suffering any damage to themselves, for prolonged periods of time."

Even when exposed to extremely high and toxic concentrations of uranium, levels that would destroy individual Geobacter cells, the biofilms didn't just survive, they thrived, she added.

Additional MSU researchers contributing to the study include Dena Cologgi, Allison Speers and Blair Bullard. Shelly Kelly with EXAFS Analysis, also contributed to the study.

Reguera's future research on this front will focus on deciphering how the biofilm matrix that encases the cells shields them so effectively and how to improve its properties further.

Snap 2014-09-12 at 18.10.27


Story Source:

The above story is based on materials provided by Michigan State University. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. L. Cologgi, A. M. Speers, B. A. Bullard, S. D. Kelly, G. Reguera. Enhanced uranium immobilization and reduction by Geobacter sulfurreducens biofilms. Applied and Environmental Microbiology, 2014; DOI: 10.1128/AEM.02289-14

Technological leap in treating PCB contamination in the environment: Three new bacteria could break down PCB

 

September 15, 2014

National University of Singapore

Scientists have developed a novel approach that could greatly enhance the effectiveness of destroying polychlorinated biphenyls (PCBs) in the environment. They discovered three powerful bacteria that can degrade PCBs. In addition, the researchers also developed an effective method of culturing these PCB dechlorinators in large quantities to enhance their degradation efficiency.


A team of researchers from the National University of Singapore (NUS) Faculty of Engineering have developed a novel approach that could greatly enhance the effectiveness of destroying polychlorinated biphenyls (PCBs) in the environment. They discovered three powerful bacteria from a genus called Dehalococcoides which can degrade PCBs. In addition, the researchers also developed an effective method of culturing these PCB dechlorinators in large quantities to enhance their degradation efficiency.

Working with A*STAR's Genome Institute of Singapore (GIS), the team was able to identify the functional genes responsible for breaking down PCBs. With these research findings, it is now possible to design and engineer methods which can rid our environment of harmful PCBs more effectively. Their findings were recently published in the journal, Proceedings of the National Academy of Sciences (PNAS).

PCB contamination and challenges posed to environment

PCBs are synthetic organic chemical compounds of chlorine and biphenyl. They have been widely used as coolant fluids in many electrical products. However, they are toxic and exposure to PCBs has been known to show symptoms almost immediately. Though PCBs are no longer used (they have been banned since the 1970s), they are virtually indestructible and can possibly remain in the environment forever. Hence they continue to contaminate rivers, lakes and harbours worldwide, posing a threat to human and ecosystem health.

There have only been seven known enzymes associated with Dehalococcoides found to have confirmed function on chlorinated compounds. The NUS-GIS research team is proud to add the three new bacteria to the list -- each with distinct specificities.

An in-situ microbial detoxification strategy, which involves applying microbes directly to break down (dechlorinate) PCBs on-site, would be very effective for PCB bioremediation. However, these microbes are extremely hard to culture, hence limiting efforts to characterise them for such applications.

Currently, the only treatment is capping or dredging and landfilling the PCBs. An example is the ongoing SuperFund project to dredge the upper Hudson River to remove PCBs which has already cost nearly US$1 billion. In this regard, the novel technique developed by the research team to culture PCB dechlorinators could pave the way for alternative, and possibly more effective, methods of degrading PCBs on-site.

Novel substrate for culturing PCB dechlorinators

Associate Professor He Jianzhong, who is from the NUS Department of Civil & Environmental Engineering, explained, "While the scientific community has found out that certain bacteria can dechlorinate PCBs and make them more susceptible to oxidation, it was not until three decades ago that some were identified. However, challenges still remain in growing these organisms in quantities that will make an impact. Their low biomass has also prevented us from studying closely the process, especially in identifying the enzymes responsible. Furthermore, as PCBs are extremely insoluble, they are unsuitable as substrates for culturing the helpful bacteria."

To overcome this problem, the NUS team came out with an alternative substrate called Terrachloroethene (PCE) which can be used to boost the cell numbers of PCB dechlorinators.

"This discovery is a quantum leap forward in our understanding of microbial PCB dechlorination and hence open up new possibilities of developing more effective ways of destroying PCBs in our environment," said Assoc Prof He.

Genomic technologies to the fore

Dr Niranjan Nagarajan, who leads the research at GIS, said, "Through synergy generated from traditional culture techniques combined with state of the art genomic technologies, we could successfully cultivate and characterise three PCB dechlorinating microbial strains. From these efforts, we were able to be the first to identify the functional genes responsible for breaking down PCBs. These genes could be very useful as biomarkers for monitoring PCB bioremediation."

Assoc Prof He added, "Finding useful bacteria can be tough. Our work shows how advanced genomic technologies can be combined with culturing to sift through bacteria in the environment and find the gems. This is a big step forward in the development of in-situ microbial detoxification technologies for PCB bioremediation."

These discoveries promise to move the bioremediation technology for PCBs into the realm of reality because for the first time, bioaugmentation is feasible. The impact of this outstanding research is tremendous, which makes in-situ bioremediation possible by saving significant amount of time and labor. Future research will be focused on application of genomic technologies for in-situ degradation of PCBs and other halogenated compounds.

Snap 2014-09-12 at 18.10.27


Story Source:

The above story is based on materials provided by National University of Singapore. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. Wang, K. R. Chng, A. Wilm, S. Zhao, K.-L. Yang, N. Nagarajan, J. He. Genomic characterization of three unique Dehalococcoides that respire on persistent polychlorinated biphenyls. Proceedings of the National Academy of Sciences, 2014; 111 (33): 12103 DOI: 10.1073/pnas.1404845111

Peugeot highlights its Hybrid Air technology in new demonstrator car

 

Peugeot's Hybrid 208 2L demonstrator car complements a gasoline-air powertrain with weight...

Peugeot's Hybrid 208 2L demonstrator car complements a gasoline-air powertrain with weight- and drag-cutting measures

Image Gallery (5 images)

A car that runs on air? Peugeot is working on it. The French automaker revealed its Hybrid Air technology last year and will showcase the 208 Hybrid 2L Demonstrator car at the Paris Motor Show next month. The latest iteration of the Hybrid Air design complements the gasoline-air powertrain with weight- and drag-cutting measures to offer fuel economy in the range of 117 mpg (2 L/100km), which is well above the 81 mpg (2.9 L/100km) it was quoting last year.

Beginning with the 82-hp (61 kW) 1.2-liter PureTech 208 five-seater, Peugeot's engineers reached into their materials catalog, swapping in carbon composite body panels and coil springs. They also reworked the thickness of the stainless steel on the exhaust system to provide a 20 percent weight saving, helping slice 220 lb (100 kg) compared to the production 208, down to 1,896 lb (860 kg).

While exotic materials are sometimes dropped when a car moves from prototype to production, Peugeot says that its team looked specifically for "materials compatible with existing production facilities and a high manufacturing output," suggesting a production version could feature the same construction.

The Hybrid Air powertrain combines the 1.2-liter gasoline engine with a compressed-air drive. Unlike last year's Hybrid Air concept, which used a longitudinally mounted air tank running down the center of the car, the 208 Hybrid 2L carries its compressed air tank below the trunk, with a low-pressure expansion tank mounted near the rear axle. The compressed air works in conjunction with a front-mounted hydraulic motor/pump system to power the car and refill in about 10 seconds during deceleration or by way of compressed air developed by the three-cylinder engine.

Peugeot will show the 2L Hybrid Air 208 at the 2014 Paris Motor Show

A bespoke epicyclic transmission balances output from the two power sources. The car has a zero emissions Air mode for lower-speed urban driving, Petrol mode for steady highway driving, and Combined mode for "transition phases in urban environments, such as standing starts and acceleration." As the demonstrator model name indicates, this balance results in efficiency levels as high as 2L/100 km (117 mpg), an improvement from last year's 2.9L/100km (81 mpg) figure.

Gizmag will be attending the Paris Motor Show, and we'll look to get more information about this promising hybrid technology, including whether it is still on pace to launch within the next two years.

Source: Peugeot

Share About the Author

Upon graduating college with a poli sci degree, Chris toiled in the political world for several years. Realizing he was better off making cynical comments from afar than actually getting involved in all that mess, he turned away from matters of government and news to cover the things that really matter: outdoor recreation, cool cars, technology, wild gadgets and all forms of other toys. He's happily following the wisdom of his father who told him that if you find something you love to do, it won't really be work.   All articles by C.C. Weiss

Anyone who belittles efforts to improve fuel economy would do well to watch: www.youtube.com/watch?v=9jaQmcYEiME. It is 38 minutes long, but the first five minutes or so should be enough to get you hooked if you are a car driver or involved in road transport of any kind. It is also of interest to anyone who has swallowed the fracking hype and is in need of a dose of reality.

You might consider 'Googling' the presenter, Chris Martenson, to lend validity to what is said. One thing we can be sure of is that high performance cars and their excessive fuel consumption are in the winter of their lives. Not because fuel will be too expensive for those who can afford to buy such cars, but because driving one will be seen as anti-social and image is all important to such people.

Good luck to Peugeot - 117 mpg will be quite an achievement if it carries over into production, which appears to be their aim.

Mel Tisdale
16th September, 2014 @ 01:51 am PDT

Okay, this is just an air-gasoline hybrid, with the air being little more than a short distance buffer storage. We can't actually say it runs on air, then.

I have in fact seen compressed air driven cars more than a decade ago, running in the streets, only it was a neighborhood vehicle niche market then.

Running efficiency might not be the key feature of air cars. On the pro side, they do not require much precious resources and no dangerous materials, neither to make nor to run them.

Production and storage of pressurized air is easily possible without precious metals, and it can be losslessly stored forever, as opposed to electricity. Filling up is fast.

It may mot be the perfect solution as it is now, still I would not put it aside as silly. Roaling coal is silly. Technology evolves.

martinkopplow
16th September, 2014 @ 01:51 am PDT

segunda-feira, 15 de setembro de 2014

Google Launches Effort to Build Its Own Quantum Computer

 

Google’s crack at a quantum computer is a bid to change computing forever.

Why It Matters

Practical quantum computers could solve problems that would take conventional machines millions of years.

qubit wafer

Quantum core: Techniques developed at the University of California, Santa Barbara, to build this device, known as a qubit, will be used to try to build a working quantum computer at Google.

Google is about to begin designing and building hardware for a quantum computer, a type of machine that can exploit quantum physics to solve problems that would take a conventional computer millions of years.

Since 2009, Google has been working with controversial startup D-Wave Systems, which claims to make “the first commercial quantum computer.” And last year Google purchased one of D-Wave’s machines. But independent tests published earlier this year found no evidence that D-Wave’s computer uses quantum physics to solve problems more efficiently than a conventional machine.

Now John Martinis, a professor at University of California, Santa Barbara, has joined Google to establish a new quantum hardware lab near the university. He will try to make his own versions of the kind of chip inside a D-Wave machine.

Martinis has spent more than a decade working on a more proven approach to quantum computing, and built some of the largest, most error-free systems of qubits, the basic building blocks that encode information in a quantum computer.

“We would like to rethink the design and make the qubits in a different way,” says Martinis of his effort to improve on D-Wave’s hardware. “We think there’s an opportunity in the way we build our qubits to improve the machine.” Martinis has taken a joint position with Google and UCSB that will allow him to continue his own research at the university.

Quantum computers could be immensely faster than any existing computer at certain problems. That’s because qubits working together can use the quirks of quantum mechanics to quickly discard incorrect paths to a solution and home in on the correct one. However, qubits are tricky to operate because quantum states are so delicate.

Chris Monroe, a professor who leads a quantum computing lab at the University of Maryland, welcomed the news that one of the leading lights in the field was going to work on the question of whether designs like D-Wave’s can be useful. “I think this is a great development to have legitimate researchers give it a try,” he says.

Since showing off its first machine in 2007, D-Wave has irritated academic researchers by making claims for its computers without providing the evidence its critics say is needed to back them up. However, the company has attracted over $140 million in funding and sold several of its machines (see “The CIA and Jeff Bezos Bet on Quantum Computing”).

There is no question that D-Wave’s machine can perform calculations. And research published in 2011 showed that the machine’s chip harbors the right kind of quantum physics needed for quantum computing. But evidence is lacking that it uses that physics in the way needed to unlock the huge speedups promised by a quantum computer. It could be solving problems using only ordinary physics.

Martinis’s previous work has been focused on the conventional approach to quantum computing. He set a new milestone in the field this April, when his lab announced that it could operate five qubits together with relatively low error rates. Larger systems of such qubits could be configured to run just about any kind of algorithm depending on the problem at hand, much like a conventional computer. To be useful, a quantum computer would probably need to be built with tens of thousands of qubits or more.

The chip at the heart of D-Wave’s latest machine has 512 qubits, but they are wired into a different, more limited, component known as a quantum annealer. It can only run a specific algorithm used for a specific kind of problem that requires selecting the best option in a situation with many competing requirements—for example, determining the most efficient delivery route around a city.

Martinis was a coauthor on a paper published in Science earlier this year that took the most rigorous independent look at a D-Wave machine yet. It concluded that in the tests run on the computer, there was “no evidence of quantum speedup.” Without that, critics say, D-Wave is nothing more than an overhyped, and rather weird, conventional computer. The company counters that the tests of its machine involved the wrong kind of problems to demonstrate its benefits.

Martinis’s work on D-Wave’s machine led him into talks with Google, and to his new position. Theory and simulation suggest that it might be possible for annealers to deliver quantum speedups, and he considers it an open question. “There’s some really interesting science that people are trying to figure out,” he says.

Martinis thinks his technology for fabricating qubits could make better quantum annealers. Specifically, he hopes to make one whose qubits can more stably maintain a quantum state known as a superposition—effectively both 0 and 1 at the same time. The qubits of D-Wave’s machine can maintain superpositions for periods lasting only nanoseconds. Martinis has built qubits that can do that for as long as 30 microseconds, he says.

Martinis makes his qubits from aluminum circuits built on sapphire wafers and chills them to 20 millikelvin—a fraction above absolute zero—so that they become superconducting. D-Wave’s chip requires similar cooling to operate, but has circuits made from a superconducting material called niobium, on top of silicon wafers. Martinis is in the process of switching to making his own qubits on silicon, and believes certain electrical insulator materials used in D-Wave’s chips may be limiting its performance.

However, Google has not given up on D-Wave. In an online statement, the leader of Google’s quantum research said that the two companies will continue to work together, and that Google’s D-Wave computer will be upgraded with a new 1,000 qubit processor when it becomes available.

Snap 2014-09-11 at 20.03.19

Marijuana users who feel low get high

 

September 15, 2014

Journal of Studies on Alcohol and Drugs

Adolescents and young adults who smoke marijuana frequently may attempt to manage negative moods by using the drug, according to a study. "One of the challenges is that people often may use marijuana to feel better but may feel worse afterward," the lead investigator says. "Marijuana use can be associated with anxiety and other negative states. People feel bad, they use, and they might momentarily feel better, but then they feel worse. They don't necessarily link feeling bad after using with the use itself, so it can become a vicious circle."


Adolescents and young adults who smoke marijuana frequently may attempt to manage negative moods by using the drug, according to a study in September's Journal of Studies on Alcohol and Drugs.

"Young people who use marijuana frequently experience an increase in negative affect in the 24 hours leading up to a use event, which lends strong support to an affect-regulation model in this population," says the study's lead author Lydia A. Shrier, M.D., M.P.H., of the division of adolescent and young adult medicine at Boston Children's Hospital.

She notes that using marijuana as a coping technique for negative affect may make it harder for people to stop using the drug.

"One of the challenges is that people often may use marijuana to feel better but may feel worse afterward," she says. "Marijuana use can be associated with anxiety and other negative states. People feel bad, they use, and they might momentarily feel better, but then they feel worse. They don't necessarily link feeling bad after using with the use itself, so it can become a vicious circle."

For the study, Shrier and colleagues recruited 40 people, ages 15 to 24, who used marijuana at least twice a week, although their average was 9.7 times per week. They were trained to use a handheld computer that signaled them at a random time within three-hour intervals (four to six times per day) for two weeks. At each signal, participants were asked about their mood, companionship, perceived availability of marijuana, and recent marijuana use. Participants were also asked to report just before and just after any marijuana use. They completed more than 3,600 reports.

The researchers found that negative affect was significantly increased during the 24 hours before marijuana use compared with other periods. However, positive affect did not vary in the period before marijuana use compared with other times.

Also, neither the availability of marijuana nor the presence of friends modified the likelihood that chronic users would use marijuana following a period of negative affect.

The study is unique in that it collected data in real time to assess mood and marijuana use events. The study thus was able to identify mood that was occurring in the 24 hours before marijuana use and compared it with mood at other times, Shrier reports.

"There are a host of limitations with retrospective assessments, such as asking people 'the last time you used marijuana, why did you use it?'" according to Shrier. "We weren't asking people to predict anything or to recall anything -- we were just asking them to give us reports about how they were feeling right now. We were able to put under a microscope the association between those feelings and subsequent marijuana use."

Shrier says it could be beneficial for clinicians and counselors to help their patients identify patterns of negative affect and to implement alternative mood-regulation strategies to replace marijuana use.

Snap 2014-09-12 at 18.10.27


Story Source:

The above story is based on materials provided by Journal of Studies on Alcohol and Drugs. Note: Materials may be edited for content and length.


Journal Reference:

  1. Shrier, L. A., Ross, C. S., & Blood, E. A. Momentary positive and negative affect preceding marijuana use events in youth. Journal of Studies on Alcohol and Drugs, September 2014

New way to predict hurricane strength, destruction

 


A new study by Florida State University researchers demonstrates a different way of projecting a hurricane's strength and intensity that could give the public a better idea of a storm's potential for destruction.

Vasu Misra, associate professor of meteorology and co-director of the Florida Climate Institute, and fourth-year doctoral student Michael Kozar introduce in the Monthly Weather Review of the American Meteorological Society a new statistical model that complements hurricane forecasting by showing the size of storms, not just the wind speed.

The model predicts the amount of integrated kinetic energy within Atlantic tropical cyclones. This kinetic energy metric is related to the overall size and strength of a storm, not just the maximum wind speed. Predictions of this metric complement existing forecasting tools, potentially allowing forecasters to better assess the risk of hurricanes that make landfall.

"We don't perceive this to be an alternative to how storms are explained to the public, but a complement," Misra said.

Hurricane forecasts have traditionally focused on wind speeds as measured through the Saffir-Simpson Hurricane Wind Scale. For example, a storm that has wind speeds of 74 to 95 miles per hour would be called a Category 1 storm. A hurricane with wind speeds of 157 miles per hour or higher would be listed as a Category 5.

However, some of the most destructive hurricanes to hit the United States have been labeled a Category 1 or Category 2 because of their slower wind speeds.

Hurricane Ike, for example, was a category two storm when it made landfall in 2008, meaning it had maximum sustained winds of 96 to 110 miles per hour. Despite the modest rating on the Saffir-Simpson Hurricane Wind Scale, Hurricane Ike caused widespread destruction because it was such a large storm.

"When the National Hurricane Center says Category 1, the attitude by the public is that it's fine and they can live through it," Misra said. "But, the damage by flooding is typically more widespread in larger storms."

Added Kozar: "It's the wind that gets all the attention, but it's the flooding that causes much of the damage."

Kozar and Misra's work thus far has focused on using data on storms dating back to 1990. The next step in their research is to focus on real-time weather prediction, so they can show the model in action.

The research is supported by funding from NOAA and the U.S. Department of Agriculture.

Snap 2014-09-12 at 18.10.27


Story Source:

The above story is based on materials provided by Florida State University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Michael E. Kozar and Vasubandhu Misra. Statistical Prediction of Integrated Kinetic Energy in North Atlantic Tropical Cyclones. Monthly Weather Review, 2014 (in press) DOI: 10.1175/MWR-D-14-00117.1